Search Results - "Riggs, Matthew"

When Learn/Confirm Leads to Expand/Understand: The Expanding Role of Quantitative Systems Pharmacology in the Betterment of Therapeutics Development by Riggs, Matthew M.

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Pharmacometrics and systems pharmacology for metabolic bone diseases by Riggs, Matthew M., Cremers, Serge

“…Mathematical modelling and simulation (M&S) of drug concentrations, pharmacologic effects and the (patho)physiologic systems within which they interact can be…”
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Quantification of the Impact of Partition Coefficient Prediction Methods on Physiologically Based Pharmacokinetic Model Output Using a Standardized Tissue Composition by Utsey, Kiersten, Gastonguay, Madeleine S, Russell, Sean, Freling, Reed, Riggs, Matthew M, Elmokadem, Ahmed

“…Tissue:plasma partition coefficients are key parameters in physiologically based pharmacokinetic (PBPK) models, yet the coefficients are challenging to measure…”
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A physiologically based mathematical model of integrated calcium homeostasis and bone remodeling by Peterson, Mark C, Riggs, Matthew M

“…Abstract Bone biology is physiologically complex and intimately linked to calcium homeostasis. The literature provides a wealth of qualitative and/or…”
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Quantitative Systems Pharmacology and Physiologically‐Based Pharmacokinetic Modeling With mrgsolve: A Hands‐On Tutorial by Elmokadem, Ahmed, Riggs, Matthew M., Baron, Kyle T.

“…mrgsolve is an open‐source R package available on the Comprehensive R Archive Network. It combines R and C++ coding for simulation from hierarchical, ordinary…”
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Toward Progress in Quantitative Translational Medicine: A Call to Action by Venkatakrishnan, Karthik, Zheng, Songmao, Musante, Cynthia J., Jin, Jin Y., Riggs, Matthew M., Krishnaswami, Sriram, Visser, Sandra A.G.

“…Quantitative translational medicine (QTM) is envisioned as a multifaceted discipline that will galvanize the path from idea to medicine through quantitative…”
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Open Systems Pharmacology Community—An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences by Lippert, Jörg, Burghaus, Rolf, Edginton, Andrea, Frechen, Sebastian, Karlsson, Mats, Kovar, Andreas, Lehr, Thorsten, Milligan, Peter, Nock, Valerie, Ramusovic, Sergej, Riggs, Matthew, Schaller, Stephan, Schlender, Jan, Schmidt, Stephan, Sevestre, Michaël, Sjögren, Erik, Solodenko, Juri, Staab, Alexander, Teutonico, Donato

“…Open Systems Pharmacology is a community that develops, qualifies, and shares professional open source software tools and models in a collaborative…”
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Training the next generation of pharmacometric modelers: a multisector perspective by Bonate, Peter L., Barrett, Jeffrey S., Ait-Oudhia, Sihem, Brundage, Richard, Corrigan, Brian, Duffull, Stephen, Gastonguay, Marc, Karlsson, Mats O., Kijima, Shinichi, Krause, Andreas, Lovern, Mark, Riggs, Matthew M., Neely, Michael, Ouellet, Daniele, Plan, Elodie L., Rao, Gauri G., Standing, Joseph, Wilkins, Justin, Zhu, Hao

“…The current demand for pharmacometricians outmatches the supply provided by academic institutions and considerable investments are made to develop the…”
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Correction to: Training the next generation of pharmacometric modelers: a multisector perspective by Bonate, Peter L., Barrett, Jeffrey S., Ait-Oudhia, Sihem, Brundage, Richard, Corrigan, Brian, Duffull, Stephen, Gastonguay, Marc, Karlsson, Mats O., Kijima, Shinichi, Krause, Andreas, Lovern, Mark, Riggs, Matthew M., Neely, Michael, Ouellet, Daniele, Plan, Elodie L., Rao, Gauri G., Standing, Joseph, Wilkins, Justin, Zhu, Hao

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Low‐dose empagliflozin as adjunct‐to‐insulin therapy in type 1 diabetes: A valid modelling and simulation analysis to confirm efficacy by Perkins, Bruce A., Soleymanlou, Nima, Rosenstock, Julio, Skyler, Jay S., Laffel, Lori M., Liesenfeld, Karl‐Heinz, Neubacher, Dietmar, Riggs, Matthew M., Johnston, Curtis K., Eudy‐Byrne, Rena J., Elmokadem, Ahmed, George, Jyothis T., Marquard, Jan, Nock, Valerie

“…Aim To confirm the observed reduction in HbA1c for the 2.5 mg dose in EASE‐3 by modelling and simulation analyses. Materials and methods Independent of data…”
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A Model-Informed Drug Development (MIDD) Approach for a Low Dose of Empagliflozin in Patients with Type 1 Diabetes by Johnston, Curtis K, Eudy-Byrne, Rena J, Elmokadem, Ahmed, Nock, Valerie, Marquard, Jan, Soleymanlou, Nima, Riggs, Matthew M, Liesenfeld, Karl-Heinz

“…In clinical trials, sodium-glucose co-transporter (SGLT) inhibitor use as adjunct to insulin therapy in type 1 diabetes (T1D) provides glucometabolic benefits…”
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Cardiopulmonary resuscitation (CPR) psychomotor skills of laypeople, as affected by training interventions, number of times trained and retention testing intervals: A dataset derived from a systematic review by Riggs, Matthew, Franklin, Richard, Saylany, Lua

“…This article is a companion to a systematic review, entitled, Associations between cardiopulmonary resuscitation (CPR) knowledge, self-efficacy, training…”
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Model-based meta-analysis for comparing Vitamin D2 and D3 parent-metabolite pharmacokinetics by Ocampo-Pelland, Alanna S., Gastonguay, Marc R., Riggs, Matthew M.

“…Association of Vitamin D (D3 & D2) and its 25OHD metabolite (25OHD3 & 25OHD2) exposures with various diseases is an active research area. D3 and D2…”
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Model-based meta-analysis for development of a population-pharmacokinetic (PPK) model for Vitamin D3 and its 25OHD3 metabolite using both individual and arm-level data by Ocampo-Pelland, Alanna S., Gastonguay, Marc R., French, Jonathan F., Riggs, Matthew M.

“…Clinical studies investigating relationships between D3 and 25OHD3 vary in dosing regimen, assays, demographics, and control of exogenous D3. This leads to…”
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A model of fracture risk used to examine the link between bone mineral density and the impact of different therapeutic mechanisms on fracture outcomes in patients with osteoporosis by Eudy-Byrne, Rena J., Gillespie, William, Riggs, Matthew M., Gastonguay, Marc R.

“…A hazard model of fracture was developed using individual patient data (IPD) from the NHANES (2005–2008) database and summary-level data from an aggregate…”
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Population pharmacokinetics of empagliflozin, a sodium glucose cotransporter 2 inhibitor, in patients with type 2 diabetes by Riggs, Matthew M., Staab, Alexander, Seman, Leo, MacGregor, Thomas R., Bergsma, Timothy T., Gastonguay, Marc R., Macha, Sreeraj

“…Data from five randomized, placebo‐controlled, multiple oral dose studies of empagliflozin in patients with type 2 diabetes mellitus (T2DM; N = 974; 1–100 mg…”
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A Priori Identifiability of Target-Mediated Drug Disposition Models and Approximations by Eudy, Rena J., Riggs, Matthew M., Gastonguay, Marc R.

“…A priori identifiability of mathematical models assures that for a given input/output experiment, the parameter set has one unique solution within a defined…”
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Multiscale Physiology-Based Modeling of Mineral Bone Disorder in Patients With Impaired Kidney Function by Riggs, Matthew M., Peterson, Mark C., Gastonguay, Marc R.

“…A physiologically based, multiscale model of calcium homeostasis and bone remodeling was used to describe the impact of progressive loss of kidney function…”
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Exposure−response modelling for empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, in patients with type 2 diabetes by Riggs, Matthew M., Seman, Leo J., Staab, Alexander, MacGregor, Thomas R., Gillespie, William, Gastonguay, Marc R., Woerle, Hans J., Macha, Sreeraj

“…Aims To provide model‐based clinical development decision support including dose selection guidance for empagliflozin, an orally administered sodium glucose…”
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Facilitating pharmacometric workflow with the metrumrg package for R by Bergsma, Timothy T, Knebel, William, Fisher, Jeannine, Gillespie, William R, Riggs, Matthew M, Gibiansky, Leonid, Gastonguay, Marc R

“…Abstract metrumrg is an R package that facilitates workflow for the discipline of pharmacometrics. Support is provided for data preparation, modeling,…”
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