Search Results - "Riemann, Anne"

The Role of microRNAs in Gene Expression and Signaling Response of Tumor Cells to an Acidic Environment by Riemann, Anne, Rauschner, Mandy, Reime, Sarah, Thews, Oliver

“…Many tumors are characterized by marked extracellular acidosis due to increased glycolytic metabolism, which affects gene expression and thereby tumor…”
Get full text

Extracellular Acidosis Modulates the Expression of Epithelial-Mesenchymal Transition (EMT) Markers and Adhesion of Epithelial and Tumor Cells by Riemann, Anne, Rauschner, Mandy, Gießelmann, Marina, Reime, Sarah, Haupt, Verena, Thews, Oliver

“…Epithelial-to-mesenchymal transition (EMT) is an important process of tumor progression associated with increased metastatic potential. EMT can be activated by…”
Get full text

Tumor Acidosis and Hypoxia Differently Modulate the Inflammatory Program: Measurements In Vitro and In Vivo by Riemann, Anne, Reime, Sarah, Thews, Oliver

“…Inflammatory mediators produced by the tumor cells are of importance for immune response but also for malignant progression. The aim of the study was to…”
Get full text

Acidosis differently modulates the inflammatory program in monocytes and macrophages by Riemann, Anne, Wußling, Hanna, Loppnow, Harald, Fu, Hang, Reime, Sarah, Thews, Oliver

“…Inflammation, ischemia or the microenvironment of solid tumors is often accompanied by a reduction of extracellular pH (acidosis) that stresses the cells and…”
Get full text

Acidic environment leads to ROS-induced MAPK signaling in cancer cells by Riemann, Anne, Schneider, Bettina, Ihling, Angelika, Nowak, Martin, Sauvant, Christoph, Thews, Oliver, Gekle, Michael

“…Tumor micromilieu often shows pronounced acidosis forcing cells to adapt their phenotype towards enhanced tumorigenesis induced by altered cellular signalling…”
Get full text

Impact of the acidic environment on gene expression and functional parameters of tumors in vitro and in vivo by Rauschner, Mandy, Lange, Luisa, Hüsing, Thea, Reime, Sarah, Nolze, Alexander, Maschek, Marcel, Thews, Oliver, Riemann, Anne

“…The low extracellular pH (pH ) of tumors resulting from glycolytic metabolism is a stress factor for the cells independent from concomitant hypoxia. The aim of…”
Get full text

Role of acidosis-sensitive microRNAs in gene expression and functional parameters of tumors in vitro and in vivo by Rauschner, Mandy, Hüsing, Thea, Lange, Luisa, Jarosik, Kristin, Reime, Sarah, Riemann, Anne, Thews, Oliver

“…Background: The acidic extracellular environment of tumors has been shown to affect the malignant progression of tumor cells by modulating proliferation, cell…”
Get full text

Correlation between Circulating miR-16, miR-29a, miR-144 and miR-150, and the Radiotherapy Response and Survival of Non-Small-Cell Lung Cancer Patients by Bache, Matthias, Kadler, Frauke, Struck, Olivia, Medenwald, Daniel, Ostheimer, Christian, Güttler, Antje, Keßler, Jacqueline, Kappler, Matthias, Riemann, Anne, Thews, Oliver, Seliger, Barbara, Vordermark, Dirk

“…Despite the success of current therapy concepts, patients with advanced non-small-cell lung cancer (NSCLC) still have a very poor prognosis. Therefore,…”
Get full text

Acidosis induces multi‐drug resistance in rat prostate cancer cells (AT1) in vitro and in vivo by increasing the activity of the p‐glycoprotein via activation of p38 by Sauvant, Christoph, Nowak, Martin, Wirth, Claudia, Schneider, Bettina, Riemann, Anne, Gekle, Michael, Thews, Oliver

“…Because solid growing tumors often show hypoxia and pronounced extracellular acidosis, the aim of this study was to analyze the impact of an acidotic…”
Get full text

Causes and Consequences of A Glutamine Induced Normoxic HIF1 Activity for the Tumor Metabolism by Kappler, Matthias, Pabst, Ulrike, Weinholdt, Claus, Taubert, Helge, Rot, Swetlana, Kaune, Tom, Kotrba, Johanna, Porsch, Martin, Güttler, Antje, Bache, Matthias, Krohn, Knut, Bull, Fabian, Riemann, Anne, Wickenhauser, Claudia, Seliger, Barbara, Schubert, Johannes, Al-Nawas, Bilal, Thews, Oliver, Grosse, Ivo, Vordermark, Dirk, Eckert, Alexander W

“…The transcription factor hypoxia-inducible factor 1 (HIF1) is the crucial regulator of genes that are involved in metabolism under hypoxic conditions, but…”
Get full text

Impact of extracellular acidosis on intracellular pH control and cell signaling in tumor cells by Riemann, Anne, Ihling, Angelika, Schneider, Bettina, Gekle, Michael, Thews, Oliver

“…Cells in solid tumors generate an extracellular acidosis due to the Warburg effect and tissue hypoxia. Acidosis can affect the functional behavior of tumor…”
Get more information

Tumor pH and metastasis: a malignant process beyond hypoxia by Thews, Oliver, Riemann, Anne

“…Tumors often show, compared to normal tissues, a markedly decreased extracellular pH resulting from anaerobic or aerobic glycolysis in combination with a…”
Get full text

Acidic priming enhances metastatic potential of cancer cells by Riemann, Anne, Schneider, Bettina, Gündel, Daniel, Stock, Christian, Thews, Oliver, Gekle, Michael

Get full text

Correction to: Tumor pH and metastasis: a malignant process beyond hypoxia by Thews, Oliver, Riemann, Anne

“…The authors have noticed a typographical error in the published article. The term “epithelial-to-mesenchymal transition” should have been used instead of the…”
Get full text

Acidic extracellular environment affects miRNA expression in tumors in vitro and in vivo by Riemann, Anne, Reime, Sarah, Thews, Oliver

“…Hypoxia can control the expression of miRNAs in tumors which play an important role for the control of the malignant behavior. The aim of the study was to…”
Get full text

Acidic priming enhances metastatic potential of cancer cells by Riemann, Anne, Schneider, Bettina, Gündel, Daniel, Stock, Christian, Thews, Oliver, Gekle, Michael

“…Metabolic acidosis is a common feature of tumor microenvironment and may affect the phenotype of tumor cells, including invasive capacity and formation of…”
Get full text

Cellular and radiobiological effects of carbonic anhydrase IX in human breast cancer cells by Güttler, Antje, Theuerkorn, Katharina, Riemann, Anne, Wichmann, Henri, Kessler, Jacqueline, Thews, Oliver, Bache, Matthias, Vordermark, Dirk

“…Hypoxia‑induced carbonic anhydrase IX (CAIX) is involved in intracellular and extracellular pH regulation, which is critical for tumor growth and metastasis…”
Get full text

Functional Impact of Acidosis-Regulated MicroRNAs on the Migration and Adhesion of Tumor Cells by Hüsing, T, Lange, L, Rauschner, M, Riemann, Anne, Thews, O

“…Tumor tissue shows special features in metabolism in contrast to healthy tissue. Besides a distinctive oxygen deficiency, tumors often show a reduced…”
Get more information

The Acidic Tumor Microenvironment Affects Epithelial-Mesenchymal Transition Markers as Well as Adhesion of NCI-H358 Lung Cancer Cells by Riemann, Anne, Rauschner, M, Gießelmann, M, Reime, S, Thews, O

“…Epithelial-mesenchymal transition (EMT), which is involved in metastasis formation, requires reprogramming of gene expression mediated by key EMT transcription…”
Get more information

The Role of MicroRNA Expression for Proliferation and Apoptosis of Tumor Cells: Impact of Hypoxia-Related Acidosis by Lange, L, Hüsing, T, Rauschner, M, Riemann, Anne, Thews, O

“…The metabolic microenvironment in tumors is characterized by hypoxia and acidosis. Extracellular pH sometimes decreases to even below 6.0. Previous experiments…”
Get more information