Search Results - "Riffell, Jenna"

Tankyrase-targeted therapeutics: expanding opportunities in the PARP family by Riffell, Jenna L., Lord, Christopher J., Ashworth, Alan

“…Key Points The tankyrases TANK1 and TANK2 are members of the poly(ADP-ribose) polymerase (PARP) superfamily of enzymes that catalyse the transfer of many…”
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CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours by Costa-Cabral, Sara, Brough, Rachel, Konde, Asha, Aarts, Marieke, Campbell, James, Marinari, Eliana, Riffell, Jenna, Bardelli, Alberto, Torrance, Christopher, Lord, Christopher J, Ashworth, Alan

“…Activating KRAS mutations are found in approximately 20% of human cancers but no RAS-directed therapies are currently available. Here we describe a novel,…”
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Correction: Correction: CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours by Costa-Cabral, Sara, Brough, Rachel, Konde, Asha, Aarts, Marieke, Campbell, James, Marinari, Eliana, Riffell, Jenna, Bardelli, Alberto, Torrance, Christopher, Lord, Christopher J, Ashworth, Alan

“…[This corrects the article DOI: 10.1371/journal.pone.0176578.]…”
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Effects of chemical manipulation of mitotic arrest and slippage on cancer cell survival and proliferation by Riffell, Jenna L, Zimmerman, Carla, Khong, Anthony, McHardy, Lianne M, Roberge, Michel

“…Microtubule-targeting cancer therapies interfere with mitotic spindle dynamics and block cells in mitosis by activating the mitotic checkpoint. Cells arrested…”
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Caspase-3-dependent mitotic checkpoint inactivation by the small-molecule inducers of mitotic slippage SU6656 and geraldol by Riffell, Jenna L, Jänicke, Reiner U, Roberge, Michel

“…Microtubule-targeting cancer drugs such as paclitaxel block cell-cycle progression at mitosis by prolonged activation of the mitotic checkpoint. Cells can…”
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Crystallization of Aqueous Inorganic−Malonic Acid Particles:  Nucleation Rates, Dependence on Size, and Dependence on the Ammonium-to-Sulfate Ratio by Parsons, Matthew T, Riffell, Jenna L, Bertram, Allan K

“…Using an electrodynamic balance, we determined the relative humidity (RH) at which aqueous inorganic−malonic acid particles crystallized, with ammonium sulfate…”
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Correction: CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours by Costa-Cabral, Sara, Brough, Rachel, Konde, Asha, Aarts, Marieke, Campbell, James, Marinari, Eliana, Riffell, Jenna, Bardelli, Alberto, Torrance, Christopher, Lord, Christopher J, Ashworth, Alan

“…[This corrects the article DOI: 10.1371/journal.pone.0149099.]…”
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Correction: CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours by Costa-Cabral, Sara, Brough, Rachel, Konde, Asha, Aarts, Marieke, Campbell, James, Marinari, Eliana, Riffell, Jenna, Bardelli, Alberto, Torrance, Christopher, Lord, Christopher J, Ashworth, Alan

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Substrate Binding and Active Site Residues in RNases E and G: ROLE OF THE 5'-SENSOR by Garrey, Stephen M, Blech, Michaela, Riffell, Jenna L, Hankins, Janet S, Stickney, Leigh M, Diver, Melinda, Hsu, Ying-Han Roger, Kunanithy, Vitharani, Mackie, George A

“…The paralogous endoribonucleases, RNase E and RNase G, play major roles in intracellular RNA metabolism in Escherichia coli and related organisms. To assay the…”
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Spirastrellolides C to G:  Macrolides Obtained from the Marine Sponge Spirastrella coccinea by Williams, David E, Keyzers, Robert A, Warabi, Kaoru, Desjardine, Kelsey, Riffell, Jenna L, Roberge, Michel, Andersen, Raymond J

“…Five new macrolides, spirastrellolides C (3) to G (7), have been isolated from extracts of the marine sponge Spirastrella coccinea collected in Dominica. Their…”
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Synthetic Approaches to the Microtubule-Stabilizing Sponge Alkaloid Ceratamine A and Desbromo Analogues by Nodwell, Matt, Pereira, Alban, Riffell, Jenna L, Zimmerman, Carla, Patrick, Brian O, Roberge, Michel, Andersen, Raymond J

“…Two synthetic approaches to the microtubule-stabilizing ceratamine alkaloids are described. The first approach involved attempts to graft an aminoimidazole…”
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Synthesis of Antimitotic Analogs of the Microtubule Stabilizing Sponge Alkaloid Ceratamine A by Nodwell, Matt, Riffell, Jenna L, Roberge, Michel, Andersen, Raymond J

“…Antimitotic analogs of the microtubule stabilizing sponge alkaloid ceratamine A (1) have been synthesized starting from tribromoimidazole. A key step in the…”
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Substrate Binding and Active Site Residues in RNases E and G by Garrey, Stephen M., Blech, Michaela, Riffell, Jenna L., Hankins, Janet S., Stickney, Leigh M., Diver, Melinda, Hsu, Ying-Han Roger, Kunanithy, Vitharani, Mackie, George A.

“…The paralogous endoribonucleases, RNase E and RNase G, play major roles in intracellular RNA metabolism in Escherichia coli and related organisms. To assay the…”
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Effects of chemical manipulation of mitotic arrest and slippage on cancer cell survival and proliferation by Riffell, Jenna L., Zimmerman, Carla, Khong, Anthony, McHardy, Lianne M., Roberge, Michel

“…Microtubule-targeting cancer therapies interfere with mitotic spindle dynamics and block cells in mitosis by activating the mitotic checkpoint. Cells arrested…”
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Abstract B24: Using KRAS synthetic lethality to design novel therapeutic approaches to cancer by Costa-Cabral, Sara, Marinari, Eliana, Aarts, Marieke, Riffell, Jenna L., Torrence, Christopher, Lord, Christopher L., Ashworth, Alan

“…Background: KRAS is among the most commonly mutated human cancer genes, and is mutated in approximately 20% of human tumors. In colorectal cancer KRAS mutation…”
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