Search Results - "Rigoreau, L"

Selective AKR1C3 inhibitors do not recapitulate the anti-leukaemic activities of the pan-AKR1C inhibitor medroxyprogesterone acetate by Khanim, F, Davies, N, Veliça, P, Hayden, R, Ride, J, Pararasa, C, Chong, M G, Gunther, U, Veerapen, N, Winn, P, Farmer, R, Trivier, E, Rigoreau, L, Drayson, M, Bunce, C

“…Background: We and others have identified the aldo-keto reductase AKR1C3 as a potential drug target in prostate cancer, breast cancer and leukaemia. As a…”
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429 Development of extracellular signal-regulated kinase 5 (ERK5) inhibitors for anti-cancer therapy by Myers, S, Martin, N, Bawn, R, Blackburn, T, Barrett, L, Reuillon, T, Golding, B, Griffin, R, Hammonds, T, Hardcastle, I, Leung, H, Newell, D, Rigoreau, L, Wong, A, Cano, C

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Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries by Leahy, Justin J.J., Golding, Bernard T., Griffin, Roger J., Hardcastle, Ian R., Richardson, Caroline, Rigoreau, Laurent, Smith, Graeme C.M.

“…A solution-phase multiple-parallel synthesis approach was employed for the preparation of 6-, 7- and 8-aryl-substituted chromenone libraries, which were…”
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Discovery of Potent Chromen-4-one Inhibitors of the DNA-Dependent Protein Kinase (DNA-PK) Using a Small-Molecule Library Approach by Hardcastle, Ian R, Cockcroft, Xiaoling, Curtin, Nicola J, El-Murr, Marine Desage, Leahy, Justin J. J, Stockley, Martin, Golding, Bernard T, Rigoreau, Laurent, Richardson, Caroline, Smith, Graeme C. M, Griffin, Roger J

“…Structure−activity relationships for inhibition of DNA-dependent protein kinase (DNA-PK) have been defined for substituted chromen-4-ones. For the…”
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Selective Benzopyranone and Pyrimido[2,1-a]isoquinolin-4-one Inhibitors of DNA-Dependent Protein Kinase:  Synthesis, Structure−Activity Studies, and Radiosensitization of a Human Tumor Cell Line in Vitro by Griffin, Roger J, Fontana, Gabriele, Golding, Bernard T, Guiard, Sophie, Hardcastle, Ian R, Leahy, Justin J. J, Martin, Niall, Richardson, Caroline, Rigoreau, Laurent, Stockley, Martin, Smith, Graeme C. M

“…A diverse range of chromen-2-one, chromen-4-one and pyrimidoisoquinolin-4-one derivatives was synthesized and evaluated for inhibitory activity against the DNA…”
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Synthesis, crystal structure determination, and biological properties of the DNA-dependent protein kinase (DNA-PK) inhibitor 3-cyano-6-hydrazonomethyl-5-(4-pyridyl)pyrid-[1 H]-2-one (OK-1035) by Stockley, Martin, Clegg, William, Fontana, Gabriele, Golding, Bernard T, Martin, Niall, Rigoreau, Laurent J.M, Smith, Graeme C.M, Griffin, Roger J

“…The first reported synthesis of the DNA-PK inhibitor 3-cyano-6-hydrazonomethyl-5-(4-pyridyl)pyrid-[1 H]-2-one (OK-1035) is described. The structure of OK-1035…”
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