Search Results - "Riggi, Nicolò"

Ewing’s Sarcoma by Riggi, Nicolò, Suvà, Mario L, Stamenkovic, Ivan

“…Ewing’s sarcoma, an aggressive cancer of bone and soft tissue, primarily affects children and young adults. A t(11;22) translocation is noted in 85 to 90% of…”
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The Biology of Ewing sarcoma by Riggi, Nicolò, Stamenkovic, Ivan

“…Abstract Sarcomas account for less than 10% of all human malignancies that are believed to originate from as yet poorly defined mesenchymal progenitor cells…”
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'Mini-colons' shed light on cancer progression by Riggi, Nicolò, e Melo, Felipe de Sousa

“…To investigate the effect of frequently occurring mutations associated with colorectal cancer, the authors built such mini-colons out of mouse intestinal…”
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EWSR1-ATF1 dependent 3D connectivity regulates oncogenic and differentiation programs in Clear Cell Sarcoma by Möller, Emely, Praz, Viviane, Rajendran, Sanalkumar, Dong, Rui, Cauderay, Alexandra, Xing, Yu-Hang, Lee, Lukuo, Fusco, Carlo, Broye, Liliane C., Cironi, Luisa, Iyer, Sowmya, Rengarajan, Shruthi, Awad, Mary E., Naigles, Beverly, Letovanec, Igor, Ormas, Nicola, Finzi, Giovanna, La Rosa, Stefano, Sessa, Fausto, Chebib, Ivan, Petur Nielsen, G., Digklia, Antonia, Spentzos, Dimitrios, Cote, Gregory M., Choy, Edwin, Aryee, Martin, Stamenkovic, Ivan, Boulay, Gaylor, Rivera, Miguel N., Riggi, Nicolò

“…Oncogenic fusion proteins generated by chromosomal translocations play major roles in cancer. Among them, fusions between EWSR1 and transcription factors…”
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Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma by Jerby-Arnon, Livnat, Neftel, Cyril, Shore, Marni E., Weisman, Hannah R., Mathewson, Nathan D., McBride, Matthew J., Haas, Brian, Izar, Benjamin, Volorio, Angela, Boulay, Gaylor, Cironi, Luisa, Richman, Alyssa R., Broye, Liliane C., Gurski, Joseph M., Luo, Christina C., Mylvaganam, Ravindra, Nguyen, Lan, Mei, Shaolin, Melms, Johannes C., Georgescu, Christophe, Cohen, Ofir, Buendia-Buendia, Jorge E., Segerstolpe, Asa, Sud, Malika, Cuoco, Michael S., Labes, Danny, Gritsch, Simon, Zollinger, Daniel R., Ortogero, Nicole, Beechem, Joseph M., Petur Nielsen, G., Chebib, Ivan, Nguyen-Ngoc, Tu, Montemurro, Michael, Cote, Gregory M., Choy, Edwin, Letovanec, Igor, Cherix, Stéphane, Wagle, Nikhil, Sorger, Peter K., Haynes, Alex B., Mullen, John T., Stamenkovic, Ivan, Rivera, Miguel N., Kadoch, Cigall, Wucherpfennig, Kai W., Rozenblatt-Rosen, Orit, Suvà, Mario L., Riggi, Nicolò, Regev, Aviv

“…Synovial sarcoma (SyS) is an aggressive neoplasm driven by the SS18–SSX fusion, and is characterized by low T cell infiltration. Here, we studied the…”
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Identification of Cancer Stem Cells in Ewing's Sarcoma by SUVA, Mario-Luca, RIGGI, Nicolò, OSTERHELD, Maria-Chiara, GUILLOU, Louis, STAMENKOVIC, Ivan, STEHLE, Jean-Christophe, BAUMER, Karine, TERCIER, Stéphane, JOSEPH, Jean-Marc, SUVA, Domizio, CLEMENT, Virginie, PROVERO, Paolo, CIRONI, Luisa

“…Cancer stem cells that display tumor-initiating properties have recently been identified in several distinct types of malignancies, holding promise for more…”
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EWS-FLI-1 Expression Triggers a Ewing's Sarcoma Initiation Program in Primary Human Mesenchymal Stem Cells by RIGGI, Nicolo, SUVA, Mario-Luca, STAMENKOVIC, Ivan, SUVA, Domizio, CIRONI, Luisa, PROVERO, Paolo, TERCIER, Stéphane, JOSEPH, Jean-Marc, STEHLE, Jean-Christophe, BAUMER, Karine, KINDLER, Vincent

“…Ewing's sarcoma family tumors (ESFT) express the EWS-FLI-1 fusion gene generated by the chromosomal translocation t(11;22)(q24;q12). Expression of the…”
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EZH2 is essential for glioblastoma cancer stem cell maintenance by Suvà, Mario-Luca, Riggi, Nicolò, Janiszewska, Michalina, Radovanovic, Ivan, Provero, Paolo, Stehle, Jean-Christophe, Baumer, Karine, Le Bitoux, Marie-Aude, Marino, Denis, Cironi, Luisa, Marquez, Victor E, Clément, Virginie, Stamenkovic, Ivan

“…Overexpression of the polycomb group protein enhancer of zeste homologue 2 (EZH2) occurs in diverse malignancies, including prostate cancer, breast cancer, and…”
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Clear cell sarcoma: state-of-the art and perspectives by Wetterwald, Laureline, Riggi, Nicolò, Kyriazoglou, Anastasios, Dei Tos, Giovanni, Dei Tos, Angelo, Digklia, Antonia

“…Clear cell sarcoma (CCS) is an ultrarare soft tissue sarcoma (STS) with a poor prognosis due to its propensity to metastasize and its low chemosensitivity. The…”
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DisP-seq reveals the genome-wide functional organization of DNA-associated disordered proteins by Xing, Yu-Hang, Dong, Rui, Lee, Lukuo, Rengarajan, Shruthi, Riggi, Nicolò, Boulay, Gaylor, Rivera, Miguel N.

“…Intrinsically disordered regions (IDRs) in DNA-associated proteins are known to influence gene regulation, but their distribution and cooperative functions in…”
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Ewing's Sarcoma. Reply by Riggi, Nicolò, Suvà, Mario L, Stamenkovic, Ivan

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EWS-FLI-1 modulates miRNA145 and SOX2 expression to initiate mesenchymal stem cell reprogramming toward Ewing sarcoma cancer stem cells by Riggi, Nicolò, Suvà, Mario-Luca, De Vito, Claudio, Provero, Paolo, Stehle, Jean-Christophe, Baumer, Karine, Cironi, Luisa, Janiszewska, Michalina, Petricevic, Tanja, Suvà, Domizio, Tercier, Stéphane, Joseph, Jean-Marc, Guillou, Louis, Stamenkovic, Ivan

“…Cancer stem cells (CSCs) display plasticity and self-renewal properties reminiscent of normal tissue stem cells, but the events responsible for their emergence…”
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Comprehensive Genetic Landscape of Uveal Melanoma by Whole-Genome Sequencing by Royer-Bertrand, Beryl, Torsello, Matteo, Rimoldi, Donata, El Zaoui, Ikram, Cisarova, Katarina, Pescini-Gobert, Rosanna, Raynaud, Franck, Zografos, Leonidas, Schalenbourg, Ann, Speiser, Daniel, Nicolas, Michael, Vallat, Laureen, Klein, Robert, Leyvraz, Serge, Ciriello, Giovanni, Riggi, Nicolò, Moulin, Alexandre P., Rivolta, Carlo

“…Uveal melanoma (UM) is a rare intraocular tumor that, similar to cutaneous melanoma, originates from melanocytes. To gain insights into its genetics, we…”
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Development of Ewing's sarcoma from primary bone marrow- derived mesenchymal progenitor cells by RIGGI, Mcolo, CIRONI, Luisa, PROVERO, Paolo, SUVA, Mario-Luca, KALOULIS, Konstantinos, GARCIA-ECHEVERRIA, Carlos, HOFFMANN, Francesco, TRUMPP, Andreas, STAMENKOVIC, Ivan

“…Ewing's sarcoma is a member of Ewing's family tumors (EFTs) and the second most common solid bone and soft tissue malignancy of children and young adults. It…”
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EWS-FLI1 Utilizes Divergent Chromatin Remodeling Mechanisms to Directly Activate or Repress Enhancer Elements in Ewing Sarcoma by Riggi, Nicolò, Knoechel, Birgit, Gillespie, Shawn M., Rheinbay, Esther, Boulay, Gaylor, Suvà, Mario L., Rossetti, Nikki E., Boonseng, Wannaporn E., Oksuz, Ozgur, Cook, Edward B., Formey, Aurélie, Patel, Anoop, Gymrek, Melissa, Thapar, Vishal, Deshpande, Vikram, Ting, David T., Hornicek, Francis J., Nielsen, G. Petur, Stamenkovic, Ivan, Aryee, Martin J., Bernstein, Bradley E., Rivera, Miguel N.

“…The aberrant transcription factor EWS-FLI1 drives Ewing sarcoma, but its molecular function is not completely understood. We find that EWS-FLI1 reprograms gene…”
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Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma by RIGGI, Nicolo, CIRONI, Luisa, PROVERO, Paolo, SUVA, Mario-Luca, STEHLE, Jean-Christophe, BAUMER, Karine, GUILLOU, Louis, STAMENKOVIC, Ivan

“…A subset of sarcomas is associated with specific chromosomal translocations that give rise to fusion genes believed to participate in transformation and…”
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Genomic and transcriptomic landscape of conjunctival melanoma by Cisarova, Katarina, Folcher, Marc, El Zaoui, Ikram, Pescini-Gobert, Rosanna, Peter, Virginie G, Royer-Bertrand, Beryl, Zografos, Leonidas, Schalenbourg, Ann, Nicolas, Michael, Rimoldi, Donata, Leyvraz, Serge, Riggi, Nicolò, Moulin, Alexandre P, Rivolta, Carlo

“…Conjunctival melanoma (CJM) is a rare but potentially lethal and highly-recurrent cancer of the eye. Similar to cutaneous melanoma (CM), it originates from…”
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EWS-WT1 fusion isoforms establish oncogenic programs and therapeutic vulnerabilities in desmoplastic small round cell tumors by Boulay, Gaylor, Broye, Liliane C., Dong, Rui, Iyer, Sowmya, Sanalkumar, Rajendran, Xing, Yu-Hang, Buisson, Rémi, Rengarajan, Shruthi, Naigles, Beverly, Duc, Benoît, Volorio, Angela, Awad, Mary E., Renella, Raffaele, Chebib, Ivan, Nielsen, G. Petur, Choy, Edwin, Cote, Gregory M., Zou, Lee, Letovanec, Igor, Stamenkovic, Ivan, Rivera, Miguel N., Riggi, Nicolò

“…EWS fusion oncoproteins underlie several human malignancies including Desmoplastic Small Round Cell Tumor (DSRCT), an aggressive cancer driven by EWS-WT1…”
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IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells by Cironi, Luisa, Riggi, Nicolò, Provero, Paolo, Wolf, Natalie, Suvà, Mario-Luca, Suvà, Domizio, Kindler, Vincent, Stamenkovic, Ivan

“…The EWS-FLI-1 fusion protein is associated with 85-90% of Ewing's sarcoma family tumors (ESFT), the remaining 10-15% of cases expressing chimeric genes…”
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TWIST1 expression is associated with high-risk neuroblastoma and promotes primary and metastatic tumor growth by Sepporta, Maria-Vittoria, Praz, Viviane, Balmas Bourloud, Katia, Joseph, Jean-Marc, Jauquier, Nicolas, Riggi, Nicolò, Nardou-Auderset, Katya, Petit, Audrey, Scoazec, Jean-Yves, Sartelet, Hervé, Renella, Raffaele, Mühlethaler-Mottet, Annick

“…The embryonic transcription factors TWIST1/2 are frequently overexpressed in cancer, acting as multifunctional oncogenes. Here we investigate their role in…”
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