Search Results - "Rigobello, MP"

Glutaredoxin 2 deficiency in mitochondria leads to a hepatic metabolic phenotype in mice by Scalcon, Valeria, Folda, Alessandra, Tonolo, Federica, Bindoli, Alberto, Ferri, Nicola, Arrigoni, Giorgio, Coppo, Lucia, Rigobello, Maria Pia

Get full text

[YIA] Insights into the mitochondrial functions of glutaredoxin 2 in cellular and mouse models by Scalcon, Valeria, Folda, Alessandra, Tonolo, Federica, Bindoli, Alberto, Ferri, Nicola, Arrigoni, Giorgio, Coppo, Lucia, Rigobello, Maria Pia

Get full text

Cancer cell death induced by phosphine gold(I) compounds targeting thioredoxin reductase by Gandin, Valentina, Fernandes, Aristi Potamitou, Rigobello, Maria Pia, Dani, Barbara, Sorrentino, Francesca, Tisato, Francesco, Björnstedt, Mikael, Bindoli, Alberto, Sturaro, Alberto, Rella, Rocco, Marzano, Cristina

“…The thioredoxin system, composed of thioredoxin reductase (TrxR), thioredoxin (Trx), and NADPH (nicotinamide adenine dinucleotide phosphate), plays a central…”
Get full text

Mitochondrial depletion of glutaredoxin 2 induces metabolic dysfunction-associated fatty liver disease in mice by Scalcon, Valeria, Folda, Alessandra, Lupo, Maria Giovanna, Tonolo, Federica, Pei, Naixuan, Battisti, Ilaria, Ferri, Nicola, Arrigoni, Giorgio, Bindoli, Alberto, Holmgren, Arne, Coppo, Lucia, Rigobello, Maria Pia

“…Glutaredoxin 2 (Grx2) is a glutathione-dependent oxidoreductase that facilitates glutathionylation/de-glutathionylation of target proteins. The main variants…”
Get full text

Mice lacking Grx2 in mitochondria exhibit a metabolic phenotype by Scalcon, V, Coppo, L, Folda, A, Tonolo, F, Bindoli, A, Ferri, N, Rigobello, MP

Get full text

Mitochondrial thioredoxin reductase inhibition by gold(I) compounds and concurrent stimulation of permeability transition and release of cytochrome c by Rigobello, Maria Pia, Scutari, Guido, Folda, Alessandra, Bindoli, Alberto

“…The effects of auranofin, chloro(triethylphosphine)gold(I) (TEPAu), and aurothiomalate on mitochondrial respiration, pyridine nucleotide redox state, membrane…”
Get full text

Methylselenol formed by spontaneous methylation of selenide is a superior selenium substrate to the thioredoxin and glutaredoxin systems by Fernandes, Aristi P, Wallenberg, Marita, Gandin, Valentina, Misra, Sougat, Tisato, Francesco, Marzano, Cristina, Rigobello, Maria Pia, Kumar, Sushil, Björnstedt, Mikael

“…Naturally occurring selenium compounds like selenite and selenodiglutathione are metabolized to selenide in plants and animals. This highly reactive form of…”
Get full text

Treatment of human cancer cells with selenite or tellurite in combination with auranofin enhances cell death due to redox shift by Rigobello, Maria Pia, Gandin, Valentina, Folda, Alessandra, Rundlöf, Anna-Klara, Fernandes, Aristi P., Bindoli, Alberto, Marzano, Cristina, Björnstedt, Mikael

“…Selenium is an essential trace element incorporated as selenocysteine in 25 human selenoproteins. Among them are thioredoxin reductases (TrxR) and glutathione…”
Get full text

Liver mitochondria alterations in a mouse model depleted of Grx2 by Scalcon, V, Folda, A, Tonolo, F, Bindoli, A, Holmgren, A, Rigobello, MP, Coppo, L

Get full text

Induction of mitochondrial permeability transition by auranofin, a Gold(I)‐phosphine derivative by Rigobello, Maria Pia, Scutari, Guido, Boscolo, Rita, Bindoli, Alberto

“…Gold(I)‐thiolate drugs are compounds that specifically interact with thiol and/or selenol groups and are essentially utilized in the treatment of rheumatoid…”
Get full text

Gold complexes inhibit mitochondrial thioredoxin reductase: consequences on mitochondrial functions by Pia Rigobello, Maria, Messori, Luigi, Marcon, Giordana, Agostina Cinellu, Maria, Bragadin, Marcantonio, Folda, Alessandra, Scutari, Guido, Bindoli, Alberto

“…The effects of gold(I) complexes (auranofin, triethylphosphine gold and aurothiomalate), gold(III) complexes ([Au(2,2 ′-diethylendiamine)Cl]Cl 2,…”
Get full text

Effects of redox modulation by inhibition of thioredoxin reductase on radiosensitivity and gene expression by Selenius, Markus, Hedman, Mattias, Brodin, David, Gandin, Valentina, Rigobello, Maria Pia, Flygare, Jenny, Marzano, Christine, Bindoli, Alberto, Brodin, Ola, Björnstedt, Mikael, Fernandes, Aristi P.

“…The thioredoxin system is a promising target when aiming to overcome the problem of clinical radiation resistance. Altered cellular redox status and redox…”
Get full text

Interaction of selenite and tellurite with thiol-dependent redox enzymes: Kinetics and mitochondrial implications by Rigobello, Maria Pia, Folda, Alessandra, Citta, Anna, Scutari, Guido, Gandin, Valentina, Fernandes, Aristi Potamitou, Rundlöf, Anna-Klara, Marzano, Cristina, Björnstedt, Mikael, Bindoli, Alberto

“…The interactions of selenite and tellurite with cytosolic and mitochondrial thioredoxin reductases (TrxR1 and TrxR2) and glutathione reductases (GR) from yeast…”
Get full text

Effect of auranofin on the mitochondrial generation of hydrogen peroxide. Role of thioredoxin reductase by Rigobello, Maria Pia, Folda, Alessandra, Baldoin, Maria Cristina, Scutari, Guido, Bindoli, Alberto

“…The mitochondrial production of hydrogen peroxide, in the presence of different respiratory substrates (succinate, glutamate, malate and isocitrate), is…”
Get more information

The modulation of thiol redox state affects the production and metabolism of hydrogen peroxide by heart mitochondria by Rigobello, Maria Pia, Folda, Alessandra, Scutari, Guido, Bindoli, Alberto

“…In rat heart mitochondria, auranofin, arsenite, diamide, and BCNU increase H 2O 2 formation, further stimulated by antimycin. However, in submitochondrial…”
Get full text

The mitochondrial antioxidant defence system and its response to oxidative stress by Rabilloud, Thierry, Heller, Manfred, Rigobello, Maria-Pia, Bindoli, Alberto, Aebersold, Ruedi, Lunardi, Joël

“…The antioxidant systems of mitochondria are not well known. Using a proteomics‐based approach, we defined these mitochondrial antioxidant systems and analyzed…”
Get full text

Differential effect of calcium ions on the cytosolic and mitochondrial thioredoxin reductase by Rigobello, Maria Pia, Vianello, Fabio, Folda, Alessandra, Roman, Chiara, Scutari, Guido, Bindoli, Alberto

“…The effect of calcium ions has been studied on three different isoforms of thioredoxin reductase. The cytosolic (TrxR1), mitochondrial (TrxR2), and the…”
Get full text

Effect of Metal Complexes on Thioredoxin Reductase and the Regulation of Mitochondrial Permeability Conditions by BRAGADIN, M, SCUTARI, G, FOLDA, A, BINDOLI, A, RIGOBELLO, M P

“…: Gold(I) compounds such as auranofin, chloro(triethylphosphine) gold(I), and aurothiomalate act on mitochondrial functional parameters by determining an…”
Get full text

Thallium Induces Apoptosis in Jurkat Cells by BRAGADIN, MARCANTONIO, TONINELLO, ANTONIO, BINDOLI, ALBERTO, RIGOBELLO, MARIA PIA, CANTON, MARCELLA

“…: Thallium induces swelling in mitochondria and apoptosis in Jurkat cells. Both the swelling and the apoptosis are inhibited by means of cyclosporine A (CsA),…”
Get full text

Purification of Mitochondrial Thioredoxin Reductase and Its Involvement in the Redox Regulation of Membrane Permeability by Rigobello, Maria Pia, Callegaro, Maria Teresa, Barzon, Elena, Benetti, Monica, Bindoli, Alberto

“…The isolation to purity of a rat liver mitochondrial thioredoxin reductase is reported. The mitochondrial enzyme shows a chromatographic behavior different…”
Get full text