Search Results - "Riedel, Klaus‐Dieter"

Trimethoprim–metformin interaction and its genetic modulation by OCT2 and MATE1 transporters by Grün, Barbara, Kiessling, Michael K., Burhenne, Jürgen, Riedel, Klaus‐Dieter, Weiss, Johanna, Rauch, Geraldine, Haefeli, Walter E., Czock, David

“…Aims Metformin pharmacokinetics depends on the presence and activity of membrane‐bound drug transporters and may be affected by transport inhibitors. The aim…”
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Pharmacokinetics, metabolism and bioavailability of the triazole antifungal agent voriconazole in relation to CYP2C19 genotype by Scholz, Ina, Oberwittler, Heike, Riedel, Klaus‐Dieter, Burhenne, Jürgen, Weiss, Johanna, Haefeli, Walter E., Mikus, Gerd

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Pharmacokinetic variability of voriconazole is largely caused by CYP3A4‐ and CYP2C19‐mediated metabolism. • Oral…”
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Importance of ethnicity, CYP2B6 and ABCB1 genotype for efavirenz pharmacokinetics and treatment outcomes: a parallel-group prospective cohort study in two sub-Saharan Africa populations by Ngaimisi, Eliford, Habtewold, Abiy, Minzi, Omary, Makonnen, Eyasu, Mugusi, Sabina, Amogne, Wondwossen, Yimer, Getnet, Riedel, Klaus-Dieter, Janabi, Mohammed, Aderaye, Getachew, Mugusi, Ferdinand, Bertilsson, Leif, Aklillu, Eleni, Burhenne, Juergen

“…We evaluated the importance of ethnicity and pharmacogenetic variations in determining efavirenz pharmacokinetics, auto-induction and immunological outcomes in…”
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Pharmacogenetic & pharmacokinetic biomarker for efavirenz based ARV and rifampicin based anti-TB drug induced liver injury in TB-HIV infected patients by Yimer, Getnet, Ueda, Nobuhisa, Habtewold, Abiy, Amogne, Wondwossen, Suda, Akira, Riedel, Klaus-Dieter, Burhenne, Jürgen, Aderaye, Getachew, Lindquist, Lars, Makonnen, Eyasu, Aklillu, Eleni

“…Implication of pharmacogenetic variations and efavirenz pharmacokinetics in concomitant efavirenz based antiviral therapy and anti-tubercular drug induced…”
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Quantification of femtomolar concentrations of the CYP3A substrate midazolam and its main metabolite 1′-hydroxymidazolam in human plasma using ultra performance liquid chromatography coupled to tandem mass spectrometry by Burhenne, Jürgen, Halama, Birte, Maurer, Monika, Riedel, Klaus-Dieter, Hohmann, Nicolas, Mikus, Gerd, Haefeli, Walter E.

“…The benzodiazepine midazolam is a probe drug used to phenotype cytochrome P450 3A activity. In this situation, effective sedative concentrations are neither…”
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Pharmacokinetics of Sulfobutylether-Beta-Cyclodextrin and Voriconazole in Patients with End-Stage Renal Failure during Treatment with Two Hemodialysis Systems and Hemodiafiltration by HAFNER, Verena, CZOCK, David, BURHENNE, Jürgen, RIEDET, Klaus-Dieter, BOMMER, Jürgen, MIKUS, Gerd, MACHLEIDT, Christoph, WEINREICH, Thomas, HAEFELI, Walter E

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Liver enzyme abnormalities and associated risk factors in HIV patients on efavirenz-based HAART with or without tuberculosis co-infection in Tanzania by Mugusi, Sabina, Ngaimisi, Eliford, Janabi, Mohamed, Minzi, Omary, Bakari, Muhammad, Riedel, Klaus-Dieter, Burhenne, Juergen, Lindquist, Lars, Mugusi, Ferdinand, Sandstrom, Eric, Aklillu, Eleni

“…To investigate the timing, incidence, clinical presentation, pharmacokinetics and pharmacogenetic predictors for antiretroviral and anti-tuberculosis drug…”
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Clarithromycin substantially increases steady‐state bosentan exposure in healthy volunteers by Markert, Christoph, Schweizer, Yvonne, Hellwig, Regina, Wirsching, Theresia, Riedel, Klaus‐Dieter, Burhenne, Juergen, Weiss, Johanna, Mikus, Gerd, Haefeli, Walter E.

“…Aims The aim of this study was to assess the effect of the cytochrome P450 (CYP) 3A4 and organic anion‐transporting polypeptide (OATP) 1B1 inhibitor…”
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Contribution of CYP2C19 and CYP3A4 to the formation of the active nortilidine from the prodrug tilidine by Grün, Barbara, Merkel, Ulrike, Riedel, Klaus‐Dieter, Weiss, Johanna, Mikus, Gerd

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • The analgesic activity of tilidine is mediated by its active metabolite, nortilidine, which easily penetrates the…”
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Potent cytochrome P450 2C19 genotype-related interaction between voriconazole and the cytochrome P450 3A4 inhibitor ritonavir by Mikus, Gerd, Schöwel, Verena, Drzewinska, Magdalena, Rengelshausen, Jens, Ding, Reinhard, Riedel, Klaus‐Dieter, Burhenne, Jürgen, Weiss, Johanna, Thomsen, Torben, Haefeli, Walter E.

“…Objectives Cytochrome P450 (CYP) 2C19 and CYP3A4 are the major enzymes responsible for voriconazole elimination. Because the activity of CYP2C19 is under…”
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The NK1 receptor antagonist aprepitant does not alter the pharmacokinetics of high‐dose melphalan chemotherapy in patients with multiple myeloma by Egerer, Gerlinde, Eisenlohr, Kathrin, Gronkowski, Martina, Burhenne, Juergen, Riedel, Klaus‐Dieter, Mikus, Gerd

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Nausea and vomiting are the most distressing side‐effects of a high dose melphalan regimen. • Aprepitant in addition…”
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Modulators of Very Low Voriconazole Concentrations in Routine Therapeutic Drug Monitoring by HASSAN, Arwa, BURHENNE, Jürgen, RIEDEL, Klaus-Dieter, WEISS, Johanna, MIKUS, Gerd, HAEFELI, Waster E, CZOCK, David

“…Very low voriconazole concentrations are commonly observed during therapeutic drug monitoring. Possible mechanisms include inappropriate dose selection, rapid…”
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Substantial pharmacokinetic interaction between digoxin and ritonavir in healthy volunteers by Ding, Reinhard, Tayrouz, Yorki, Riedel, Klaus‐Dieter, Burhenne, Jürgen, Weiss, Johanna, Mikus, Gerd, Haefeli, Walter E.

“…Background Ritonavir is a potent in vitro inhibitor of several cytochrome P450 isozymes and ABC transporters including the efflux pump P‐glycoprotein (P‐gp)…”
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Opposite effects of short-term and long-term St John's wort intake on voriconazole pharmacokinetics by Rengelshausen, Jens, Banfield, Maria, Riedel, Klaus‐Dieter, Burhenne, Jürgen, Weiss, Johanna, Thomsen, Torben, Walter‐Sack, Ingeborg, Haefeli, Walter E., Mikus, Gerd

“…Objectives Constituents of St John's wort (SJW) in vivo induce the cytochrome P450 (CYP) isozymes 3A4, 2C9, and 2C19 but in vitro were shown to inhibit them…”
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Contribution of increased oral bioavailability and reduced nonglomerular renal clearance of digoxin to the digoxin–clarithromycin interaction by Rengelshausen, Jens, Göggelmann, Christoph, Burhenne, Jürgen, Riedel, Klaus‐Dieter, Ludwig, Jochen, Weiss, Johanna, Mikus, Gerd, Walter‐Sack, Ingeborg, Haefeli, Walter E.

“…Aims  A clinically important interaction between the cardiac glycoside digoxin and the antibiotic clarithromycin has been suggested in earlier reports. The aim…”
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Inhibition of the active principle of the weak opioid tilidine by the triazole antifungal voriconazole by Grün, Barbara, Krautter, Stefanie, Riedel, Klaus‐Dieter, Mikus, Gerd

“…WHAT IS ALREADY KNOWN ABOUT THE SUBJECT • Tilidine, a World Health Organization level II analgesic, is a high extraction drug subject to pronounced first‐pass…”
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Pharmacokinetic and pharmaceutic interaction between digoxin and Cremophor RH40 by Tayrouz, Yorki, Ding, Reinhard, Burhenne, Jürgen, Riedel, Klaus‐Dieter, Weiss, Johanna, Hoppe‐Tichy, Torsten, Haefeli, Walter Emil, Mikus, Gerd

“…Background The pharmacokinetics of digoxin is modulated by the efflux pump P‐glycoprotein. Cremophor EL (BASF Aktiengesellschaft, Ludwigshafen, Germany)…”
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Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine by Meissner, Peter E, Mandi, Germain, Coulibaly, Boubacar, Witte, Steffen, Tapsoba, Théophile, Mansmann, Ulrich, Rengelshausen, Jens, Schiek, Wolfgang, Jahn, Albrecht, Walter-Sack, Ingeborg, Mikus, Gerd, Burhenne, Jürgen, Riedel, Klaus-Dieter, Schirmer, R Heiner, Kouyaté, Bocar, Müller, Olaf

“…The development of safe, effective and affordable drug combinations against malaria in Africa is a public health priority. Methylene blue (MB) has a similar…”
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Quantification of cationic anti-malaria agent methylene blue in different human biological matrices using cation exchange chromatography coupled to tandem mass spectrometry by Burhenne, Jürgen, Riedel, Klaus-Dieter, Rengelshausen, Jens, Meissner, Peter, Müller, Olaf, Mikus, Gerd, Haefeli, Walter E., Walter-Sack, Ingeborg

“…Selective and sensitive methods for the determination of the cationic dye and anti-malarial methylene blue in human liquid whole blood, dried whole blood…”
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Undeclared exposure to St. John's Wort in hospitalized patients by Martin‐Facklam, Meret, Rieger, Karin, Riedel, Klaus‐Dieter, Burhenne, Jürgen, Walter‐Sack, Ingeborg, Haefeli, Walter E.

“…Aim The herbal medicine St. John's Wort (SJW) causes substantial decreases in the plasma concentrations of a range of co‐administered drugs. Therefore, we…”
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