Search Results - "Ried, T"

Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia by Calado, R T, Cooper, J N, Padilla-Nash, H M, Sloand, E M, Wu, C O, Scheinberg, P, Ried, T, Young, N S

“…In cell and animal models, telomere erosion promotes chromosomal instability via breakage-fusion-bridge cycles, contributing to the early stages of…”
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Correction to: Rb inactivation accelerates neoplastic growth and substitutes for recurrent amplification of cIAP1, cIAP2 and Yap1 in sporadic mammary carcinoma associated with p53 deficiency by Cheng, L., Zhou, Z., Flesken-Nikitin, A., Toshkov, I. A., Wang, W., Camps, J., Ried, T., Nikitin, A. Y.

“…A Correction to this paper has been published: https://doi.org/10.1038/s41388-021-01647-2…”
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CASZ1, a candidate tumor-suppressor gene, suppresses neuroblastoma tumor growth through reprogramming gene expression by Liu, Z, Yang, X, Li, Z, McMahon, C, Sizer, C, Barenboim-Stapleton, L, Bliskovsky, V, Mock, B, Ried, T, London, W B, Maris, J, Khan, J, Thiele, C J

“…Neuroblastoma (NB) is a common childhood malignant tumor of the neural crest-derived sympathetic nervous system. In NB the frequent loss of heterozygosity…”
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Cancer driver–passenger distinction via sporadic human and dog cancer comparison: a proof-of-principle study with colorectal cancer by Tang, J, Li, Y, Lyon, K, Camps, J, Dalton, S, Ried, T, Zhao, S

“…Herein we report a proof-of-principle study illustrating a novel dog–human comparison strategy that addresses a central aim of cancer research, namely cancer…”
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Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53 by Fishler, T, Li, Y-Y, Wang, R-H, Kim, H-S, Sengupta, K, Vassilopoulos, A, Lahusen, T, Xu, X, Lee, M-H, Liu, Q, Elledge, S-J, Ried, T, Deng, C-X

“…Checkpoint kinase 1 (Chk1) is a key element in the DNA-damage response pathway that is required for maintaining genomic stability. To study the potential role…”
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Multicolor Spectral Karyotyping of Human Chromosomes by Schröck, E., du Manoir, S., Veldman, T., Schoell, B., Wienberg, J., Ferguson-Smith, M. A., Ning, Y., Ledbetter, D. H., Bar-Am, I., Soenksen, D., Garini, Y., Ried, T.

“…The simultaneous and unequivocal discernment of all human chromosomes in different colors would be of significant clinical and biologic importance…”
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Rb inactivation accelerates neoplastic growth and substitutes for recurrent amplification of cIAP1, cIAP2 and Yap1 in sporadic mammary carcinoma associated with p53 deficiency by Cheng, L, Zhou, Z, Flesken-Nikitin, A, Toshkov, I A, Wang, W, Camps, J, Ried, T, Nikitin, A Y

“…Genetically defined mouse models offer an important tool to identify critical secondary genetic alterations with relevance to human cancer pathogenesis. We…”
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Ki-67 expression predicts locoregional recurrence in stage I oral tongue carcinoma by Wangsa, D, Ryott, M, Åvall-Lundqvist, E, Petersson, F, Elmberger, G, Luo, J, Ried, T, Auer, G, Munck-Wikland, E

“…Oral tongue squamous cell carcinoma (OTSCC) is an aggressive cancer associated with poor prognosis. Methods for determining the aggressiveness of OTSCC from…”
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CASZ1, a candidate tumor-suppressor gene, suppresses neuroblastoma tumor growth through reprogramming gene expression by Liu, Z, Yang, X, Li, Z, McMahon, C, Sizer, C, Barenboim-Stapleton, L, Bliskovsky, V, Mock, B, Ried, T, London, W B, Maris, J, Khan, J, Thiele, C J

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MicroRNA-24 regulates XIAP to reduce the apoptosis threshold in cancer cells by Xie, Y, Tobin, L A, Camps, J, Wangsa, D, Yang, J, Rao, M, Witasp, E, Awad, K S, Yoo, N, Ried, T, Kwong, K F

“…MicroRNAs have been implicated as important mediators of cancer cell homeostasis, and accumulating data suggest compelling roles for them in the apoptosis…”
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Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3 by Chesi, Marta, Nardini, Elena, Brents, Leslie A, Schröck, Evelin, Ried, Thomas, Kuehl, W. Michael, Bergsagel, P. Leif

“…Dysregulation of oncogenes by translocation to the IgH locus (14q32) is a seminal event in the pathogenesis of B-cell tumours. In multiple myeloma (MM),…”
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Response to RAG-Mediated V(D)J Cleavage by NBS1 and γ-H2AX by Chen, Hua Tang, Bhandoola, Avinash, Difilippantonio, Michael J., Zhu, Jie, Brown, Martin J., Tai, Xuguang, Rogakou, Emmy P., Brotz, Tilmann M., Bonner, William M., Ried, Thomas, Nussenzweig, André

“…Genetic disorders affecting cellular responses to DNA damage are characterized by high rates of translocations involving antigen receptor loci and increased…”
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Atm deficiency results in severe meiotic disruption as early as leptonema of prophase I by Barlow, C, Liyanage, M, Moens, P B, Tarsounas, M, Nagashima, K, Brown, K, Rottinghaus, S, Jackson, S P, Tagle, D, Ried, T, Wynshaw-Boris, A

“…Infertility is a common feature of the human disorder ataxia-telangiectasia and Atm-deficient mice are completely infertile. To gain further insight into the…”
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Aneuploidy, oncogene amplification and epithelial to mesenchymal transition define spontaneous transformation of murine epithelial cells by Padilla-Nash, Hesed M, McNeil, Nicole E, Yi, Ming, Nguyen, Quang-Tri, Hu, Yue, Wangsa, Danny, Mack, David L, Hummon, Amanda B, Case, Chanelle, Cardin, Eric, Stephens, Robert, Difilippantonio, Michael J, Ried, Thomas

“…Human epithelial cancers are defined by a recurrent distribution of specific chromosomal aneuploidies, a trait less typical for murine cancer models induced by…”
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Haploinsufficiency of Parp1 accelerates Brca1-associated centrosome amplification, telomere shortening, genetic instability, apoptosis, and embryonic lethality by Wang, X, Liu, L, Montagna, C, Ried, T, Deng, C-X

“…The breast tumor associated gene-1 (BRCA1) and poly(ADP-ribose) polymerase-1 (PARP1) are both involved in DNA-damage response and DNA-damage repair. Recent…”
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BCR ABL induces chromosomal instability after genotoxic stress and alters the cell death threshold by Dierov, J, Sanchez, P V, Burke, B A, Padilla-Nash, H, Putt, M E, Ried, T, Carroll, M

“…Earlier reports have suggested that the BCR/ABL oncogene, associated with chronic myeloid leukemia, induces a mutator phenotype; however, it is unclear whether…”
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Gain of Chromosome 3q Defines the Transition from Severe Dysplasia to Invasive Carcinoma of the Uterine Cervix by Heselmeyer, Kerstin, Schröck, Evelin, Du Manoir, Stanislas, Blegen, Harald, Shah, Keerti, Steinbeck, Rüdiger, Auer, Gert, Ried, Thomas

“…We have chosen tumors of the uterine cervix as a model system to identify chromosomal aberrations that occur during carcinogenesis. A phenotype/genotype…”
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Frequent gain of the human telomerase gene TERC at 3q26 in cervical adenocarcinomas by ANDERSSON, S, WALLIN, K.-L, HELLSTRÖM, A.-C, MORRISON, L. E, HJERPE, A, AUER, G, RIED, T, LARSSON, C, HESELMEVER-HADDAD, K

“…The level of genomic amplification of the human telomerase gene TERC, which maps to chromosome band 3q26, was determined in primary cervical adenocarcinomas…”
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Abnormal rearrangement within the α/δ T-cell receptor locus in lymphomas from Atm-deficient mice by Liyanage, Marek, Weaver, Zoë, Barlow, Carrolee, Coleman, Allen, Pankratz, Daniel G., Anderson, Stacie, Wynshaw-Boris, Anthony, Ried, Thomas

“…Atm-deficient mice (Atm−/−) recapitulate many aspects of the ataxia telangiectasia (AT) syndrome, including the susceptibility to tumors of lymphoid origin. To…”
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Characterisation of breast fine-needle aspiration biopsies by centrosome aberrations and genomic instability by KRONENWETT, U, HUWENDIEK, S, CASTRO, J, RIED, T, AUER, G

“…Recent studies have suggested that aneuploidy in malignant tumours could be a consequence of centrosome aberrations. Using immunofluorescence analysis with an…”
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