Search Results - "Rihova, B."

Synthesis of Poly[N‑(2-hydroxypropyl)methacrylamide] Conjugates of Inhibitors of the ABC Transporter That Overcome Multidrug Resistance in Doxorubicin-Resistant P388 Cells in Vitro by Šubr, V, Sivák, L, Koziolová, E, Braunová, A, Pechar, M, Strohalm, J, Kabešová, M, Říhová, B, Ulbrich, K, Kovář, M

“…The effects of novel polymeric therapeutics based on water-soluble N-(2-hydroxypropyl)methacrylamide copolymers (P(HPMA)) bearing the anticancer drug…”
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New HPMA copolymer-based drug carriers with covalently bound hydrophobic substituents for solid tumour targeting by Chytil, P., Etrych, T., Koňák, Č., Šírová, M., Mrkvan, T., Bouček, J., Říhová, B., Ulbrich, K.

“…Various conjugates of anticancer drug doxorubicin (Dox) covalently bound by the hydrolytically degradable hydrazone bond to the drug carrier based on…”
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HPMA copolymers with pH-controlled release of doxorubicin: In vitro cytotoxicity and in vivo antitumor activity by Ulbrich, K, Etrych, T, Chytil, P, Jelı́nková, M, Řı́hová, B

“…Data on the synthesis, physicochemical characterisation and in vitro and in vivo biological properties of the new, nontargeted or antibody-targeted…”
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Polymer nitric oxide donors potentiate the treatment of experimental solid tumours by increasing drug accumulation in the tumour tissue by Studenovsky, M., Sivak, L., Sedlacek, O., Konefal, R., Horkova, V., Etrych, T., Kovar, M., Rihova, B., Sirova, M.

“…The delivery of nitric oxide (NO) specifically to solid tumours was explored in this study as a strategy to augment the passive accumulation of nanomedicines…”
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Polymeric drugs based on conjugates of synthetic and natural macromolecules: I. Synthesis and physico-chemical characterisation by Ulbrich, K, Šubr, V, Strohalm, J, Plocová, D, Jelı́nková, M, Řı́hová, B

“…This paper describes the synthesis, physico-chemical characteristics and results of selected biological tests of conjugates of antibodies or proteins with…”
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HPMA copolymer-bound doxorubicin induces immunogenic tumor cell death by Sirova, M, Kabesova, M, Kovar, L, Etrych, T, Strohalm, J, Ulbrich, K, Rihova, B

“…Treatment of murine EL4 T cell lymphoma with N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer conjugates of doxorubicin (Dox) leads to complete tumor…”
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Immunocompatibility and biocompatibility of cell delivery systems by Rihova, Blanka

“…Immunoisolation therapy overcomes important disadvantages of implanting free cells. By mechanically blocking immune attacks, synthetic membranes around grafted…”
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Surface Modification of Polyimide Sheets for Regenerative Medicine Applications by Van Vlierberghe, S, Sirova, M, Rossmann, P, Thielecke, H, Boterberg, V, Rihova, B, Schacht, E, Dubruel, P

“…In the present work, two strategies were elaborated to surface-functionalize implantable polyimide sheets. In the first methodology, cross-linkable vinyl…”
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Clinical implications of N-(2-hydroxypropyl)methacrylamide copolymers by Ríhová, B, Kubácková, K

“…Different anticancer drugs, farmorubicin, doxorubicin, paclitaxel and cis-platin have been conjugated through a Gly-Phe-Leu-Gly tetrapeptide side chain to a…”
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Synergistic Action of Doxorubicin Bound to the Polymeric Carrier Based on N-(2-Hydroxypropyl)methacrylamide Copolymers through an Amide or Hydrazone Bond by Říhová, B, Etrych, T, Šírová, M, Kovář, L, Hovorka, O, Kovář, M, Benda, A, Ulbrich, K

“…The cytostatic effects of polymeric conjugates based on N-(2-hydroxypropyl)methacrylamide copolymers (PHPMA) and containing doxorubicin bound through amide and…”
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High Level of Tregs Is a Positive Prognostic Marker in Patients with HPV-Positive Oral and Oropharyngeal Squamous Cell Carcinomas by Rihova, B., Prochazka, B., Klozar, J., Tachezy, R., Lukesova, Eva, Eckschlager, T., Grega, M., Koslabova, E., Boucek, Jan, Rotnaglova, E., Salakova, M.

“…Background. Human papillomaviruses (HPVs) have been proved as one of the etiological factors of oropharyngeal squamous cell carcinoma (OPSCC). Patients with…”
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Antibody-targeted Polymer-doxorubicin Conjugates with pH-controlled Activation by Ulbrich, K., Etrych, T., Chytil, P., Jelínková, M., íhová, B.

“…The paper is dealing with the synthesis and properties of new non-targeted or antibody-targeted polymer drug conjugates, bearing doxorubicin (DOX) attached via…”
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New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties by Etrych, Tomáš, Jelı́nková, Markéta, Řı́hová, Blanka, Ulbrich, Karel

“…In this paper we describe the synthesis, physico-chemical characteristics and results of tests of biological activity of polymer drugs based on conjugates of…”
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Doxorubicin release is not a prerequisite for the in vitro cytotoxicity of HPMA-based pharmaceuticals: In vitro effect of extra drug-free GlyPheLeuGly sequences by Říhová, B., Strohalm, J., Hovorka, O., Šubr, V., Etrych, T., Chytil, P., Pola, R., Plocová, D., Bouček, J., Ulbrich, K.

“…A systematic study was designed to elucidate differences in cytostatic activity in vitro between HPMA-based doxorubicin conjugates synthesized using different…”
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Doxorubicin bound to a HPMA copolymer carrier through hydrazone bond is effective also in a cancer cell line with a limited content of lysosomes by R̆ı́hová, B., Etrych, T., Pechar, M., Jelı́nková, M., Štastný, M., Hovorka, O., Kovář, M., Ulbrich, K.

“…We have synthesized conjugates containing doxorubicin (DOX) bound to oligopeptide side chains (GlyGly or GlyPheLeuGly) of a water-soluble copolymer carrier…”
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HPMA copolymer-bound doxorubicin targeted to tumor-specific antigen of BCL1 mouse B cell leukemia by Kovář, M, Mrkvan, T, Strohalm, J, Etrych, T, Ulbrich, K, Štastný, M, Řı́hová, B

“…N-(2-Hydroxypropyl)methacrylamide (HPMA) copolymer carrier containing the anticancer drug doxorubicin and targeted with B1 monoclonal antibody (mAb) to BCL1…”
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Polymer conjugates of the highly potent cytostatic drug 2-pyrrolinodoxorubicin by Studenovsky, M., Ulbrich, K., Ibrahimova, M., Rihova, B.

“…This paper describes the synthesis and biological evaluation of a conjugate of the highly cytotoxic drug 2-pyrrolinodoxorubicin (p-DOX) with an…”
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Polymeric anticancer drugs with pH-controlled activation by Ulbrich, K, Etrych, T, Chytil, P, Pechar, M, Jelinkova, M, Rihova, B

“…The paper is dealing with the synthesis and properties of new, nontargeted or antibody-targeted pH-sensitive polymer–doxorubicin (DOX) conjugates designed as…”
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PCN60 The Cost Study of Treating mCRC With Bevacizumab Plus Chemotherapy in the Real Clinical Practice in the Czech Republic by Hradecka, I, Rihova, B, Horova, R, Demlova, R

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Immunomodulating activities of soluble synthetic polymer-bound drugs by Rihova, Blanka

“…The introduction of a synthetic material into the body always affects different body systems, including the defense system. Synthetic polymers are usually…”
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