Search Results - "Ridpath, John R"

Acid-specific formaldehyde donor is a potential, dual targeting cancer chemotherapeutic/chemo preventive drug for FANC/BRCA-mutant cancer by Ridpath, John R, Nakamura, Jun

“…[Abstract] Background: Development of chemotherapeutic/preventive drugs that selectively kill cancer - the Holy Grail of cancer research - is a major…”
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Homologous Recombination and Translesion DNA Synthesis Play Critical Roles on Tolerating DNA Damage Caused by Trace Levels of Hexavalent Chromium by Tian, Xu, Patel, Keyur, Ridpath, John R, Chen, Youjun, Zhou, Yi-Hui, Neo, Dayna, Clement, Jean, Takata, Minoru, Takeda, Shunichi, Sale, Julian, Wright, Fred A, Swenberg, James A, Nakamura, Jun

“…Contamination of potentially carcinogenic hexavalent chromium (Cr(VI)) in the drinking water is a major public health concern worldwide. However, little…”
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Cells Deficient in the FANC/BRCA Pathway Are Hypersensitive to Plasma Levels of Formaldehyde by RIDPATH, John R, NAKAMURA, Ayumi, BISHOP, Douglas K, TAKATA, Minoru, TAKEDA, Shunichi, WATANABE, Masami, SWENBERG, James A, NAKAMURA, Jun, TANO, Keizo, LUKE, April M, SONODA, Eiichiro, ARAKAWA, Hiroshi, BUERSTEDDE, Jean-Marie, GILLESPIE, David A. F, SALE, Julian E, YAMAZOE, Mitsuyoshi

“…Formaldehyde is an aliphatic monoaldehyde and is a highly reactive environmental human carcinogen. Whereas humans are continuously exposed to exogenous…”
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SWI/SNF complexes are required for full activation of the DNA-damage response by Smith-Roe, Stephanie L, Nakamura, Jun, Holley, Darcy, Chastain, 2nd, Paul D, Rosson, Gary B, Simpson, Dennis A, Ridpath, John R, Kaufman, David G, Kaufmann, William K, Bultman, Scott J

“…SWI/SNF complexes utilize BRG1 (also known as SMARCA4) or BRM (also known as SMARCA2) as alternative catalytic subunits with ATPase activity to remodel…”
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Convenient, multi-well plate-based DNA damage response analysis using DT40 mutants is applicable to a high-throughput genotoxicity assay with characterization of modes of action by Ridpath, John R., Takeda, Shunichi, Swenberg, James A., Nakamura, Jun

“…Chemists continually synthesize myriad new chemicals (∼2,000/year), some of which make their way into the environment or otherwise pose possible threats to…”
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Abstract 5363: Genotoxicity of trace level of hexavalent chromium existing in city water by Tian, Xu, Patel, Keyur, Ridpath, John R., Swenberg, James A., Nakamura, Jun

“…Tens of millions of Americans consume trace amounts of potentially toxic hexavalent chromium (Cr(VI)) through drinking city water every day. According to the…”
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Detecting DNA damage: The synthesis of new aldehyde reactive probes for the quantitation of apurinic/apyrimidinic sites by Ridpath, John R

“…Apurinic/apyrimidinic (abasic) sites are some of the most common lesions found in DNA. They are postulated to be intermediates of mutagenicity and…”
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