Management of multidrug-resistant tuberculosis: main recommendations of the Brazilian guidelines

Over the years, various recommendations have been made in pursuit of controlling resistance to antituberculosis drugs, especially multidrug resistance, in Brazil. Given the importance of standardizing those recommendations, the aim of this study was to describe the main recommendations of the Brazil...

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Published in:Jornal brasileiro de pneumologia Vol. 46; no. 2; p. e20190290
Main Authors: Ballestero, Jaqueline Garcia de Almeida, Garcia, Juliana Masini, Bollela, Valdes Roberto, Ruffino-Netto, Antonio, Dalcolmo, Margareth Maria Pretti, Moncaio, Ana Carolina Scarpel, Miguel, Nicoly Sanches, Rigolin, Isabela Zaccaro, Palha, Pedro Fredemir
Format: Journal Article
Language:English
Portuguese
Published: Brazil Sociedade Brasileira de Pneumologia e Tisiologia 2020
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Summary:Over the years, various recommendations have been made in pursuit of controlling resistance to antituberculosis drugs, especially multidrug resistance, in Brazil. Given the importance of standardizing those recommendations, the aim of this study was to describe the main recommendations of the Brazilian guidelines, primarily those related to the treatment and follow-up of cases of tuberculosis. From August through October of 2018, a document search was conducted via the websites of the Brazilian National Ministry of Health, the Brazilian National Tuberculosis Control Program, the JBP, and the Official Gazette of the Federal Republic of Brazil. Data were collected systematically by using a protocol designed specifically for this study. Documents published between 2004 and 2018 were selected. It was possible to understand and trace the history of the measures for the control of multidrug-resistant tuberculosis in Brazil from 2004, when the first documents related to the disease were published, up to 2018, when the second edition of the Brazilian National Guidelines for the Control of Tuberculosis was published. The contents of the documents were analyzed and grouped by case definition, diagnostic criteria, treatment, use of directly observed treatment; mechanisms of social protection for patients; data tools; and organization of care. This analysis allowed us to understand the efforts towards standardizing some measures in Brazil, not only identifying advances in the alignment with international prerogatives (case definition, incorporation of diagnostic technology, and treatment regimens) but also underscoring the need for greater clarity regarding the mechanisms of social protection and the organization of the care provided via the Brazilian health care system.
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AUTHOR CONTRIBUTIONS: JGAB conceived the proposal, guided data collection, and assisted in the organization of results, discussion of findings, and writing of the manuscript. JMG contributed to the writing of the research proposal, data collection, organization of results, and writing of the manuscript. VRB, ARN, and MPD contributed to the improvement of the methodology, discussion of results, and writing and revision of the final version of the manuscript. ACSM contributed to the organization and discussion of results, as well as to the writing of the manuscript. IZR and NSM assisted in data collection, literature review, updating of reverences, and writing of the manuscript. PFP guided the proposal, obtained institutional funding, and contributed to data collection, organization of results, and discussion and revision of the final version of the manuscript.
ISSN:1806-3756
1806-3713
1806-3756
DOI:10.36416/1806-3756/e20190290