Search Results - "Riemke, Pia"
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Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
Published in Nature neuroscience (01-03-2013)“…This study describes the transcriptional programming of yolk sac–derived microglia specification in the brain, in which c-kit–positive erythromyeloid cells are…”
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2
Macrophage development from HSCs requires PU.1-coordinated microRNA expression
Published in Blood (25-08-2011)“…The differentiation of HSCs into myeloid lineages requires the transcription factor PU.1. Whereas PU.1-dependent induction of myeloid-specific target genes has…”
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Journal Article -
3
PU.1 Level-Directed Chromatin Structure Remodeling at the Irf8 Gene Drives Dendritic Cell Commitment
Published in Cell reports (Cambridge) (30-05-2013)“…Dendritic cells (DCs) are essential regulators of immune responses; however, transcriptional mechanisms that establish DC lineage commitment are poorly…”
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Increased DNA methylation of Dnmt3b targets impairs leukemogenesis
Published in Blood (24-03-2016)“…The de novo DNA methyltransferases Dnmt3a and Dnmt3b are of crucial importance in hematopoietic stem cells. Dnmt3b has recently been shown to play a role in…”
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5
Myeloid leukemia with transdifferentiation plasticity developing from T-cell progenitors
Published in The EMBO journal (15-11-2016)“…Unfavorable patient survival coincides with lineage plasticity observed in human acute leukemias. These cases are assumed to arise from hematopoietic stem…”
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