Search Results - "Rienhoff, Hugh"

The use of appropriate calibration curves corrects for systematic differences in liver R2 values measured using different software packages by Meloni, Antonella, Rienhoff, Hugh Y., Jones, Amber, Pepe, Alessia, Lombardi, Massimo, Wood, John C.

Get full text

Inhibition of LSD1 with Bomedemstat Sensitizes Small Cell Lung Cancer to Immune Checkpoint Blockade and T-Cell Killing by Hiatt, Joseph B, Sandborg, Holly, Garrison, Sarah M, Arnold, Henry U, Liao, Sheng-You, Norton, Justin P, Friesen, Travis J, Wu, Feinan, Sutherland, Kate D, Rienhoff, Hugh Y, Martins, Renato, Houghton, A McGarry, Srivastava, Shivani, MacPherson, David

“…The addition of immune checkpoint blockade (ICB) to platinum/etoposide chemotherapy changed the standard of care for small cell lung cancer (SCLC) treatment…”
Get full text

LSD1 inhibition exerts its antileukemic effect by recommissioning PU.1- and C/EBPα-dependent enhancers in AML by Cusan, Monica, Cai, Sheng F., Mohammad, Helai P., Krivtsov, Andrei, Chramiec, Alan, Loizou, Evangelia, Witkin, Matthew D., Smitheman, Kimberly N., Tenen, Daniel G., Ye, Min, Will, Britta, Steidl, Ulrich, Kruger, Ryan G., Levine, Ross L., Rienhoff, Hugh Y., Koche, Richard P., Armstrong, Scott A.

“…Epigenetic regulators are recurrently mutated and aberrantly expressed in acute myeloid leukemia (AML). Targeted therapies designed to inhibit these…”
Get full text

Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models by Jasmine, Sumer, Mandl, Adel, Krueger, Timothy E. G., Dalrymple, Susan L., Antony, Lizamma, Dias, Jennifer, Celatka, Cassandra A., Tapper, Amy E., Kleppe, Maria, Kanayama, Mayuko, Jing, Yuezhou, Speranzini, Valentina, Wang, Yuzhuo Z., Luo, Jun, Trock, Bruce J., Denmeade, Samuel R., Carducci, Michael A., Mattevi, Andrea, Rienhoff, Hugh Y., Isaacs, John T., Brennen, W. Nathaniel

“…Introduction Lysine‐specific demethylase 1 (LSD1) is emerging as a critical mediator of tumor progression in metastatic castration‐resistant prostate cancer…”
Get full text

Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia by Jiang, Qu, Stachelscheid, Johanna, Bloehdorn, Johannes, Pacholewska, Alicja, Aszyk, Christoph, Grotenhuijs, Francien, Müller, Tony, Onder, Ozlem, Wagle, Prerana, Herling, Carmen D., Kleppe, Maria, Wang, Zhefang, Coombes, Kevin R., Robrecht, Sandra, Dalvi, Priya S., Plosnita, Bianca, Mayer, Petra, Abruzzo, Lynne V., Altmüller, Janine, Gathof, Birgit, Persigehl, Thorsten, Fischer, Kirsten, Jebaraj, Billy, Rienhoff, Hugh Y., Ecker, Rupert, Zhao, Yue, Bruns, Christiane J., Stilgenbauer, Stephan, Elenitoba-Johnson, Kojo, Hallek, Michael, Schweiger, Michal R., Odenthal, Margarete, Vasyutina, Elena, Herling, Marco

“…•KDM1A activation marks high-risk CLL, and genetic KDM1A depletion impedes leukemic growth via cell-intrinsic and milieu-derived programs.•KDM1A loss alters H3…”
Get full text

LSD1 Inhibition Prolongs Survival in Mouse Models of MPN by Selectively Targeting the Disease Clone by Jutzi, Jonas S., Kleppe, Maria, Dias, Jennifer, Staehle, Hans Felix, Shank, Kaitlyn, Teruya‐Feldstein, Julie, Gambheer, Sudheer Madan Mohan, Dierks, Christine, Rienhoff, Hugh Y., Levine, Ross L., Pahl, Heike L.

“…Supplemental Digital Content is available in the text Despite recent advances, the myeloproliferative neoplasms (MPNs) are attended by considerable morbidity…”
Get full text

Antimalarial iron chelator, FBS0701, shows asexual and gametocyte Plasmodium falciparum activity and single oral dose cure in a murine malaria model by Ferrer, Patricia, Tripathi, Abhai K, Clark, Martha A, Hand, Carla Cerami, Rienhoff, Jr, Hugh Young, Sullivan, Jr, David J

“…Iron chelators for the treatment of malaria have proven therapeutic activity in vitro and in vivo in both humans and mice, but their clinical use is limited by…”
Get full text

A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with marfan and loeys-dietz syndrome by Rienhoff Jr, Hugh Young, Yeo, Chang-Yeol, Morissette, Rachel, Khrebtukova, Irina, Melnick, Jonathan, Luo, Shujun, Leng, Nan, Kim, Yeon-Jin, Schroth, Gary, Westwick, John, Vogel, Hannes, McDonnell, Nazli, Hall, Judith G., Whitman, Malcolm

“…The transforming growth factor β (TGF‐β) family of growth factors are key regulators of mammalian development and their dysregulation is implicated in human…”
Get full text

Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes by Padalino, Gilda, Celatka, Cassandra A, Rienhoff, Jr, Hugh Y, Kalin, Jay H, Cole, Philip A, Lassalle, Damien, Forde-Thomas, Josephine, Chalmers, Iain W, Brancale, Andrea, Grunau, Christoph, Hoffmann, Karl F

“…: , a parasitic worm species responsible for the neglected tropical disease schistosomiasis, undergoes strict developmental regulation of gene expression that…”
Get full text

A phase 2 study of the safety, tolerability, and pharmacodynamics of FBS0701, a novel oral iron chelator, in transfusional iron overload by Neufeld, Ellis J., Galanello, Renzo, Viprakasit, Vip, Aydinok, Yesim, Piga, Antonio, Harmatz, Paul, Forni, Gian Luca, Shah, Farrukh T., Grace, Rachael F., Porter, John B., Wood, John C., Peppe, Jennifer, Jones, Amber, Rienhoff, Hugh Young

“…This was a 24-week, multicenter phase- 2 study designed to assess safety, tolerability, and pharmacodynamics of FBS0701, a novel oral chelator, in adults with…”
Get full text

A phase 1 dose-escalation study: safety, tolerability, and pharmacokinetics of FBS0701, a novel oral iron chelator for the treatment of transfusional iron overload by Hugh Young Rienhoff, Jr, Vip Viprakasit, Lay Tay, Paul Harmatz, Elliott Vichinsky, Deborah Chirnomas, Janet L. Kwiatkowski, Amy Tapper, William Kramer, John B. Porter, Ellis J. Neufeld

“…There is still a clinical need for a well-tolerated and safe iron chelator for the treatment of transfusional iron overload. We describe the pharmacokinetic…”
Get full text

Cardiac R2 values are independent of the image analysis approach employed by Meloni, Antonella, Rienhoff Jr, Hugh Young, Jones, Amber, Pepe, Alessia, Lombardi, Massimo, Wood, John C.

“…Purpose To determine whether systematic differences were present between myocardial R2* values obtained with two different decay models: truncation and…”
Get full text

Response to "De novo mutation of the TGFB3 latency-associated peptide domain in a patient with overgrowth and Loeys-Dietz syndrome features" by Rienhoff Jr, Hugh Young

Get full text

Two monogenic disorders masquerading as one: severe congenital neutropenia with monocytosis and non-syndromic sensorineural hearing loss by Venugopal, Parvathy, Gagliardi, Lucia, Forsyth, Cecily, Feng, Jinghua, Phillips, Kerry, Babic, Milena, Poplawski, Nicola K, Rienhoff, Jr, Hugh Young, Schreiber, Andreas W, Hahn, Christopher N, Brown, Anna L, Scott, Hamish S

“…We report a large family with four successive generations, presenting with a complex phenotype of severe congenital neutropenia (SCN), partially penetrant…”
Get full text

A Phase 2 Study of the LSD1 Inhibitor Img-7289 (bomedemstat) for the Treatment of Essential Thrombocythemia (ET) by Palandri, Francesca, Vianelli, Nicola, Ross, David M, Cochrane, Tara, Lane, Steven W, Larsen, Stephen R, Gerds, Aaron T., Halpern, Anna B., Shortt, Jake, Rossetti, James M., Pettit, Kristen M., Jones, Amber, Peppe, Jennifer, Natsoulis, Georges, Navarro, Willis, Hong, Wan-Jen, Stevenson, William S., Harrison, Claire N., Talpaz, Moshe, Rienhoff, Hugh Young

“…▪ Many patients with ET are resistant to or intolerant of current standards of care (SOC) - hydroxyurea (HU), interferon, anagrelide - underscoring the need…”
Get full text

Are cardiac R2 values dependent on the image analysis approach employed? by Meloni, Antonella, Rienhoff, Hugh Y, Jones, Amber, Pepe, Alessia, Lombardi, Massimo, Wood, John C

“…Doc number: P76…”
Get full text

Reflections on my daughter's DNA by Rienhoff, Hugh Young

Get full text

Genomewide Association Studies and Assessment of Risk of Disease by Pandey, Janardan P, Rienhoff, Hugh Young, Manolio, Teri A

“…To the Editor: In her review of genomewide association studies, Manolio (July 8 issue) 1 states that “An estimated 10 million common SNPs [single-nucleotide…”
Get full text

Iron-Overload–Related Disease in HFE Hereditary Hemochromatosis by Waalen, Jill, Beutler, Ernest

“…To the Editor: The report by Allen et al. (Jan. 17 issue) 1 on iron-overload–related disease in patients with HFE hereditary hemochromatosis states that among…”
Get full text

Single oral dose cure of lethal P. yoelii with a new iron chelator in human clinical trials for iron overload by Tripathi, Abhai, Rienhoff, Hugh, Sullivan, David

“…Background Iron chelators for the treatment of malaria have proven therapeutic activity in vitro and in vivo in both humans and mice, but their clinical use…”
Get full text