Search Results - "Riekkinen, P.J."

MRI of the Hippocampus in Alzheimer’s Disease: Sensitivity, Specificity, and Analysis of the Incorrectly Classified Subjects by Laakso, M.P, Soininen, H, Partanen, K, Lehtovirta, M, Hallikainen, M, Hänninen, T, Helkala, E.-L, Vainio, P, Riekkinen, P.J

“…In this study, magnetic resonance imaging (MRI) of the hippocampus for the diagnosis of early Alzheimer’s disease (AD) is evaluated. We measured hippocampal…”
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Loss of synaptophysin-like immunoreactivity in the hippocampal formation is an early phenomenon in alzheimer's disease by Heinonen, O., Soininen, H., Sorvari, H., Kosunen, O., Palja¨rvi, L., Koivisto, E., Riekkinen, P.J.

“…We studied a synaptophysin-like immunoreactivity in the hippocampal formation of patients with definite Alzheimer's disease, multi-infarct dementia, patients…”
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Relation of coronary atherosclerosis and apolipoprotein E genotypes in Alzheimer patients by Kosunen, O, Talasniemi, S, Lehtovirta, M, Heinonen, O, Helisalmi, S, Mannermaa, A, Paljärvi, L, Ryynänen, M, Riekkinen, Sr, P J, Soininen, H

“…Apolipoprotein E (apoE) epsilon 4 allele has been associated with a high risk for coronary heart disease. Increased frequency of the epsilon 4 allele has also…”
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Decreased muscarinic receptor binding in cerebral cortex and hippocampus in Alzheimer's disease by Reinikainen, K J, Riekkinen, P J, Halonen, T, Laakso, M

“…Muscarinic (cholinergic) receptor binding sites (MRB) were studied by determining the 3H-QNB binding in four cortical areas and hippocampus of 20…”
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Brain cholinergic enzymes and cortical EEG activity in young and old rats by Sirviö, J, Pitkänen, A, Pääkkönen, A, Partanen, J, Riekkinen, P J

“…1. Cholinergic enzymes (ChAT, AChE) in different areas of the brain and cortical electroencephalography (EEG) activity were investigated in young and old rats…”
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Volumes of hippocampus, amygdala and frontal lobe in Alzheimer patients with different apolipoprotein E genotypes by Lehtovirta, M., Laakso, M.P., Soininen, H., Helisalmi, S., Mannermaa, A., Helkala, E.-L., Partanen, K., Ryynänen, M., Vainio, P., Hartikainen, P., Riekkinen, P.J.

“…An increased frequency of apolipoprotein E E4 allele has been reported in patients with late onset Alzheimer's disease. Apolipoprotein E participates in the…”
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Longitudinal EEG spectral analysis in early stage of Alzheimer's disease by Soininen, H, Partanen, J, Laulumaa, V, Helkala, E L, Laakso, M, Riekkinen, P J

“…Twenty-four patients with mild to moderate Alzheimer's disease (AD) were studied using quantitative spectral analysis of EEG at the time of the diagnosis and 1…”
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ApoE and memory in old age by Soininen, H.S., Riekkinen, P.J.

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Quantitative analysis of occipital EEG in different stages of Alzheimer's disease by Penttilä, M, Partanen, J V, Soininen, H, Riekkinen, P J

“…EEG frequency analysis by Fast Fourier Transform (FFT) was studied in different stages of Alzheimer's disease (AD), defined according to the neuropsychological…”
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Pattern of neuronal death in the rat hippocampus after status epilepticus. Relationship to calcium binding protein content and ischemic vulnerability by Freund, T F, Ylinen, A, Miettinen, R, Pitkänen, A, Lahtinen, H, Baimbridge, K G, Riekkinen, P J

“…The pattern of hippocampal cell death has been studied following hippocampal seizure activity and status epilepticus induced by 110-min stimulation of the…”
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Alzheimer pathology of patients carrying apoliprotein E ϵ4 allele by Heinonen, O., Lehtovirta, M., Soininen, H., Helisalmi, S., Mannermaa, A., Sorvari, H., Kosunen, O., Paljärvi, L., Ryynanen, M., Riekkinen, P.J.

“…A recent report suggested that brains of Alzheimer patients homozygous for APOE ϵ4 show increased amyloid pathology compared to APOE ϵ3 homozygotes. We studied…”
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Long-term cognitive and EEG effects of tiagabine in drug-resistant partial epilepsy by Kälviäinen, R., Äikiä, M., Mervaala, E., Saukkonen, A.M., Pitkänen, A., Riekkinen, P.J.

“…A new anti-epileptic drug, tiagabine, is a potent inhibitor of GABA uptake into neurons and glia. Tiagabine has shown promising efficacy and safety profiles as…”
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597 Apolipoprotein E ε4 allele as a risk gene for early changes in temporal lobe structures — MRI volumetric and cognitive changes by Alafuzoff, I.I., Riekkinen, P.J., Soininen, H.S.

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Cognitive effects of oxcarbazepine and phenytoin monotherapy in newly diagnosed epilepsy: one year follow-up by Aikiä, M, Kälviäinen, R, Sivenius, J, Halonen, T, Riekkinen, P J

“…We evaluated the effect of initial oxcarbazepine (OXC) monotherapy on memory, attention and simple psychomotor speed in 14 patients; 15 patients with initial…”
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5-17-12 Hippocampal and amygdalar MRI volumetry and memory scores during vigabatrin monotherapy by Riekkinen, P.J., Kälviäinen, R., Äikiä, M., Partanen, K., Salmenperä, T.

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MR T 2 relaxometry in Alzheimer's disease and age-associated memory impairment by Laakso, M.P., Partanen, K., Soininen, H., Lehtovirta, M., Hallikainen, M., Hänninen, T., Helkala, E.-L., Vainio, P., Riekkinen, P.J.

“…A prolonged MR T 2 relaxation time was proposed to mark the presence and severity of Alzheimer's disease (AD). We studied the value of T 2 relaxometry in…”
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Enhancements of synaptic transmission, LTP and memory by pharmacological agents by Sirviö, J., Pitkänen, M., Pussinen, R., Haapalinna, A., Riekkinen, P.J.

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Slowing of electroencephalogram and choline acetyltransferase activity in post mortem frontal cortex in definite Alzheimer's disease by Soininen, H, Reinikainen, K J, Partanen, J, Helkala, E L, Paljärvi, L, Riekkinen, P J

“…Twenty-five (96%) of 26 patients with histologically verified moderate to severe Alzheimer's disease had abnormal electroencephalograms. The patients with the…”
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540 Cholinergic function and apolipoprotein E polymorphism in Alzheimer's disease by Soininen, H., Lehtovirta, M., Helisalmi, S., Linnaranta, K., Heinonen, O., Kosunen, O., Paljärvi, L., Riekkinen, P.J.

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579 Efficacy and safety of selegiline in the long-term treatment of patients with Alzheimer's disease by Riekkinen, P.J., Koivisto, K., Helkala, E.-L., Hänninen, T., Reinikainen, K.J., Kilkku, O., Heinonen, E.

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