Search Results - "Rigo Bonnin, Raül"

Different top-down approaches to estimate measurement uncertainty of whole blood tacrolimus mass concentration values by Rigo-Bonnin, Raül, Blanco-Font, Aurora, Canalias, Francesca

“…Values of mass concentration of tacrolimus in whole blood are commonly used by the clinicians for monitoring the status of a transplant patient and for…”
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Comparative Efficacy of Continuous Ceftazidime Infusion vs. Intermittent Bolus against In Vitro Ceftazidime-Susceptible and -Resistant Pseudomonas aeruginosa Biofilm by El Haj, Cristina, Agustí, Eugènia, Benavent, Eva, Soldevila-Boixader, Laura, Rigo-Bonnin, Raül, Tubau, Fe, Torrejón, Benjamín, Esteban, Jaime, Murillo, Oscar

“…: As the anti-biofilm pharmacokinetic/pharmacodynamic (PK/PD) properties of antibiotics are not well-defined, we have evaluated the PK/PD indices for different…”
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Measurement of total and free docetaxel concentration in human plasma by ultra-performance liquid chromatography–tandem mass spectrometry by Rigo-Bonnin, Raül, Cobo-Sacristán, Sara, Gonzalo-Diego, Núria, Colom, Helena, Muñoz-Sánchez, Carmen, Urruticoechea, Ander, Falo, Catalina, Alía, Pedro

“…[Display omitted] •We developed UPLC–MS/MS methods to measure total and free docetaxel in plasma.•Methods involved liquid–liquid extraction followed by dryness…”
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Sustained Inhibition of Calcineurin Activity With a Melt‐Dose Once‐daily Tacrolimus Formulation in Renal Transplant Recipients by Fontova, Pere, Colom, Helena, Rigo‐Bonnin, Raül, Bestard, Oriol, Vidal‐Alabró, Anna, van Merendonk, Lisanne N., Cerezo, Gema, Polo, Carolina, Montero, Nuria, Melilli, Edoardo, Manonelles, Anna, Meneghini, Maria, Coloma, Ana, Cruzado, Josep M., Torras, Joan, Grinyó, Josep M., Lloberas, Nuria

“…Tacrolimus (Tac) is the cornerstone calcineurin inhibitor in transplantation. Extended‐release Meltdose formulation (Tac‐LCP) offers better bioavailability…”
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Evaluation of Humoral and Cellular Immune Responses to the SARS-CoV-2 Vaccine in Patients With Common Variable Immunodeficiency Phenotype and Patient Receiving B-Cell Depletion Therapy by Antolí, Arnau, Rocamora-Blanch, Gemma, Framil, Mario, Mas-Bosch, Virgínia, Navarro, Sergio, Bermudez, Carla, Martinez-Yelamos, Sergio, Dopico, Eva, Calatayud, Laura, Garcia-Muñoz, Nadia, Hernández-Benítez, Luis Humberto, Riera-Mestre, Antoni, Bas, Jordi, Masuet-Aumatell, Cristina, Rigo-Bonnin, Raúl, Morandeira, Francisco, Solanich, Xavier

“…SARS-CoV-2 vaccines' effectiveness is not yet clearly known in immunocompromised patients. This study aims to assess the humoral and cellular specific immune…”
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Multicenter analytical evaluation of the automated electrochemiluminescence immunoassay for cyclosporine by Vogeser, Michael, Shipkova, Maria, Rigo-Bonnin, Raül, Wallemacq, Pierre, Orth, Matthias, Widmann, Monika, Verstraete, Alain G

“…Cyclosporine A (CsA) is used as a posttransplantation immunosuppressant drug, and careful monitoring of CsA concentration in whole blood is essential. A new…”
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Influence of the Circadian Timing System on Tacrolimus Pharmacokinetics and Pharmacodynamics After Kidney Transplantation by Fontova, Pere, Colom, Helena, Rigo-Bonnin, Raül, van Merendonk, Lisanne N, Vidal-Alabró, Anna, Montero, Nuria, Melilli, Edoardo, Meneghini, Maria, Manonelles, Anna, Cruzado, Josep M, Torras, Juan, Grinyó, Josep Maria, Bestard, Oriol, Lloberas, Nuria

“…Tacrolimus is the backbone immunosuppressant after solid organ transplantation. Tacrolimus has a narrow therapeutic window with large intra- and inter-patient…”
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Determination of ertapenem in plasma and ascitic fluid by UHPLC-MS/MS in cirrhotic patients with spontaneous bacterial peritonitis by Rigo-Bonnin, Raúl, Amador, Alberto, Núñez-Gárate, María, Mas-Bosch, Virgínia, Padullés, Ariadna, Cobo-Sacristán, Sara, Castellote, José

“…Spontaneous bacterial peritonitis is a frequent severe complication in cirrhotic patients with ascites. Carbapenem antibiotics are currently the treatment of…”
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The Effect of Intracellular Tacrolimus Exposure on Calcineurin Inhibition in Immediate- and Extended-Release Tacrolimus Formulations by Fontova, Pere, van Merendonk, Lisanne N, Vidal-Alabró, Anna, Rigo-Bonnin, Raül, Cerezo, Gema, van Oevelen, Stefaan, Bestard, Oriol, Melilli, Edoardo, Montero, Nuria, Coloma, Ana, Manonelles, Anna, Torras, Joan, Cruzado, Josep M, Grinyó, Josep M, Colom, Helena, Lloberas, Nuria

“…Despite intensive monitoring of whole blood tacrolimus concentrations, acute rejection after kidney transplantation occurs during tacrolimus therapy…”
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Methylprednisolone Pulses Plus Tacrolimus in Addition to Standard of Care vs. Standard of Care Alone in Patients With Severe COVID-19. A Randomized Controlled Trial by Solanich, Xavier, Antolí, Arnau, Rocamora-Blanch, Gemma, Padullés, Núria, Fanlo-Maresma, Marta, Iriarte, Adriana, Mitjavila, Francesca, Capdevila, Olga, Riera-Mestre, Antoni, Bas, Jordi, Vicens-Zygmunt, Vanesa, Niubó, Jordi, Calvo, Nahum, Bolivar, Santiago, Rigo-Bonnin, Raúl, Mensa-Vilaró, Anna, Arregui, Laura, Tebe, Cristian, Videla, Sebastià, Hereu, Pilar, Corbella, Xavier

“…Introduction: Severe lung injury is triggered by both the SARS-CoV-2 infection and the subsequent host-immune response in some COVID-19 patients. Methods: We…”
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Measurement of ceftazidime concentration in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry. Application to critically ill patients and patients with osteoarticular infections by Rigo-Bonnin, Raül, Cobo-Sacristán, Sara, Padullés, Ariadna, Ribera, Alba, Arbiol-Roca, Ariadna, Murillo, Óscar, Sabater-Riera, Joan, Alía, Pedro

“…Ceftazidime is an antibiotic belonging to the third generation of the cephalosporin family. It is indicated in the treatment of serious, simple or mixed…”
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Predictive Factors of Piperacillin Exposure and the Impact on Target Attainment after Continuous Infusion Administration to Critically Ill Patients by Martínez-Casanova, Javier, Esteve-Pitarch, Erika, Colom-Codina, Helena, Gumucio-Sanguino, Víctor Daniel, Cobo-Sacristán, Sara, Shaw, Evelyn, Maisterra-Santos, Kristel, Sabater-Riera, Joan, Pérez-Fernandez, Xosé L, Rigo-Bonnin, Raül, Tubau-Quintano, Fe, Carratalà, Jordi, Padullés-Zamora, Ariadna

“…Critically ill patients undergo significant pathophysiological changes that affect antibiotic pharmacokinetics. Piperacillin/tazobactam administered by…”
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Estimation of the uncertainty of values assigned to calibration materials prepared in-house: An example for hydroxychloroquine calibrators in blood-hemolysate-based matrix by Rigo-Bonnin, Raúl, Canalias, Francesca

“…•A bottom-up approach was proposed to estimate the uncertainty of calibrators prepared in-house.•Hydroxychloroquine calibrators in blood-matrix were used to…”
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Measurement uncertainty estimation of free drug concentrations in clinical laboratories using equilibrium dialysis by Rigo-Bonnin, Raúl, Mas-Bosch, Virgínia, Canalias, Francesca

“…Developing procedures based on equilibrium dialysis (ED) that allow measuring the free drug concentration in plasma improves therapeutic drug monitoring (TDM)…”
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Clinical outcomes after combination treatment with ceftazidime/avibactam and aztreonam for NDM-1/OXA-48/CTX-M-15-producing Klebsiella pneumoniae infection by Shaw, Evelyn, Rombauts, Alexander, Tubau, Fe, Padullés, Ariadna, Càmara, Jordi, Lozano, Toni, Cobo-Sacristán, Sara, Sabe, Núria, Grau, Imma, Rigo-Bonnin, Raül, Dominguez, M Angeles, Carratalà, Jordi

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Traceability of immunosuppressant's mass concentration results obtained using different commercial calibrators by Rigo-Bonnin, Raül, Canalias, Francesca

“…Due to the high inter-variability in immunosuppressants pharmacokinetics, therapeutic drug monitoring of these drugs is essential in order to minimize the risk…”
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Calculation of reference intervals for the concentrations of α-tocopherol and retinol in serum using indirect data-mining procedures by Rigo-Bonnin, Raúl, Aliart-Fernández, Irene, Escalante-Vilanova, Anna, Brunet, Mercè, Parra-Robert, Marina, Morales-Ruiz, Manuel

“…•Reference intervals for vitamin A and E were established using different indirect approaches.•Indirect approaches to establish reference intervals were…”
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Pre-existing Autoantibodies Neutralizing High Concentrations of Type I Interferons in Almost 10% of COVID-19 Patients Admitted to Intensive Care in Barcelona by Solanich, Xavier, Rigo-Bonnin, Raúl, Gumucio, Victor-David, Bastard, Paul, Rosain, Jérémie, Philippot, Quentin, Perez-Fernandez, Xosé-Luis, Fuset-Cabanes, Maria-Paz, Gordillo-Benitez, Miguel-Ángel, Suarez-Cuartin, Guillermo, Boza-Hernandez, Enric, Riera-Mestre, Antoni, Parra-Martínez, Alba, Colobran, Roger, Antolí, Arnau, Navarro, Sergio, Rocamora-Blanch, Gemma, Framil, Mario, Calatayud, Laura, Corbella, Xavier, Casanova, Jean-Laurent, Morandeira, Francisco, Sabater-Riera, Joan

“…It is important to predict which patients infected by SARS-CoV-2 are at higher risk of life-threatening COVID-19. Several studies suggest that neutralizing…”
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Efficacy of meropenem extended infusion vs intermittent bolus monotherapy and in combination with colistin against Pseudomonas aeruginosa biofilm by Benavent, Eva, Ulldemolins, Marta, El Haj, Cristina, Rigo-Bonnin, Raúl, Yu, Heidi, Wang, Lynn, Wickremasinghe, Hasini, Ariza, Javier, Murillo, Oscar

“…•f%T>MIC was the pharmacokinete/pharmacodynamic index that best correlated with the anti-biofilm efficacy of meropenem.•PD indices were better optimized by…”
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Reference change values based on uncertainty models by Rigo-Bonnin, Raúl, Muñoz-Provencio, Diego, Canalias, Francesca

“…•Uncertainty models are proposed to estimate the reference change values.•Uncertainty sources considered were related to analytical and extra-analytical…”
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