Search Results - "Rihon, Jérôme"
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Structural insights into the morpholino nucleic acid/RNA duplex using the new XNA builder Ducque in a molecular modeling pipeline
Published in Nucleic acids research (12-04-2024)“…The field of synthetic nucleic acids with novel backbone structures [xenobiotic nucleic acids (XNAs)] has flourished due to the increased importance of XNA…”
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Synthesis, antiviral activity, and computational study of β-d-xylofuranosyl nucleoside phosphonates
Published in European journal of medicinal chemistry (05-07-2023)“…Molecular dynamics (MD) simulations provided insights into the favorable interactions between xylose nucleosides bearing a phosphonate moiety at their…”
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Efficient and Accurate Potential Energy Surfaces of Puckering in Sugar-Modified Nucleosides
Published in Journal of chemical theory and computation (08-06-2021)“…Puckering of the sugar unit in nucleosides and nucleotides is an important structural aspect that directly influences the helical structure of nucleic acids…”
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Characterization of an HNA aptamer suggests a non-canonical G-quadruplex motif
Published in Nucleic acids research (25-08-2023)“…Abstract Nucleic acids not only form the basis of heredity, but are increasingly a source of novel nano-structures, -devices and drugs. This has spurred the…”
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Cyclic Peptides as T‑Type Calcium Channel Blockers: Characterization and Molecular Mapping of the Binding Site
Published in ACS pharmacology & translational science (13-08-2021)“…T-type calcium (CaV3) channels play a crucial role in the generation and propagation of action potentials in excitable cells and are considered potential drug…”
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