Search Results - "Rijal, Pramila"

Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2 by Huo, Jiandong, Le Bas, Audrey, Ruza, Reinis R., Duyvesteyn, Helen M. E., Mikolajek, Halina, Malinauskas, Tomas, Tan, Tiong Kit, Rijal, Pramila, Dumoux, Maud, Ward, Philip N., Ren, Jingshan, Zhou, Daming, Harrison, Peter J., Weckener, Miriam, Clare, Daniel K., Vogirala, Vinod K., Radecke, Julika, Moynié, Lucile, Zhao, Yuguang, Gilbert-Jaramillo, Javier, Knight, Michael L., Tree, Julia A., Buttigieg, Karen R., Coombes, Naomi, Elmore, Michael J., Carroll, Miles W., Carrique, Loic, Shah, Pranav N. M., James, William, Townsend, Alain R., Stuart, David I., Owens, Raymond J., Naismith, James H.

“…The SARS-CoV-2 virus is more transmissible than previous coronaviruses and causes a more serious illness than influenza. The SARS-CoV-2 receptor binding domain…”
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Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike by Huo, Jiandong, Zhao, Yuguang, Ren, Jingshan, Zhou, Daming, Duyvesteyn, Helen M.E., Ginn, Helen M., Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Shah, Pranav N.M., Tan, Tiong Kit, Rijal, Pramila, Coombes, Naomi, Bewley, Kevin R., Tree, Julia A., Radecke, Julika, Paterson, Neil G., Supasa, Piyada, Mongkolsapaya, Juthathip, Screaton, Gavin R., Carroll, Miles, Townsend, Alain, Fry, Elizabeth E., Owens, Raymond J., Stuart, David I.

“…There are as yet no licensed therapeutics for the COVID-19 pandemic. The causal coronavirus (SARS-CoV-2) binds host cells via a trimeric spike whose receptor…”
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Overcoming Symmetry Mismatch in Vaccine Nanoassembly through Spontaneous Amidation by Rahikainen, Rolle, Rijal, Pramila, Tan, Tiong Kit, Wu, Hung‐Jen, Andersson, Anne‐Marie C., Barrett, Jordan R., Bowden, Thomas A., Draper, Simon J., Townsend, Alain R., Howarth, Mark

“…Matching of symmetry at interfaces is a fundamental obstacle in molecular assembly. Virus‐like particles (VLPs) are important vaccine platforms against…”
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Recombinant single-cycle influenza virus with exchangeable pseudotypes allows repeated immunization to augment anti-tumour immunity with immune checkpoint inhibitors by Kandasamy, Matheswaran, Gileadi, Uzi, Rijal, Pramila, Tan, Tiong Kit, Lee, Lian N, Chen, Jili, Prota, Gennaro, Klenerman, Paul, Townsend, Alain, Cerundolo, Vincenzo

“…Virus-based tumour vaccines offer many advantages compared to other antigen-delivering systems. They generate concerted innate and adaptive immune response,…”
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Breadth and function of antibody response to acute SARS-CoV-2 infection in humans by Huang, Kuan-Ying A, Tan, Tiong Kit, Chen, Ting-Hua, Huang, Chung-Guei, Harvey, Ruth, Hussain, Saira, Chen, Cheng-Pin, Harding, Adam, Gilbert-Jaramillo, Javier, Liu, Xu, Knight, Michael, Schimanski, Lisa, Shih, Shin-Ru, Lin, Yi-Chun, Cheng, Chien-Yu, Cheng, Shu-Hsing, Huang, Yhu-Chering, Lin, Tzou-Yien, Jan, Jia-Tsrong, Ma, Che, James, William, Daniels, Rodney S, McCauley, John W, Rijal, Pramila, Townsend, Alain R

“…Serological and plasmablast responses and plasmablast-derived IgG monoclonal antibodies (MAbs) have been analysed in three COVID-19 patients with different…”
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Therapeutic Monoclonal Antibodies for Ebola Virus Infection Derived from Vaccinated Humans by Rijal, Pramila, Elias, Sean C., Machado, Samara Rosendo, Xiao, Julie, Schimanski, Lisa, O’Dowd, Victoria, Baker, Terry, Barry, Emily, Mendelsohn, Simon C., Cherry, Catherine J., Jin, Jing, Labbé, Geneviève M., Donnellan, Francesca R., Rampling, Tommy, Dowall, Stuart, Rayner, Emma, Findlay-Wilson, Stephen, Carroll, Miles, Guo, Jia, Xu, Xiao-Ning, Huang, Kuan-Ying A., Takada, Ayato, Burgess, Gillian, McMillan, David, Popplewell, Andy, Lightwood, Daniel J., Draper, Simon J., Townsend, Alain R.

“…We describe therapeutic monoclonal antibodies isolated from human volunteers vaccinated with recombinant adenovirus expressing Ebola virus glycoprotein (EBOV…”
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Structural basis for a conserved neutralization epitope on the receptor-binding domain of SARS-CoV-2 by Huang, Kuan-Ying A., Chen, Xiaorui, Mohapatra, Arpita, Nguyen, Hong Thuy Vy, Schimanski, Lisa, Tan, Tiong Kit, Rijal, Pramila, Vester, Susan K., Hills, Rory A., Howarth, Mark, Keeffe, Jennifer R., Cohen, Alexander A., Kakutani, Leesa M., Wu, Yi-Min, Shahed-Al-Mahmud, Md, Chou, Yu-Chi, Bjorkman, Pamela J., Townsend, Alain R., Ma, Che

“…Antibody-mediated immunity plays a crucial role in protection against SARS-CoV-2 infection. We isolated a panel of neutralizing anti-receptor-binding domain…”
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The presence of broadly neutralizing anti-SARS-CoV-2 RBD antibodies elicited by primary series and booster dose of COVID-19 vaccine by Chen, Xiaorui, Mohapatra, Arpita, Nguyen, Hong Thuy Vy, Schimanski, Lisa, Kit Tan, Tiong, Rijal, Pramila, Chen, Cheng-Pin, Cheng, Shu-Hsing, Lee, Wen-Hsin, Chou, Yu-Chi, Townsend, Alain R, Ma, Che, Huang, Kuan-Ying A

“…Antibody-mediated immunity plays a key role in protection against SARS-CoV-2. We characterized B-cell-derived anti-SARS-CoV-2 RBD antibody repertoires from…”
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Spatial, temporal and molecular dynamics of swine influenza virus-specific CD8 tissue resident memory T cells by Martini, Veronica, Edmans, Matthew, Gubbins, Simon, Jayaraman, Siddharth, Paudyal, Basudev, Morgan, Sophie, McNee, Adam, Morin, Théo, Rijal, Pramila, Gerner, Wilhelm, Sewell, Andrew K., Inoue, Ryo, Bailey, Mick, Connelley, Timothy, Charleston, Bryan, Townsend, Alain, Beverley, Peter, Tchilian, Elma

“…For the first time we have defined naïve, central memory, effector memory and differentiated effector porcine CD8 T cells and analyzed their distribution in…”
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Fc-Mediated Functions of Porcine IgG Subclasses by Paudyal, Basudev, Mwangi, William, Rijal, Pramila, Schwartz, John C, Noble, Alistair, Shaw, Andrew, Sealy, Joshua E, Bonnet-Di Placido, Marie, Graham, Simon P, Townsend, Alain, Hammond, John A, Tchilian, Elma

“…The pig is an important agricultural species and powerful biomedical model. We have established the pig, a large natural host animal for influenza with many…”
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A direct contact pig influenza challenge model for assessing protective efficacy of monoclonal antibodies by McNee, Adam, Vanover, Daryll, Rijal, Pramila, Paudyal, Basudev, Lean, Fabian Z X, MacLoughlin, Ronan, Núñez, Alejandro, Townsend, Alain, Santangelo, Philip J, Tchilian, Elma

“…Monoclonal antibodies (mAbs) can be used to complement immunization for the therapy of influenza virus infection. We have established the pig, a natural large…”
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Publisher Correction: Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells by Barnkob, Mike B., Michaels, Yale S., André, Violaine, Macklin, Philip S., Gileadi, Uzi, Valvo, Salvatore, Rei, Margarida, Kulicke, Corinna, Chen, Ji-Li, Jain, Vitul, Woodcock, Victoria K., Colin-York, Huw, Hadjinicolaou, Andreas V., Kong, Youxin, Mayya, Viveka, Mazet, Julie M., Mead, Gracie-Jennah, Bull, Joshua A., Rijal, Pramila, Pugh, Christopher W., Townsend, Alain R., Gérard, Audrey, Olsen, Lars R., Fritzsche, Marco, Fulga, Tudor A., Dustin, Michael L., Jones, E. Yvonne, Cerundolo, Vincenzo

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Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells by Barnkob, Mike B., Michaels, Yale S., André, Violaine, Macklin, Philip S., Gileadi, Uzi, Valvo, Salvatore, Rei, Margarida, Kulicke, Corinna, Chen, Ji-Li, Jain, Vitul, Woodcock, Victoria K., Colin-York, Huw, Hadjinicolaou, Andreas V., Kong, Youxin, Mayya, Viveka, Mazet, Julie M., Mead, Gracie-Jennah, Bull, Joshua A., Rijal, Pramila, Pugh, Christopher W., Townsend, Alain R., Gérard, Audrey, Olsen, Lars R., Fritzsche, Marco, Fulga, Tudor A., Dustin, Michael L., Jones, E. Yvonne, Cerundolo, Vincenzo

“…Semaphorin-3A (SEMA3A) functions as a chemorepulsive signal during development and can affect T cells by altering their filamentous actin (F-actin)…”
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Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans by Holzer, Barbara, Rijal, Pramila, McNee, Adam, Paudyal, Basudev, Martini, Veronica, Clark, Becky, Manjegowda, Tanuja, Salguero, Francisco J, Bessell, Emily, Schwartz, John C, Moffat, Katy, Pedrera, Miriam, Graham, Simon P, Noble, Alistair, Bonnet-Di Placido, Marie, La Ragione, Roberto M, Mwangi, William, Beverley, Peter, McCauley, John W, Daniels, Rodney S, Hammond, John A, Townsend, Alain R, Tchilian, Elma

“…Pigs are natural hosts for the same subtypes of influenza A viruses as humans and integrally involved in virus evolution with frequent interspecies…”
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Structure-Based Modification of an Anti-neuraminidase Human Antibody Restores Protection Efficacy against the Drifted Influenza Virus by Jiang, Haihai, Peng, Weiyu, Qi, Jianxun, Chai, Yan, Song, Hao, Bi, Yuhai, Rijal, Pramila, Wang, Haiyuan, Oladejo, Babayemi O., Liu, Jinhua, Shi, Yi, Gao, George F., Townsend, Alain R., Wu, Yan

“…The immune system produces antibodies to protect the human body from harmful invaders. The monoclonal antibody (MAb) is one kind of effective antivirals. In…”
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Computational mining of B cell receptor repertoires reveals antigen-specific and convergent responses to Ebola vaccination by Richardson, Eve, Bibi, Sagida, McLean, Florence, Schimanski, Lisa, Rijal, Pramila, Ghraichy, Marie, von Niederhäusern, Valentin, Trück, Johannes, Clutterbuck, Elizabeth A, O'Connor, Daniel, Luhn, Kerstin, Townsend, Alain, Peters, Bjoern, Pollard, Andrew J, Deane, Charlotte M, Kelly, Dominic F

“…Outbreaks of Ebolaviruses, such as Sudanvirus (SUDV) in Uganda in 2022, demonstrate that species other than the Zaire ebolavirus (EBOV), which is currently the…”
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Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike by Huo, Jiandong, Zhao, Yuguang, Ren, Jingshan, Zhou, Daming, Duyvesteyn, Helen M.E., Ginn, Helen M., Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Shah, Pranav N.M., Tan, Tiong Kit, Rijal, Pramila, Coombes, Naomi, Bewley, Kevin R., Tree, Julia A., Radecke, Julika, Paterson, Neil G., Supasa, Piyada, Mongkolsapaya, Juthathip, Screaton, Gavin R., Carroll, Miles, Townsend, Alain, Fry, Elizabeth E., Owens, Raymond J., Stuart, David I.

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Immune responses following the first dose of the Sputnik V (Gam-COVID-Vac) by Jeewandara, Chandima, Fernando, Suranga, Pushpakumara, Pradeep Darshana, Ramu, Shyrar Tanussiya, Kamaladasa, Achala, Gunasekara, Banuri, Aberathna, Inoka Sepali, Kuruppu, Heshan, Ranasinghe, Thushali, Dayarathne, Shashika, Dissanayake, Osanda, Gamalath, Nayanathara, Ekanayake, Dinithi, Jayamali, Jewantha, Wijesinghe, Ayesha, Dissanayake, Madushika, Somathilake, Gayasha, Harvie, Michael, Danasekara, Saubhagya, Jayathilaka, Deshni, Wijayatilake, Helanka Dinesh Kumara, Weerasooriya, Nihal, Kekulandara, Chinthaka, Schimanski, Lisa, Rijal, Pramila, Tan, Tiong K., Dong, Tao, Townsend, Alain, Ogg, Graham S., Malavige, Gathsaurie Neelika

“…As the first dose of Gam-COVID-Vac, is currently used as a single dose vaccine in some countries, we investigated the immunogenicity of this at 4 weeks (327…”
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Low Dose Pig Anti-Influenza Virus Monoclonal Antibodies Reduce Lung Pathology but Do Not Prevent Virus Shedding by Paudyal, Basudev, McNee, Adam, Rijal, Pramila, Carr, B Veronica, Nunez, Alejandro, McCauley, John, Daniels, Rodney S, Townsend, Alain R, Hammond, John A, Tchilian, Elma

“…We have established the pig, a large natural host animal for influenza, with many physiological similarities to humans, as a robust model for testing the…”
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Correction: Breadth and function of antibody response to acute SARS-CoV-2 infection in humans by Huang, Kuan-Ying A, Tan, Tiong Kit, Chen, Ting-Hua, Huang, Chung-Guei, Harvey, Ruth, Hussain, Saira, Chen, Cheng-Pin, Harding, Adam, Gilbert-Jaramillo, Javier, Liu, Xu, Knight, Michael, Schimanski, Lisa, Shih, Shin-Ru, Lin, Yi-Chun, Cheng, Chien-Yu, Cheng, Shu-Hsing, Huang, Yhu-Chering, Lin, Tzou-Yien, Jan, Jia-Tsrong, Ma, Che, James, William, Daniels, Rodney S, McCauley, John W, Rijal, Pramila, Townsend, Alain R

“…[This corrects the article DOI: 10.1371/journal.ppat.1009352.]…”
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