Search Results - "Rieg, Timo"

SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice by Vallon, Volker, Gerasimova, Maria, Rose, Michael A, Masuda, Takahiro, Satriano, Joseph, Mayoux, Eric, Koepsell, Hermann, Thomson, Scott C, Rieg, Timo

“…Our previous work has shown that gene knockout of the sodium-glucose cotransporter SGLT2 modestly lowered blood glucose in streptozotocin-diabetic mice (BG;…”
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New functions and roles of the Na+-H+-exchanger NHE3 by Dominguez Rieg, Jessica A., Rieg, Timo

“…The sodium/proton exchanger isoform 3 (NHE3) is expressed in the intestine and the kidney, where it contributes to hydrogen secretion and sodium…”
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Increase in SGLT1-mediated transport explains renal glucose reabsorption during genetic and pharmacological SGLT2 inhibition in euglycemia by Rieg, Timo, Masuda, Takahiro, Gerasimova, Maria, Mayoux, Eric, Platt, Kenneth, Powell, David R, Thomson, Scott C, Koepsell, Hermann, Vallon, Volker

“…In the kidney, the sodium-glucose cotransporters SGLT2 and SGLT1 are thought to account for >90 and ∼3% of fractional glucose reabsorption (FGR), respectively…”
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Acute and chronic effects of SGLT2 blockade on glomerular and tubular function in the early diabetic rat by Thomson, Scott C, Rieg, Timo, Miracle, Cynthia, Mansoury, Hadi, Whaley, Jean, Vallon, Volker, Singh, Prabhleen

“…Tubuloglomerular feedback (TGF) stabilizes nephron function from minute to minute and adapts to different steady-state inputs to maintain this capability. Such…”
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SGLT2 inhibition effect on salt-induced hypertension, RAAS, and Na + transport in Dahl SS rats by Kravtsova, Olha, Bohovyk, Ruslan, Levchenko, Vladislav, Palygin, Oleg, Klemens, Christine A, Rieg, Timo, Staruschenko, Alexander

“…Na -glucose cotransporter-2 (SGLT2) inhibitors are the new mainstay of treatment for diabetes mellitus and cardiovascular diseases. Despite the remarkable…”
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Na+-D-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion by GORBOULEV, Valentin, SCHÜRMANN, Annette, VEYHL-WICHMANN, Maike, SRINIVASAN, Aruna, BALEN, Daniela, BRELJAK, Davorka, REXHEPAJ, Rexhep, PARKER, Helen E, GRIBBLE, Fiona M, REIMANN, Frank, LANG, Florian, WIESE, Stefan, VALLON, Volker, SABOLIC, Ivan, SENDTNER, Michael, KOEPSELL, Hermann, KIPP, Helmut, JASCHKE, Alexander, KLESSEN, Dirk, FRIEDRICH, Alexandra, SCHERNECK, Stephan, RIEG, Timo, CUNARD, Robyn

“…To clarify the physiological role of Na(+)-D-glucose cotransporter SGLT1 in small intestine and kidney, Sglt1(-/-) mice were generated and characterized…”
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Effect of SGLT2 inhibition on salt-induced hypertension in female Dahl SS rats by Kravtsova, Olha, Levchenko, Vladislav, Klemens, Christine A., Rieg, Timo, Liu, Ruisheng, Staruschenko, Alexander

“…Sodium-glucose co-transporters (SGLTs) in the kidneys play a pivotal role in glucose reabsorption. Several clinical and population-based studies revealed the…”
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Rapid Aldosterone-Mediated Signaling in the DCT Increases Activity of the Thiazide-Sensitive NaCl Cotransporter by Cheng, Lei, Poulsen, Søren Brandt, Wu, Qi, Esteva-Font, Cristina, Olesen, Emma T B, Peng, Li, Olde, Björn, Leeb-Lundberg, L M Fredrik, Pisitkun, Trairak, Rieg, Timo, Dimke, Henrik, Fenton, Robert A

“…The NaCl cotransporter NCC in the kidney distal convoluted tubule (DCT) regulates urinary NaCl excretion and BP. Aldosterone increases NaCl reabsorption NCC…”
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Vitamin D3 suppresses Npt2c abundance and differentially modulates phosphate and calcium homeostasis in Npt2a knockout mice by Thomas, Linto, Dissanayake, Lashodya V., Tahmasbi, Maryam, Staruschenko, Alexander, Al-Masri, Sima, Dominguez Rieg, Jessica A., Rieg, Timo

“…Vitamin D 3 is clinically used for the treatment of vitamin D 3 deficiency or osteoporosis, partially because of its role in regulating phosphate (P i ) and…”
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Genetic deletion of connexin 37 causes polyuria and polydipsia by Xue, Jianxiang, Thomas, Linto, Dominguez Rieg, Jessica A, Fenton, Robert A, Rieg, Timo

“…The connexin 37 (Cx37) channel is clustered at gap junctions between cells in the renal vasculature or the renal tubule where it is abundant in basolateral…”
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Novel developments in differentiating the role of renal and intestinal sodium hydrogen exchanger 3 by Dominguez Rieg, Jessica A, de la Mora Chavez, Samantha, Rieg, Timo

“…The Na /H exchanger isoform 3 (NHE3) facilitates Na absorption and H secretion and is expressed in the intestine, proximal tubule, and thick ascending limb of…”
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Epac induces ryanodine receptor-dependent intracellular and inter-organellar calcium mobilization in mpkCCD cells by Yip, Kay-Pong, Ribeiro-Silva, Luisa, Cha, Byeong, Rieg, Timo, Sham, James S. K.

“…Arginine vasopressin (AVP) induces an increase in intracellular Ca 2+ concentration ([Ca 2+ ] i ) with an oscillatory pattern in isolated perfused kidney inner…”
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Intestine-Specific NHE3 Deletion in Adulthood Causes Microbial Dysbiosis by Xue, Jianxiang, Dominguez Rieg, Jessica A., Thomas, Linto, White, James R., Rieg, Timo

“…In the intestine, the Na + /H + exchanger 3 (NHE3) plays a critical role for Na + and fluid absorption. NHE3 deficiency predisposes patients to inflammatory…”
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A role for the organic anion transporter OAT3 in renal creatinine secretion in mice by Vallon, Volker, Eraly, Satish A, Rao, Satish Ramachandra, Gerasimova, Maria, Rose, Michael, Nagle, Megha, Anzai, Naohiko, Smith, Travis, Sharma, Kumar, Nigam, Sanjay K, Rieg, Timo

“…Tubular secretion of the organic cation, creatinine, limits its value as a marker of glomerular filtration rate (GFR) but the molecular determinants of this…”
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Paracrine Regulation of the Epithelial Na+ Channel in the Mammalian Collecting Duct by Purinergic P2Y2 Receptor Tone by Pochynyuk, Oleh, Bugaj, Vladislav, Rieg, Timo, Insel, Paul A., Mironova, Elena, Vallon, Volker, Stockand, James D.

“…Growing evidence implicates a key role for extracellular nucleotides in cellular regulation, including of ion channels and renal function, but the mechanisms…”
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Cardiac-Specific Overexpression of Caveolin-3 Attenuates Cardiac Hypertrophy and Increases Natriuretic Peptide Expression and Signaling by Horikawa, Yousuke T., PhD, Panneerselvam, Mathivadhani, PhD, Kawaraguchi, Yoshitaka, MD, Tsutsumi, Yasuo M., MD, PhD, Ali, Sameh S., PhD, Balijepalli, Ravi C., PhD, Murray, Fiona, PhD, Head, Brian P., PhD, Niesman, Ingrid R., MS, Rieg, Timo, MD, Vallon, Volker, MD, Insel, Paul A., MD, Patel, Hemal H., PhD, Roth, David M., PhD, MD

“…Objectives We hypothesized that cardiac myocyte-specific overexpression of caveolin-3 (Cav-3), a muscle-specific caveolin, would alter natriuretic peptide…”
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Multiple organic anion transporters contribute to net renal excretion of uric acid by Eraly, Satish A, Vallon, Volker, Rieg, Timo, Gangoiti, Jon A, Wikoff, William R, Siuzdak, Gary, Barshop, Bruce A, Nigam, Sanjay K

“…1 Department of Medicine, University of California, San Diego 2 Department of Pharmacology, University of California, San Diego 4 Department of Pediatrics,…”
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Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics by Vallon, Volker, Rieg, Timo, Ahn, Sun Young, Wu, Wei, Eraly, Satish A, Nigam, Sanjay K

“…Organic anion transporter (OAT) genes have been implicated in renal secretion of organic anions, but the individual in vivo contributions of OAT1 (first…”
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Regulation of intestinal SGLT1 by catestatin in hyperleptinemic type 2 diabetic mice by Dominguez Rieg, Jessica A, Chirasani, Venkat R, Koepsell, Hermann, Senapati, Sanjib, Mahata, Sushil K, Rieg, Timo

“…The small intestine is the major site for nutrient absorption that is critical in maintenance of euglycemia. Leptin, a key hormone involved in energy…”
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Adenylate Cyclase 6 Determines cAMP Formation and Aquaporin-2 Phosphorylation and Trafficking in Inner Medulla by RIEG, Timo, TONG TANG, MURRAY, Fiona, SCHROTH, Jana, INSEL, Paul A, FENTON, Robert A, KIRK HAMMOND, H, VALLON, Volker

“…Arginine vasopressin (AVP) enhances water reabsorption in the renal collecting duct by vasopressin V₂ receptor (V₂R)-mediated activation of adenylyl cyclase…”
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