Search Results - "Riffel, K."

Machine Learning for Real-Time Fuel Consumption Prediction and Driving Profile Classification Based on ECU Data by Canal, Rafael, Riffel, Felipe K., Gracioli, Giovani

“…Data extracted directly from a vehicle's electronic control unit (ECU) play a crucial role in the automotive industry because they contain valuable information…”
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Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation by Pearce, Robin E, Gaedigk, Roger, Twist, Greyson P, Dai, Hongying, Riffel, Amanda K, Leeder, J Steven, Gaedigk, Andrea

“…Although CYP2B6 catalyzes the biotransformation of many drugs used clinically for children and adults, information regarding the effects of development on…”
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Constellation: a tool for rapid, automated phenotype assignment of a highly polymorphic pharmacogene, CYP2D6, from whole-genome sequences by Twist, Greyson P, Gaedigk, Andrea, Miller, Neil A, Farrow, Emily G, Willig, Laurel K, Dinwiddie, Darrell L, Petrikin, Josh E, Soden, Sarah E, Herd, Suzanne, Gibson, Margaret, Cakici, Julie A, Riffel, Amanda K, Leeder, J Steven, Dinakarpandian, Deendayal, Kingsmore, Stephen F

“…An important component of precision medicine—the use of whole-genome sequencing (WGS) to guide lifelong healthcare—is electronic decision support to inform…”
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Cotinine in human placenta predicts induction of gene expression in fetal tissues by Vyhlidal, Carrie A, Riffel, Amanda K, Haley, Kathleen J, Sharma, Sunita, Dai, Hongying, Tantisira, Kelan G, Weiss, Scott T, Leeder, J Steven

“…Maternal cigarette smoking during pregnancy is associated with increased risk of perinatal morbidity and mortality. However, the mechanisms underlying adverse…”
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Regulation of the CYP3A4 and CYP3A7 promoters by members of the nuclear factor I transcription factor family by Riffel, Amanda K, Schuenemann, Eric, Vyhlidal, Carrie A

“…Despite the established interindividual variability and ontogeny of the CYP3A enzymes, the most abundant phase I drug-metabolizing enzymes in human liver and…”
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Effect of wire electrode and shielding gas compositions on the mechanical properties of DOMEX 700 steel welded by the GMAW-P process by Haupt, W., Riffel, K. C., Israel, C. L., Silva, R. H. G., Reguly, A.

“…High-strength steels such as DOMEX 700 combine high mechanical strength and great ductility. However, when processed by welding their microstructure could…”
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Synthesis, characterization, and first successful monkey imaging studies of metabotropic glutamate receptor subtype 5 (mGluR5) PET radiotracers by Hamill, Terence G., Krause, Stephen, Ryan, Christine, Bonnefous, Celine, Govek, Steve, Seiders, T. Jon, Cosford, Nicholas D.P., Roppe, Jeffrey, Kamenecka, Ted, Patel, Shil, Gibson, Raymond E., Sanabria, Sandra, Riffel, Kerry, Eng, Waisi, King, Christopher, Yang, Xiaoqing, Green, Mitchell D., O'malley, Stacey S., Hargreaves, Richard, Burns, H. Donald

“…Three metabotropic glutamate receptor subtype 5 (mGluR5) PET tracers have been labeled with either carbon‐11 or fluorine‐18 and their in vitro and in vivo…”
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Oxidative stress parameters in juvenile Brazilian flounder Paralichthys orbignyanus (Valenciennes, 1839) (Pleuronectiformes: Paralichthyidae) exposed to cold and heat shocks by Garcia, Luciano de O., Okamoto, Marcelo H., Riffel, Ana Paula K., Saccol, Etiane M., Pavanato, Maria A., Sampaio, Luís André N.

“…The aim of this study was to determine oxidative stress parameters in the liver and gill of Brazilian flounder juveniles (307.0 ± 16.0 g and 30.0 ± 4.0 cm)…”
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CYP2D6 Haplotype Determination Using Long Range Allele-Specific Amplification: Resolution of a Complex Genotype and a Discordant Genotype Involving the CYP2D659 Allele by Gaedigk, Andrea, Riffel, Amanda K, Leeder, J Steven

“…Cytochrome P450 (CYP) 2D6, a major contributor to the metabolism and bioactivation of many clinically used drugs, is encoded by a complex, highly polymorphic…”
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CYP2D7 Sequence Variation Interferes with TaqMan CYP2D615 and 35 Genotyping by Riffel, Amanda K., Dehghani, Mehdi, Hartshorne, Toinette, Floyd, Kristen C., Leeder, J. Steven, Rosenblatt, Kevin P., Gaedigk, Andrea

“…TaqMan™ genotyping assays are widely used to genotype CYP2D6 , which encodes a major drug metabolizing enzyme. Assay design for CYP2D6 can be challenging owing…”
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Humic acid and moderate hypoxia alter oxidative and physiological parameters in different tissues of silver catfish (Rhamdia quelen) by Riffel, Ana P. K., Saccol, Etiane M. H., Finamor, Isabela A., Ourique, Giovana M., Gressler, Luciane T., Parodi, Thaylise V., Goulart, Luis O. R., Llesuy, Susana F., Baldisserotto, Bernardo, Pavanato, Maria A.

“…Aquatic animals are naturally exposed simultaneously to environments with different concentrations of humic acid (HA) and seasonal or daily variations of…”
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Addition of Lippia alba (Mill) N. E. Brown essential oil to the diet of the silver catfish: An analysis of growth, metabolic and blood parameters and the antioxidant response by Saccol, Etiane M.H., Uczay, Juliano, Pês, Tanise S., Finamor, Isabela A., Ourique, Giovana M., Riffel, Ana P.K., Schmidt, Denise, Caron, Braulio O., Heinzmann, Berta M., Llesuy, Susana F., Lazzari, Rafael, Baldisserotto, Bernardo, Pavanato, Maria A.

“…The growth, metabolic and blood parameters and oxidative stress biomarkers effects of adding Lippia alba essential oil (EO) to the diet (0=control, 0.25, 0.5,…”
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Quantification of HDAC inhibition by F-SAHA in rhesus monkey brain using the PET tracer [ 18F]FAHA by Sanabria, Sandra M., Fan, H., Riffel, K., Williams, M., Ryan, C., Gibson, R., Gelovani, J., Cook, J., Hostetler, E.

“…Introduction Central HDAC (histone deacetylases) inhibitors have been proposed as potential novel treatments for a variety of neurodegenerative and cognitive…”
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CYP2D6 Haplotype Determination Using Long Range Allele-Specific Amplification by Gaedigk, Andrea, Riffel, Amanda K, Leeder, J. Steven

“…Cytochrome P450 (CYP) 2D6, a major contributor to the metabolism and bioactivation of many clinically used drugs, is encoded by a complex, highly polymorphic…”
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Moderate hypoxia is able to minimize the manganese-induced toxicity in tissues of silver catfish (Rhamdia quelen) by Dolci, G.S., Dias, V.T., Roversi, K., Roversi, Kr, Pase, C.S., Segat, H.J., Teixeira, A.M., Benvegnú, D.M., Trevizol, F., Barcelos, R.C.S., Riffel, A.P.K., Nunes, M.A.G., Dressler, V.L., Flores, E.M.M., Baldisserotto, B., Bürger, M.E.

“…The aim of this study was to compare the effects of manganese (Mn) on silver catfish exposed to different levels of dissolved oxygen. Silver catfish (Rhamdia…”
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Histamine H3 inverse agonist PET tracers labelled with carbon-11 or fluorine-18 by Hamill, Terence G., Sato, N., Jitsuoka, M., Tokita, S., Krause, S., Ryan, C., Gantert, L., Sleph, H., Zeng, Z., Miller, P., Patel, S., Riffel, K., Sanabria, S., Eng, W., Chen, T., Renger, J.J., Doran, S., Garson, S., Iannone, R., Hargreaves, R., Burns, H.D.

“…Introduction The histamine H3 receptor is a presynaptic autoreceptor in the CNS that regulates the synthesis and release of histamine and also inhibits the…”
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SNP genotyping using TaqMan® technology: the CYP2D617 assay conundrum by Gaedigk, Andrea, Freeman, Natalie, Hartshorne, Toinette, Riffel, Amanda K., Irwin, David, Bishop, Jeffrey R., Stein, Mark A., Newcorn, Jeffrey H., Jaime, Lazara Karelia Montané, Cherner, Mariana, Leeder, J. Steven

“…CYP2D6 contributes to the metabolism of many clinically used drugs and is increasingly tested to individualize drug therapy. The CYP2D6 gene is challenging to…”
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Characterization of a complex CYP2D6 genotype that caused an AmpliChip CYP450 Test no-call in the clinical setting by Gaedigk, Andrea, Riffel, Amanda K, Berrocal, Belén García, Solaesa, Virginia García, Dávila, Ignacio, Isidoro-García, María

“…CYP2D6, a major drug-metabolizing enzyme, is encoded by a highly polymorphic and complex gene locus. We have identified a patient who failed to produce a…”
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Bioequivalence of an ezetimibe/simvastatin combination tablet and coadministration of ezetimibe and simvastatin as separate tablets in healthy subjects by Migoya, E M, Bergman, A, Hreniuk, D, Matthews, N, Yi, B, Roadcap, B, Valesky, R, Liu, L, Riffel, K, Groff, M, Zhao, J J, Musson, D G, Gambale, J, Kosoglou, T, Statkevich, P, Lasseter, K C, Laurent, A, Johnson-Levonas, A O, Murphy, G, Gottesdiener, K, Paolini, J F

“…To assess the bioequivalence of an ezetimibe/simvastatin (EZE/SIMVA) combination tablet compared to the coadministration of ezetimibe and simvastatin as…”
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Detecting gene expression in buccal mucosa in subjects with asthma versus subjects without asthma by Vyhlidal, Carrie A., Riffel, Amanda K., Dai, Hongying, Rosenwasser, Lanny J., Jones, Bridgette L.

“…Background Differences in mRNA expression for inflammatory markers have been observed between subjects with asthma vs. controls and in relation to…”
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