Search Results - "Rigo, Mauricio M"

PepSim: T-cell cross-reactivity prediction via comparison of peptide sequence and peptide-HLA structure by Hall-Swan, Sarah, Slone, Jared, Rigo, Mauricio M, Antunes, Dinler A, Lizée, Gregory, Kavraki, Lydia E

“…Peptide-HLA class I (pHLA) complexes on the surface of tumor cells can be targeted by cytotoxic T-cells to eliminate tumors, and this is one of the bases for…”
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Improved structural method for T-cell cross-reactivity prediction by Mendes, Marcus F.A., Antunes, Dinler A., Rigo, Maurício M., Sinigaglia, Marialva, Vieira, Gustavo F.

“…•An improved cross reactivity prediction method.•We search all HLA:0201 crystal structures and mapping contact region between TCR/p:MHC.•We use potential…”
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APE-Gen2.0: Expanding Rapid Class I Peptide–Major Histocompatibility Complex Modeling to Post-Translational Modifications and Noncanonical Peptide Geometries by Fasoulis, Romanos, Rigo, Mauricio M., Lizée, Gregory, Antunes, Dinler A., Kavraki, Lydia E.

“…The recognition of peptides bound to class I major histocompatibility complex (MHC-I) receptors by T-cell receptors (TCRs) is a determinant of triggering the…”
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DINC-COVID: A webserver for ensemble docking with flexible SARS-CoV-2 proteins by Hall-Swan, Sarah, Devaurs, Didier, Rigo, Mauricio M., Antunes, Dinler A., Kavraki, Lydia E., Zanatta, Geancarlo

“…An unprecedented research effort has been undertaken in response to the ongoing COVID-19 pandemic. This has included the determination of hundreds of…”
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Structure-based Methods for Binding Mode and Binding Affinity Prediction for Peptide-MHC Complexes by Antunes, Dinler A, Abella, Jayvee R, Devaurs, Didier, Rigo, Maurício M, Kavraki, Lydia E

“…Understanding the mechanisms involved in the activation of an immune response is essential to many fields in human health, including vaccine development and…”
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Host expression system modulates recombinant Hsp70 activity through post‐translational modifications by Rigo, Mauricio M., Borges, Thiago J., Lang, Benjamin J., Murshid, Ayesha,  , Nitika, Wolfgeher, Donald, Calderwood, Stuart K., Truman, Andrew W., Bonorino, Cristina

“…The use of model organisms for recombinant protein production results in the addition of model‐specific post‐translational modifications (PTMs) that can affect…”
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Interpreting T-Cell Cross-reactivity through Structure: Implications for TCR-Based Cancer Immunotherapy by Antunes, Dinler A, Rigo, Maurício M, Freitas, Martiela V, Mendes, Marcus F A, Sinigaglia, Marialva, Lizée, Gregory, Kavraki, Lydia E, Selin, Liisa K, Cornberg, Markus, Vieira, Gustavo F

“…Immunotherapy has become one of the most promising avenues for cancer treatment, making use of the patient's own immune system to eliminate cancer cells…”
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Structural Modeling and Molecular Dynamics of the Immune Checkpoint Molecule HLA-G by Arns, Thais, Antunes, Dinler A, Abella, Jayvee R, Rigo, Maurício M, Kavraki, Lydia E, Giuliatti, Silvana, Donadi, Eduardo A

“…HLA-G is considered to be an immune checkpoint molecule, a function that is closely linked to the structure and dynamics of the different HLA-G isoforms…”
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Variation of modulation and expression of biomarkers associated with inflammation in bariatric surgery patients: A systematic review and meta-analysis by Machado, Cátia R., Braun, Amanda M., Ceolin, Jamile, Richter, Samanta A., Ribeiro, Mariele C., Santos, Leonardo D., Rigo, Maurício M., de Souza, Ana P.D., Padoin, Alexandre V., Alves, Letícia B., Mottin, Claudio C., Drumond Costa, Caroline A., Mundstock, Eduardo, Cañon-Montañez, Wilson, Ayala, Camila Ospina, Mattiello, Rita

“…Bariatric surgery is an effective intervention that causes a series of metabolic changes related to inflammatory processes; however, the variation of…”
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Respiratory syncytial virus reduces STAT3 phosphorylation in human memory CD8 T cells stimulated with IL-21 by Antunes, Krist Helen, Becker, André, Franceschina, Caroline, de Freitas, Deise do Nascimento, Lape, Isadora, da Cunha, Mariana D’Ávila, Leitão, Lidiane, Rigo, Mauricio M., Pinto, Leonardo Araújo, Stein, Renato T., de Souza, Ana Paula Duarte

“…Respiratory syncytial virus (RSV) is a common cause of childhood lower respiratory tract infections. The recent failure of a vaccine candidate based on…”
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GRPR antagonist protects from drug‐induced liver injury by impairing neutrophil chemotaxis and motility by Czepielewski, Rafael S., Jaeger, Natália, Marques, Pedro E., Antunes, Maísa M., Rigo, Maurício M., Alvarenga, Débora M., Pereira, Rafaela V., Silva, Rodrigo D., Lopes, Tiago G., Silva, Vinícius D., Porto, Bárbara N., Menezes, Gustavo B., Bonorino, Cristina

“…Drug‐induced liver injury (DILI) is a major cause of acute liver failure (ALF), where hepatocyte necrotic products trigger liver inflammation, release of CXC…”
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New insights into the in silico prediction of HIV protease resistance to nelfinavir by Antunes, Dinler A, Rigo, Maurício M, Sinigaglia, Marialva, de Medeiros, Rúbia M, Junqueira, Dennis M, Almeida, Sabrina E M, Vieira, Gustavo F

“…The Human Immunodeficiency Virus type 1 protease enzyme (HIV-1 PR) is one of the most important targets of antiretroviral therapy used in the treatment of AIDS…”
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Structural allele-specific patterns adopted by epitopes in the MHC-I cleft and reconstruction of MHC:peptide complexes to cross-reactivity assessment by Antunes, Dinler A, Vieira, Gustavo F, Rigo, Maurício M, Cibulski, Samuel P, Sinigaglia, Marialva, Chies, José A B

“…The immune system is engaged in a constant antigenic surveillance through the Major Histocompatibility Complex (MHC) class I antigen presentation pathway. This…”
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Lessons from molecular modeling human α-l-iduronidase by Figueiredo, Danieli Forgiarini, Antunes, Dinler A., Rigo, Maurício M., Mendes, Marcus F.A., Silva, Jader P., Mayer, Fabiana Q., Matte, Ursula, Giugliani, Roberto, Vieira, Gustavo F., Sinigaglia, Marialva

“…•Folding recognition provided the best alignment for IDUA homology modeling.•Stereochemical evaluations alone are poor indicators of structural…”
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S100B secretion is stimulated by IL-1β in glial cultures and hippocampal slices of rats: Likely involvement of MAPK pathway by de Souza, Daniela F, Leite, Marina C, Quincozes-Santos, André, Nardin, Patrícia, Tortorelli, Lucas S, Rigo, Maurício M, Gottfried, Carmem, Leal, Rodrigo B, Gonçalves, Carlos-Alberto

“…Abstract S100B is an astrocyte-derived cytokine implicated in the IL-1β-triggered cytokine cycle in Alzheimer's disease. However, the secretion of S100B…”
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Structural in silico analysis of cross-genotype-reactivity among naturally occurring HCV NS3-1073-variants in the context of HLA-A02:01 allele by Antunes, Dinler A., Rigo, Maurício M., Silva, Jader P., Cibulski, Samuel P., Sinigaglia, Marialva, Chies, José A.B., Vieira, Gustavo F.

“…Cellular immune response plays a central role in outcome of Hepatitis C Virus (HCV) infection. While specific T-cell responses are related to viral clearance,…”
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238-P Inference of good and bad HLA ligands through molecular dynamics approach by Rigo, Maurício M, Antunes, Dinler A, Chies, José A.B, Sinigaglia, Marialva, Vieira, Gustavo F

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S100B secretion is stimulated by IL-1beta in glial cultures and hippocampal slices of rats: Likely involvement of MAPK pathway by de Souza, Daniela F, Leite, Marina C, Quincozes-Santos, André, Nardin, Patrícia, Tortorelli, Lucas S, Rigo, Maurício M, Gottfried, Carmem, Leal, Rodrigo B, Gonçalves, Carlos-Alberto

“…S100B is an astrocyte-derived cytokine implicated in the IL-1beta-triggered cytokine cycle in Alzheimer's disease. However, the secretion of S100B following…”
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