Search Results - "Riekelt H. Houtkooper"

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling by Mouchiroud, Laurent, Houtkooper, Riekelt H., Moullan, Norman, Katsyuba, Elena, Ryu, Dongryeol, Cantó, Carles, Mottis, Adrienne, Jo, Young-Suk, Viswanathan, Mohan, Schoonjans, Kristina, Guarente, Leonard, Auwerx, Johan

“…NAD+ is an important cofactor regulating metabolic homeostasis and a rate-limiting substrate for sirtuin deacylases. We show that NAD+ levels are reduced in…”
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Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease by Smith, Reuben L, Soeters, Maarten R, Wüst, Rob C I, Houtkooper, Riekelt H

“…Abstract The ability to efficiently adapt metabolism by substrate sensing, trafficking, storage, and utilization, dependent on availability and requirement, is…”
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Mitochondrial quality control pathways as determinants of metabolic health by Held, Ntsiki M., Houtkooper, Riekelt H.

“…Mitochondrial function is key for maintaining cellular health, while mitochondrial failure is associated with various pathologies, including inherited…”
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Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research by Moullan, Norman, Mouchiroud, Laurent, Wang, Xu, Ryu, Dongryeol, Williams, Evan G., Mottis, Adrienne, Jovaisaite, Virginija, Frochaux, Michael V., Quiros, Pedro M., Deplancke, Bart, Houtkooper, Riekelt H., Auwerx, Johan

“…In recent years, tetracyclines, such as doxycycline, have become broadly used to control gene expression by virtue of the Tet-on/Tet-off systems. However, the…”
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NAD⁺ metabolism: a therapeutic target for age-related metabolic disease by Mouchiroud, Laurent, Houtkooper, Riekelt H, Auwerx, Johan

“…Nicotinamide adenine dinucleotide (NAD) is a central metabolic cofactor by virtue of its redox capacity, and as such regulates a wealth of metabolic…”
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The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways by Houtkooper, Riekelt H, Cantó, Carles, Wanders, Ronald J, Auwerx, Johan

“…A century after the identification of a coenzymatic activity for NAD+, NAD+ metabolism has come into the spotlight again due to the potential therapeutic…”
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PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation by Bai, Péter, Cantó, Carles, Oudart, Hugues, Brunyánszki, Attila, Cen, Yana, Thomas, Charles, Yamamoto, Hiroyasu, Huber, Aline, Kiss, Borbála, Houtkooper, Riekelt H., Schoonjans, Kristina, Schreiber, Valérie, Sauve, Anthony A., Menissier-de Murcia, Josiane, Auwerx, Johan

“…SIRT1 regulates energy homeostasis by controlling the acetylation status and activity of a number of enzymes and transcriptional regulators. The fact that NAD+…”
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NAD+ homeostasis in human health and disease by Zapata‐Pérez, Rubén, Wanders, Ronald J A, van Karnebeek, Clara D M, Houtkooper, Riekelt H

“…Depletion of nicotinamide adenine dinucleotide (NAD + ), a central redox cofactor and the substrate of key metabolic enzymes, is the causative factor of a…”
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Exploring the therapeutic space around NAD by Houtkooper, Riekelt H, Auwerx, Johan

“…NAD(+) is a central metabolite in the cell. Changes in NAD(+) abundance and the activity of NAD(+)-dependent enzymes, such as the sirtuins, are at the core of…”
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Systems Genetics of Metabolism: The Use of the BXD Murine Reference Panel for Multiscalar Integration of Traits by Andreux, Pénélope A., Williams, Evan G., Koutnikova, Hana, Houtkooper, Riekelt H., Champy, Marie-France, Henry, Hugues, Schoonjans, Kristina, Williams, Robert W., Auwerx, Johan

“…Metabolic homeostasis is achieved by complex molecular and cellular networks that differ significantly among individuals and are difficult to model with…”
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Laminar Shear Stress Inhibits Endothelial Cell Metabolism via KLF2-Mediated Repression of PFKFB3 by Doddaballapur, Anuradha, Michalik, Katharina M, Manavski, Yosif, Lucas, Tina, Houtkooper, Riekelt H, You, Xintian, Chen, Wei, Zeiher, Andreas M, Potente, Michael, Dimmeler, Stefanie, Boon, Reinier A

“…OBJECTIVE—Cellular metabolism was recently shown to regulate endothelial cell phenotype profoundly. Whether the atheroprotective biomechanical stimulus…”
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From molecular promise to preclinical results: HDAC inhibitors in the race for healthy aging drugs by McIntyre, Rebecca L, Daniels, Eileen G, Molenaars, Marte, Houtkooper, Riekelt H, Janssens, Georges E

“…Reversing or slowing the aging process brings great promise to treat or prevent age‐related disease, and targeting the hallmarks of aging is a strategy to…”
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Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells by Janiszewska, Michalina, Suvà, Mario L, Riggi, Nicolo, Houtkooper, Riekelt H, Auwerx, Johan, Clément-Schatlo, Virginie, Radovanovic, Ivan, Rheinbay, Esther, Provero, Paolo, Stamenkovic, Ivan

“…Growth of numerous cancer types is believed to be driven by a subpopulation of poorly differentiated cells, often referred to as cancer stem cells (CSCs), that…”
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The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity by Cantó, Carles, Houtkooper, Riekelt H., Pirinen, Eija, Youn, Dou Y., Oosterveer, Maaike H., Cen, Yana, Fernandez-Marcos, Pablo J., Yamamoto, Hiroyasu, Andreux, Pénélope A., Cettour-Rose, Philippe, Gademann, Karl, Rinsch, Chris, Schoonjans, Kristina, Sauve, Anthony A., Auwerx, Johan

“…As NAD+ is a rate-limiting cosubstrate for the sirtuin enzymes, its modulation is emerging as a valuable tool to regulate sirtuin function and, consequently,…”
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A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans by Koopman, Mandy, Michels, Helen, Dancy, Beverley M, Kamble, Rashmi, Mouchiroud, Laurent, Auwerx, Johan, Nollen, Ellen A A, Houtkooper, Riekelt H

“…Mitochondrial dysfunction is linked to a range of common disorders, including inherited metabolic diseases, diabetes and cancer. Here, Koopman et al. describe…”
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Disorders of mitochondrial long-chain fatty acid oxidation and the carnitine shuttle by Knottnerus, Suzan J. G., Bleeker, Jeannette C., Wüst, Rob C. I., Ferdinandusse, Sacha, IJlst, Lodewijk, Wijburg, Frits A., Wanders, Ronald J. A., Visser, Gepke, Houtkooper, Riekelt H.

“…Mitochondrial fatty acid oxidation is an essential pathway for energy production, especially during prolonged fasting and sub-maximal exercise. Long-chain…”
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Atherogenic Lipoprotein(a) Increases Vascular Glycolysis, Thereby Facilitating Inflammation and Leukocyte Extravasation by Schnitzler, Johan G., Hoogeveen, Renate M., Ali, Lubna, Prange, Koen H.M., Waissi, Farahnaz, van Weeghel, Michel, Bachmann, Julian C., Versloot, Miranda, Borrelli, Matthew J., Yeang, Calvin, De Kleijn, Dominique P.V., Houtkooper, Riekelt H., Koschinsky, Marlys L., de Winther, Menno P.J., Groen, Albert K., Witztum, Joseph L., Tsimikas, Sotirios, Stroes, Erik S.G., Kroon, Jeffrey

“…Patients with elevated levels of lipoprotein(a) [Lp(a)] are hallmarked by increased metabolic activity in the arterial wall on positron emission…”
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Tetracycline antibiotics impair mitochondrial function and its experimental use confounds research by Chatzispyrou, Iliana A, Held, Ntsiki M, Mouchiroud, Laurent, Auwerx, Johan, Houtkooper, Riekelt H

“…Tetracyclines, a class of antibiotics that target bacterial translation, are commonly used in research for inducible gene expression using Tet-ON/Tet-OFF…”
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Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans by Timmers, Silvie, Konings, Ellen, Bilet, Lena, Houtkooper, Riekelt H., van de Weijer, Tineke, Goossens, Gijs H., Hoeks, Joris, van der Krieken, Sophie, Ryu, Dongryeol, Kersten, Sander, Moonen-Kornips, Esther, Hesselink, Matthijs K.C., Kunz, Iris, Schrauwen-Hinderling, Vera B., Blaak, Ellen E., Auwerx, Johan, Schrauwen, Patrick

“…Resveratrol is a natural compound that affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal…”
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Mitochondrial response to nutrient availability and its role in metabolic disease by Gao, Arwen W, Cantó, Carles, Houtkooper, Riekelt H

“…Metabolic inflexibility is defined as an impaired capacity to switch between different energy substrates and is a hallmark of insulin resistance and type 2…”
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