Search Results - "Rienzo, Matthew"

Reversible covalent direct thrombin inhibitors by Sivaraja, Mohanram, Pozzi, Nicola, Rienzo, Matthew, Lin, Kenneth, Shiau, Timothy P, Clemens, Daniel M, Igoudin, Lev, Zalicki, Piotr, Chang, Stephanie S, Estiarte, M Angels, Short, Kevin M, Williams, David C, Datta, Anirban, Di Cera, Enrico, Kita, David B

“…In recent years, the traditional treatments for thrombotic diseases, heparin and warfarin, are increasingly being replaced by novel oral anticoagulants…”
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Enantioselective Total Synthesis of (+)-Reserpine by Rajapaksa, Naomi S, McGowan, Meredeth A, Rienzo, Matthew, Jacobsen, Eric N

“…A catalytic, enantioselective synthesis of (+)-reserpine is reported. The route features a highly diastereoselective, chiral catalyst-controlled formal…”
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High-throughput screening for high-efficiency small-molecule biosynthesis by Rienzo, Matthew, Jackson, Shaina J., Chao, Lawrence K., Leaf, Timothy, Schmidt, Thomas J., Navidi, Adam H., Nadler, Dana C., Ohler, Maud, Leavell, Michael D.

“…Systems metabolic engineering faces the formidable task of rewiring microbial metabolism to cost-effectively generate high-value molecules from a variety of…”
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Insights into Gating Motions of GLIC via Perturbation of Critical Prolines with Non-Canonical Amino Acid Probes by Rienzo, Matthew, Rocchi, Angela R., Threatt, Stephanie D., Dougherty, Dennis A., Lummis, Sarah C.R.

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Perturbation of Critical Prolines in Gloeobacter violaceus Ligand-gated Ion Channel (GLIC) Supports Conserved Gating Motions among Cys-loop Receptors by Rienzo, Matthew, Rocchi, Angela R., Threatt, Stephanie D., Dougherty, Dennis A., Lummis, Sarah C.R.

“…Gloeobacter violaceus ligand-gated ion channel (GLIC) has served as a valuable structural and functional model for the eukaryotic Cys-loop receptor…”
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Non-canonical Amino Acids as Biochemical Probes of Ligand-Gated Ion Channel Structure and Function by Rienzo, Matthew

“…This dissertation describes several different chemical-scale studies of proteins involved in cellular signaling. The primary focus of this work is on…”
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VE-1902—A direct thrombin inhibitor with reversible covalent mechanism of action shows efficacy with reduced bleeding in rodent models of thrombosis by Sivaraja, Mohanram, Clemens, Daniel M., Sizikov, Sivan, Dash, Subhadra, Xu, Chengpei, Rienzo, Matthew, Yang, Bo, Ryan, Molly, Chattopadhyay, Madhuri, Igoudin, Lev, Chang, Stephanie S., Keutzer, Samuel, Zalicki, Piotr, Estiarte, M. Angels, Shiau, Timothy P., Short, Kevin M., Williams, David C., Datta, Anirban, Pozzi, Nicola, Di Cera, Enrico, Gibson, C. Michael, Fox, Keith A.A., Kita, David B.

“…High incidence of bleeding events remains a key risk for patients taking anticoagulants, especially those in need of long-term combination therapy with…”
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Prokaryotic Cys-Loop Receptor Homologs as Mechanistic Models for Channel Function by Rienzo, Matthew, Shafaat, Oliver S., Gray, Harry B., Lummis, Sarah C.R., Dougherty, Dennis A.

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Structural Requirements in the Transmembrane Domain of GLIC Revealed by Incorporation of Noncanonical Histidine Analogs by Rienzo, Matthew, Lummis, Sarah C.R., Dougherty, Dennis A.

“…The cyanobacterial pentameric ligand-gated ion channel GLIC, a homolog of the Cys-loop receptor superfamily, has provided useful structural and functional…”
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