Search Results - "Riggs, Michael W."

Genomic and virulence analysis of in vitro cultured Cryptosporidium parvum by Yarlett, Nigel, Morada, Mary, Schaefer, Deborah A, Ackman, Kevin, Carranza, Elizabeth, Baptista, Rodrigo de Paula, Riggs, Michael W, Kissinger, Jessica C

“…Recent advances in the in vitro cultivation of Cryptosporidium parvum using hollow fiber bioreactor technology (HFB) have permitted continuous growth of…”
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Necessity of Bumped Kinase Inhibitor Gastrointestinal Exposure in Treating Cryptosporidium Infection by Arnold, Samuel L. M., Choi, Ryan, Hulverson, Matthew A., Schaefer, Deborah A., Vinayak, Sumiti, Vidadala, Rama S. R., McCloskey, Molly C., Whitman, Grant R., Huang, Wenlin, Barrett, Lynn K., Ojo, Kayode K., Fan, Erkang, Maly, Dustin J., Riggs, Michael W., Striepen, Boris, Van Voorhis, Wesley C.

“…There is a substantial need for novel therapeutics to combat the widespread impact caused by Crytosporidium infection. However, there is a lack of knowledge as…”
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Novel Bumped Kinase Inhibitors Are Safe and Effective Therapeutics in the Calf Clinical Model for Cryptosporidiosis by Schaefer, Deborah A., Betzer, Dana P., Smith, Kylie D., Millman, Zachary G., Michalski, Hannah C., Menchaca, Sarah E., Zambriski, Jennifer A., Ojo, Kayode K., Hulverson, Matthew A., Arnold, Samuel L. M., Rivas, Kasey L., Vidadala, Rama S. R., Huang, Wenlin, Barrett, Lynn K., Maly, Dustin J., Fan, Erkang, Van Voorhis, Wesley C., Riggs, Michael W.

“…Cryptosporidiosis, caused by the apicomplexan parasite Cryptosporidium parvum, is a diarrheal disease that has produced a large global burden in mortality and…”
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A symbiotic bacterium of shipworms produces a compound with broad spectrum anti-apicomplexan activity by O'Connor, Roberta M, Nepveux V, Felix J, Abenoja, Jaypee, Bowden, Gregory, Reis, Patricia, Beaushaw, Josiah, Bone Relat, Rachel M, Driskell, Iwona, Gimenez, Fernanda, Riggs, Michael W, Schaefer, Deborah A, Schmidt, Eric W, Lin, Zhenjian, Distel, Daniel L, Clardy, Jon, Ramadhar, Timothy R, Allred, David R, Fritz, Heather M, Rathod, Pradipsinh, Chery, Laura, White, John

“…Apicomplexan parasites cause severe disease in both humans and their domesticated animals. Since these parasites readily develop drug resistance, development…”
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Neonatal Mouse Gut Metabolites Influence Cryptosporidium parvum Infection in Intestinal Epithelial Cells by VanDussen, Kelli L, Funkhouser-Jones, Lisa J, Akey, Marianna E, Schaefer, Deborah A, Ackman, Kevin, Riggs, Michael W, Stappenbeck, Thaddeus S, Sibley, L David

“…The protozoan parasite sp. is a leading cause of diarrheal disease in those with compromised or underdeveloped immune systems, particularly infants and…”
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Cathelicidin-like helminth defence molecules (HDMs): absence of cytotoxic, anti-microbial and anti-protozoan activities imply a specific adaptation to immune modulation by Thivierge, Karine, Cotton, Sophie, Schaefer, Deborah A, Riggs, Michael W, To, Joyce, Lund, Maria E, Robinson, Mark W, Dalton, John P, Donnelly, Sheila M

“…Host defence peptides (HDPs) are expressed throughout the animal and plant kingdoms. They have multifunctional roles in the defence against infectious agents…”
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Antibodies Fused to Innate Immune Molecules Reduce Initiation of Cryptosporidium parvum Infection in Mice by IMBODEN, Michael, RIGGS, Michael W, SCHAEFER, Deborah A, HOMAN, E. Jane, BREMEL, Robert D

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Immunofluorescence detection of Ecytonucleospora hepatopenaei (EHP) in Penaeus vannamei by Cho, Sungman, Schaefer, Deborah A., Mai, Hung N., Riggs, Michael W., Dhar, Arun K.

“…Hepatopancreatic microsporidiosis (HPM), caused by the microsporidium Ecytonucleospora hepatopenaei (EHP) leads to retarded growth and enhanced susceptibility…”
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Modelling Cryptosporidium infection in human small intestinal and lung organoids by Heo, Inha, Dutta, Devanjali, Schaefer, Deborah A., Iakobachvili, Nino, Artegiani, Benedetta, Sachs, Norman, Boonekamp, Kim E., Bowden, Gregory, Hendrickx, Antoni P. A., Willems, Robert J. L., Peters, Peter J., Riggs, Michael W., O’Connor, Roberta, Clevers, Hans

“…Stem-cell-derived organoids recapitulate in vivo physiology of their original tissues, representing valuable systems to model medical disorders such as…”
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Pharmacokinetics and Pharmacodynamics of Clofazimine for Treatment of Cryptosporidiosis by Zhang, Cindy X, Love, Melissa S, McNamara, Case W, Chi, Victor, Woods, Ashley K, Joseph, Sean, Schaefer, Deborah A, Betzer, Dana P, Riggs, Michael W, Iroh Tam, Pui-Ying, Van Voorhis, Wesley C, Arnold, Samuel L M

“…Infection with spp. can cause severe diarrhea, leading to long-term adverse impacts and even death in malnourished children and immunocompromised patients. The…”
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Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned by Choi, Ryan, Hulverson, Matthew A., Huang, Wenlin, Vidadala, Rama S.R., Whitman, Grant R., Barrett, Lynn K., Schaefer, Deborah A., Betzer, Dana P., Riggs, Michael W., Doggett, J. Stone, Hemphill, Andrew, Ortega-Mora, Luis Miguel, McCloskey, Molly C., Arnold, Samuel L.M., Hackman, Robert C., Marsh, Kennan C., Lynch, James J., Freiberg, Gail M., Leroy, Bruce E., Kempf, Dale J., Choy, Robert K.M., de Hostos, Eugenio L., Maly, Dustin J., Fan, Erkang, Ojo, Kayode K., Van Voorhis, Wesley C.

“…[Display omitted] •BKIs that target CDPK1 in apicomplexan parasites with a glycine gatekeeper are promising new therapeutics.•Numerous challenges have shaped…”
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Bumped-Kinase Inhibitors for Cryptosporidiosis Therapy by Hulverson, Matthew A., Vinayak, Sumiti, Choi, Ryan, Schaefer, Deborah A., Castellanos-Gonzalez, Alejandro, Vidadala, Rama S. R., Brooks, Carrie F., Herbert, Gillian T., Betzer, Dana P., Whitman, Grant R., Sparks, Hayley N., Arnold, Samuel L. M., Rivas, Kasey L., Barrett, Lynn K., White, A. Clinton, Maly, Dustin J., Riggs, Michael W., Striepen, Boris, Van Voorhis, Wesley C., Ojo, Kayode K.

“…Bumped kinase inhibitors (BKIs) of Cryptosporidium parvum calcium-dependent protein kinase 1 (CpCDPK1) are leading candidates for treatment of…”
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Comparison of Toxicities among Different Bumped Kinase Inhibitor Analogs for Treatment of Cryptosporidiosis by Hulverson, Matthew A, Choi, Ryan, Schaefer, Deborah A, Betzer, Dana P, McCloskey, Molly C, Whitman, Grant R, Huang, Wenlin, Lee, Sangun, Pranata, Andy, McLeod, Malcolm D, Marsh, Kennan C, Kempf, Dale J, LeRoy, Bruce E, Zafiratos, Mark T, Bielinski, Aimee L, Hackman, Robert C, Ojo, Kayode K, Arnold, Samuel L M, Barrett, Lynn K, Tzipori, Saul, Riggs, Michael W, Fan, Erkang, Van Voorhis, Wesley C

“…Recent advances on the development of bumped kinase inhibitors for treatment of cryptosporidiosis have focused on the 5-aminopyrazole-4-carboxamide scaffold,…”
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Extended-spectrum antiprotozoal bumped kinase inhibitors: A review by Van Voorhis, Wesley C., Doggett, J. Stone, Parsons, Marilyn, Hulverson, Matthew A., Choi, Ryan, Arnold, Samuel L.M., Riggs, Michael W., Hemphill, Andrew, Howe, Daniel K., Mealey, Robert H., Lau, Audrey O.T., Merritt, Ethan A., Maly, Dustin J., Fan, Erkang, Ojo, Kayode K.

“…Many life-cycle processes in parasites are regulated by protein phosphorylation. Hence, disruption of essential protein kinase function has been explored for…”
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One health therapeutics: Target-Based drug development for cryptosporidiosis and other apicomplexa diseases by Van Voorhis, Wesley C., Hulverson, Matthew A., Choi, Ryan, Huang, Wenlin, Arnold, Samuel L.M., Schaefer, Deborah A., Betzer, Dana P., Vidadala, Rama S.R., Lee, Sangun, Whitman, Grant R., Barrett, Lynn K., Maly, Dustin J., Riggs, Michael W., Fan, Erkang, Kennedy, Thomas J., Tzipori, Saul, Doggett, J. Stone, Winzer, Pablo, Anghel, Nicoleta, Imhof, Dennis, Müller, Joachim, Hemphill, Andrew, Ferre, Ignacio, Sanchez-Sanchez, Roberto, Ortega-Mora, Luis Miguel, Ojo, Kayode K.

“…This is a review of the development of bumped-kinase inhibitors (BKIs) for the therapy of One Health parasitic apicomplexan diseases. Many apicomplexan…”
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Advances in bumped kinase inhibitors for human and animal therapy for cryptosporidiosis by Hulverson, Matthew A., Choi, Ryan, Arnold, Samuel L.M., Schaefer, Deborah A., Hemphill, Andrew, McCloskey, Molly C., Betzer, Dana P., Müller, Joachim, Vidadala, Rama S.R., Whitman, Grant R., Rivas, Kasey L., Barrett, Lynn K., Hackman, Robert C., Love, Melissa S., McNamara, Case W., Shaughnessy, Thomas K., Kondratiuk, Alison, Kurnick, Matthew, Banfor, Patricia N., Lynch, James J., Freiberg, Gail M., Kempf, Dale J., Maly, Dustin J., Riggs, Michael W., Ojo, Kayode K., Van Voorhis, Wesley C.

“…[Display omitted] •Bumpked kinase inhibitor (BKI) 1369 selectively targets Cryptosporidium parvum calcium-dependent protein kinase 1.•It is more potent than…”
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5-Aminopyrazole-4-Carboxamide-Based Compounds Prevent the Growth of Cryptosporidium parvum by Huang, Wenlin, Choi, Ryan, Hulverson, Matthew A, Zhang, Zhongsheng, McCloskey, Molly C, Schaefer, Deborah A, Whitman, Grant R, Barrett, Lynn K, Vidadala, Rama Subba Rao, Riggs, Michael W, Maly, Dustin J, Van Voorhis, Wesley C, Ojo, Kayode K, Fan, Erkang

“…calcium-dependent protein kinase 1 ( CDPK1) is a promising target for drug development against cryptosporidiosis. We report a series of low-nanomolar CDPK1…”
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Efficacy of Monoclonal Antibodies against Defined Antigens for Passive Immunotherapy of Chronic Gastrointestinal Cryptosporidiosis by RIGGS, Michael W, SCHAEFER, Deborah A, KAPIL, Sushila J, BARLEY-MALONEY, Lise, PERRYMAN, Lance E

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Characterization of a Low Molecular Weight Glycolipid Antigen from Cryptosporidium parvum by Priest, Jeffrey W., Mehlert, Angela, Arrowood, Michael J., Riggs, Michael W., Ferguson, Michael A.J.

“…Cryptosporidium parvum, an Apicomplexan parasite of the mammalian gut epithelium, causes a diarrheal illness in a wide range of hosts and is transmitted by…”
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The secreted effector protein EspZ is essential for virulence of rabbit enteropathogenic Escherichia coli by Wilbur, John Scott, Byrd, Wyatt, Ramamurthy, Shylaja, Ledvina, Hannah E, Khirfan, Khaldoon, Riggs, Michael W, Boedeker, Edgar C, Vedantam, Gayatri, Viswanathan, V K

“…Attaching and effacing (A/E) pathogens adhere intimately to intestinal enterocytes and efface brush border microvilli. A key virulence strategy of A/E…”
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