Search Results - "Riel, Jonathan M"

Two Y Genes Can Replace the Entire Y Chromosome for Assisted Reproduction in the Mouse by Yamauchi, Yasuhiro, Riel, Jonathan M., Stoytcheva, Zoia, Ward, Monika A.

“…The Y chromosome is thought to be important for male reproduction. We have previously shown that with the use of assisted reproduction, live offspring can be…”
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Mouse Y-Encoded Transcription Factor Zfy2 Is Essential for Sperm Formation and Function in Assisted Fertilization by Yamauchi, Yasuhiro, Riel, Jonathan M, Ruthig, Victor, Ward, Monika A

“…Spermatogenesis is a key developmental process allowing for a formation of a mature male gamete. During its final phase, spermiogenesis, haploid round…”
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Two genes substitute for the mouse Y chromosome for spermatogenesis and reproduction by Yamauchi, Yasuhiro, Riel, Jonathan M., Ruthig, Victor A., Ortega, Eglė A., Mitchell, Michael J., Ward, Monika A.

“…The mammalian Y chromosome is considered a symbol of maleness, as it encodes a gene driving male sex determination, Sry, as well as a battery of other genes…”
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Deficiency of the multi-copy mouse Y gene Sly causes sperm DNA damage and abnormal chromatin packaging by Riel, Jonathan M, Yamauchi, Yasuhiro, Sugawara, Atsushi, Li, Ho Yan J, Ruthig, Victor, Stoytcheva, Zoia, Ellis, Peter J I, Cocquet, Julie, Ward, Monika A

“…In mouse and man Y chromosome deletions are frequently associated with spermatogenic defects. Mice with extensive deletions of non-pairing Y chromosome long…”
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Live Offspring from Mice Lacking the Y Chromosome Long Arm Gene Complement by Yamauchi, Yasuhiro, Riel, Jonathan M, Wong, Samantha J, Ojarikre, Obah A, Burgoyne, Paul S, Ward, Monika A

“…The mouse Y chromosome long arm (Yq) comprises ~70 Mb of repetitive, male-specific DNA together with a short (0.7-Mb) pseudoautosomal region (PAR). The…”
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Ejaculated and Epididymal Mouse Spermatozoa Are Different in Their Susceptibility to Nuclease-Dependent DNA Damage and in Their Nuclease Activity by Yamauchi, Yasuhiro, Ajduk, Anna, Riel, Jonathan M, Ward, Monika A

“…Ejaculated mouse sperm retrieved from the uteri are more susceptible to DNA damage during freeze-drying and freezing without cryoprotection than epididymal…”
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Pregnancy environment, and not preconception, leads to fetal growth restriction and congenital abnormalities associated with diabetes by Tsai, Pai-Jong Stacy, Yamauchi, Yasuhiro, Riel, Jonathan M., Ward, Monika A.

“…Maternal diabetes can lead to pregnancy complications and impaired fetal development. The goal of this study was to use a mouse model of reciprocal embryo…”
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Live Offspring from Mice Lacking the Y Chromosome Long Arm Gene Complement1 by Yamauchi, Yasuhiro, Riel, Jonathan M, Wong, Samantha J, Ojarikre, Obah A, Burgoyne, Paul S, Ward, Monika A

“…The mouse Y chromosome long arm (Yq) comprises ∼70 Mb of repetitive, male-specific DNA together with a short (0.7-Mb) pseudoautosomal region (PAR). The…”
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Testicular abnormalities in mice with Y chromosome deficiencies by Ruthig, Victor A, Nielsen, Torbjoern, Riel, Jonathan M, Yamauchi, Yasuhiro, Ortega, Egle˙ A, Salvador, Quinci, Ward, Monika A

“…We recently investigated mice with Y chromosome gene contribution limited to two, one, or no Y chromosome genes in respect to their ability to produce haploid…”
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Deficiency in mouse Y chromosome long arm gene complement is associated with sperm DNA damage by Yamauchi, Yasuhiro, Riel, Jonathan M, Stoytcheva, Zoia, Burgoyne, Paul S, Ward, Monika A

“…Mice with severe non-PAR Y chromosome long arm (NPYq) deficiencies are infertile in vivo and in vitro. We have previously shown that sperm from these males,…”
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Rescue of Sly Expression Is Not Sufficient to Rescue Spermiogenic Phenotype of Mice with Deletions of Y Chromosome Long Arm by Riel, Jonathan M, Yamauchi, Yasuhiro, Ruthig, Victor A, Malinta, Qushay U, Blanco, Mélina, Moretti, Charlotte, Cocquet, Julie, Ward, Monika A

“…Mice with deletions of the Y-specific (non-PAR) region of the mouse Y chromosome long arm (NPYq) have sperm defects and fertility problems that increase…”
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Deficiency in the multicopy Sycp3-like X-linked genes Slx and Slxl1 causes major defects in spermatid differentiation by Cocquet, Julie, Ellis, Peter J I, Yamauchi, Yasuhiro, Riel, Jonathan M, Karacs, Thomas P S, Rattigan, Aine, Ojarikre, Obah A, Affara, Nabeel A, Ward, Monika A, Burgoyne, Paul S

“…The human and mouse sex chromosomes are enriched in multicopy genes required for postmeiotic differentiation of round spermatids into sperm. The gene Sly is…”
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Freezing-Free Preservation of Human Spermatozoa - A Pilot Study by Riel, Jonathan M., Huang, Thomas T. F., Ward, Monika A.

“…This study tested a method for maintaining human spermatozoa without freezing for subsequent use in intracytoplasmic sperm injection (ICSI). We demonstrated…”
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Paternal DNA Damage Resulting From Various Sperm Treatments Persists After Fertilization and Is Similar Before and After DNA Replication by Yamauchi, Yasuhiro, Riel, Jonathan M., Ward, Monika A.

“…In spite of its highly condensed state, sperm DNA is vulnerable to damage that can originate from oxidative stress, the activity of sperm‐specific nucleases,…”
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Short-Term Storage of Human Spermatozoa in Electrolyte-Free Medium Without Freezing Maintains Sperm Chromatin Integrity Better Than Cryopreservation by RIEL, Jonathan M, YAMAUCHI, Yasuhiro, HUANG, Thomas T. F, GROVE, John, WARD, Monika A

“…Previous attempts to maintain human spermatozoa without freezing were based on short-term storage in component-rich medium and led to fast decline in motility…”
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Short-Term Storage of Human Spermatozoa in Electrolyte-Free Medium Without Freezing Maintains Sperm Chromatin Integrity Better Than Cryopreservation1 by Riel, Jonathan M, Yamauchi, Yasuhiro, Huang, Thomas T.F, Grove, John, Ward, Monika A

“…Previous attempts to maintain human spermatozoa without freezing were based on short-term storage in component-rich medium and led to fast decline in motility…”
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Ejaculated and Epididymal Mouse Spermatozoa Are Different in Their Susceptibility to Nuclease-Dependent DNA Damage and in Their Nuclease Activity1 by Yamauchi, Yasuhiro, Ajduk, Anna, Riel, Jonathan M, Ward, Monika A

“…Ejaculated mouse sperm retrieved from the uteri are more susceptible to DNA damage during freeze-drying and freezing without cryoprotection than epididymal…”
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Mouse Y-Encoded Transcription Factor Zfy2 Is Essential for Sperm Formation and Function in Assisted Fertilization: e1005476 by Yamauchi, Yasuhiro, Riel, Jonathan M, Ruthig, Victor, Ward, Monika A

“…Spermatogenesis is a key developmental process allowing for a formation of a mature male gamete. During its final phase, spermiogenesis, haploid round…”
Get full text

Two genes substitute for the mouse Y chromosome for spermatogenesis andă reproduction by Yamauchi, Yasuhiro, Riel, Jonathan M., Ruthig, Egle A., Mitchell, Michael J., Ward, Monika A.

“…The mammalian Y chromosome is considered a symbol of maleness, as ită encodes a gene driving male sex determination, Sry, as well as a batteryă of other genes…”
Get full text

RNAi-Mediated Disruption of the Function of the Multi-Copy Mouse Y Gene Sly Leads to Sperm DNA Damage and Abnormal Chromatin Packaging by Riel, Jonathan M., Yamauchi, Yasuhiro, Li, Ho Yan J., Cocquet, Julie, Burgoyne, Paul, Ward, Monika A.

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