Search Results - "Ridlon, M"

Taurocholic acid metabolism by gut microbes and colon cancer by Ridlon, Jason M., Wolf, Patricia G., Gaskins, H. Rex

“…Colorectal cancer (CRC) is one of the most frequent causes of cancer death worldwide and is associated with adoption of a diet high in animal protein and…”
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The Hylemon-Björkhem pathway of bile acid 7-dehydroxylation: history, biochemistry, and microbiology by Ridlon, Jason M., Daniel, Steven L., Gaskins, H. Rex

“…Bile acids are detergents derived from cholesterol that function to solubilize dietary lipids, remove cholesterol from the body, and act as nutrient signaling…”
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Bile salt biotransformations by human intestinal bacteria by Ridlon, Jason M, Kang, Dae-Joong, Hylemon, Phillip B

“…Secondary bile acids, produced solely by intestinal bacteria, can accumulate to high levels in the enterohepatic circulation of some individuals and may…”
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Modulation of the fecal bile acid profile by gut microbiota in cirrhosis by Kakiyama, Genta, Pandak, William M, Gillevet, Patrick M, Hylemon, Phillip B, Heuman, Douglas M, Daita, Kalyani, Takei, Hajime, Muto, Akina, Nittono, Hiroshi, Ridlon, Jason M, White, Melanie B, Noble, Nicole A, Monteith, Pamela, Fuchs, Michael, Thacker, Leroy R, Sikaroodi, Masoumeh, Bajaj, Jasmohan S

“…Background & Aims The 7α-dehydroxylation of primary bile acids (BAs), chenodeoxycholic (CDCA) and cholic acid (CA) into the secondary BAs, lithocholic (LCA)…”
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Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation by Bajaj, Jasmohan S, Hylemon, Phillip B, Ridlon, Jason M, Heuman, Douglas M, Daita, Kalyani, White, Melanie B, Monteith, Pamela, Noble, Nicole A, Sikaroodi, Masoumeh, Gillevet, Patrick M

“…Although hepatic encephalopathy (HE) is linked to the gut microbiota, stool microbiome analysis has not found differences between HE and no-HE patients. This…”
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Identification and characterization of two bile acid coenzyme A transferases from Clostridium scindens, a bile acid 7α-dehydroxylating intestinal bacterium by Ridlon, Jason M., Hylemon, Phillip B.

“…The human bile acid pool composition is composed of both primary bile acids (cholic acid and chenodeoxycholic acid) and secondary bile acids (deoxycholic acid…”
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Clostridium scindens: a human gut microbe with a high potential to convert glucocorticoids into androgens by Ridlon, Jason M., Ikegawa, Shigeo, Alves, João M.P., Zhou, Biao, Kobayashi, Akiko, Iida, Takashi, Mitamura, Kuniko, Tanabe, Genzoh, Serrano, Myrna, De Guzman, Ainee, Cooper, Patsy, Buck, Gregory A., Hylemon, Phillip B.

“…Clostridium scindens American Type Culture Collection 35704 is capable of converting primary bile acids to toxic secondary bile acids, as well as converting…”
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Microbial Hydroxysteroid Dehydrogenases: From Alpha to Omega by Doden, Heidi L, Ridlon, Jason M

“…Bile acids (BAs) and glucocorticoids are steroid hormones derived from cholesterol that are important signaling molecules in humans and other vertebrates…”
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Modulation of the metabiome by rifaximin in patients with cirrhosis and minimal hepatic encephalopathy by Bajaj, Jasmohan S, Heuman, Douglas M, Sanyal, Arun J, Hylemon, Phillip B, Sterling, Richard K, Stravitz, R Todd, Fuchs, Michael, Ridlon, Jason M, Daita, Kalyani, Monteith, Pamela, Noble, Nicole A, White, Melanie B, Fisher, Andmorgan, Sikaroodi, Masoumeh, Rangwala, Huzefa, Gillevet, Patrick M

“…Hepatic encephalopathy (HE) represents a dysfunctional gut-liver-brain axis in cirrhosis which can negatively impact outcomes. This altered gut-brain…”
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The desA and desB genes from Clostridium scindens ATCC 35704 encode steroid-17,20-desmolase[S] by Devendran, Saravanan, Mythen, Sean M., Ridlon, Jason M.

“…Clostridium scindens is a gut microbe capable of removing the side-chain of cortisol, forming 11β-hydro­xyandrostenedione. A cortisol-inducible operon…”
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Diversity and distribution of sulfur metabolic genes in the human gut microbiome and their association with colorectal cancer by Wolf, Patricia G, Cowley, Elise S, Breister, Adam, Matatov, Sarah, Lucio, Luke, Polak, Paige, Ridlon, Jason M, Gaskins, H Rex, Anantharaman, Karthik

“…Recent evidence implicates microbial sulfidogenesis as a potential trigger of colorectal cancer (CRC), highlighting the need for comprehensive knowledge of…”
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The human gut sterolbiome:bile acid-microbiome endocrine aspects and therapeutics by Ridlon, Jason M, Bajaj, Jasmohan S

“…The human body is now viewed as a complex ecosystem that on a cellular and gene level is mainly prokaryotic. The mammalian liver synthesizes and secretes…”
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Special Issue: Microbial Impact on Cholesterol and Bile Acid Metabolism by Ridlon, Jason M

“…An important current focus in microbiome science is the biotransformation and degradation of cholesterol, steroids, and bile acids [...]…”
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Colonic inflammation and secondary bile acids in alcoholic cirrhosis by Kakiyama, Genta, Hylemon, Phillip B, Zhou, Huiping, Pandak, William M, Heuman, Douglas M, Kang, Dae Joong, Takei, Hajime, Nittono, Hiroshi, Ridlon, Jason M, Fuchs, Michael, Gurley, Emily C, Wang, Yun, Liu, Runping, Sanyal, Arun J, Gillevet, Patrick M, Bajaj, Jasmohan S

“…Alcohol abuse with/without cirrhosis is associated with an impaired gut barrier and inflammation. Gut microbiota can transform primary bile acids (BA) to…”
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Identification and characterization of a 20β-HSDH from the anaerobic gut bacterium Butyricicoccus desmolans ATCC 43058[S] by Devendran, Saravanan, Méndez-García, Celia, Ridlon, Jason M.

“…Members of the gastrointestinal microbiota are known to convert glucocorticoids to androstanes, which are subsequently converted to potent androgens by other…”
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Completion of the gut microbial epi-bile acid pathway by Doden, Heidi L., Wolf, Patricia G., Gaskins, H. Rex, Anantharaman, Karthik, Alves, João M. P., Ridlon, Jason M.

“…Bile acids are detergent molecules that solubilize dietary lipids and lipid-soluble vitamins. Humans synthesize bile acids with α-orientation hydroxyl groups…”
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Clostridium scindens ATCC 35704: Integration of Nutritional Requirements, the Complete Genome Sequence, and Global Transcriptional Responses to Bile Acids by Devendran, Saravanan, Shrestha, Rachana, Alves, João M P, Wolf, Patricia G, Ly, Lindsey, Hernandez, Alvaro G, Méndez-García, Celia, Inboden, Ashley, Wiley, J'nai, Paul, Oindrila, Allen, Avery, Springer, Emily, Wright, Chris L, Fields, Christopher J, Daniel, Steven L, Ridlon, Jason M

“…In the human gut, ATCC 35704 is a predominant bacterium and one of the major bile acid 7α-dehydroxylating anaerobes. While this organism is well-studied…”
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The 'in vivo lifestyle' of bile acid 7α-dehydroxylating bacteria: comparative genomics, metatranscriptomic, and bile acid metabolomics analysis of a defined microbial community in gnotobiotic mice by Ridlon, Jason M., Devendran, Saravanan, Alves, João Mp, Doden, Heidi, Wolf, Patricia G., Pereira, Gabriel V., Ly, Lindsey, Volland, Alyssa, Takei, Hajime, Nittono, Hiroshi, Murai, Tsuyoshi, Kurosawa, Takao, Chlipala, George E., Green, Stefan J., Hernandez, Alvaro G., Fields, Christopher J., Wright, Christy L., Kakiyama, Genta, Cann, Isaac, Kashyap, Purna, McCracken, Vance, Gaskins, H. Rex

“…The formation of secondary bile acids by gut microbes is a current topic of considerable biomedical interest. However, a detailed understanding of the biology…”
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Berberine alters gut microbial function through modulation of bile acids by Wolf, Patricia G, Devendran, Saravanan, Doden, Heidi L, Ly, Lindsey K, Moore, Tyler, Takei, Hajime, Nittono, Hiroshi, Murai, Tsuyoshi, Kurosawa, Takao, Chlipala, George E, Green, Stefan J, Kakiyama, Genta, Kashyap, Purna, McCracken, Vance J, Gaskins, H Rex, Gillevet, Patrick M, Ridlon, Jason M

“…Berberine (BBR) is a plant-based nutraceutical that has been used for millennia to treat diarrheal infections and in contemporary medicine to improve patient…”
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Formation of secondary allo-bile acids by novel enzymes from gut Firmicutes by Lee, Jae Won, Cowley, Elise S., Wolf, Patricia G., Doden, Heidi L., Murai, Tsuyoshi, Caicedo, Kelly Yovani Olivos, Ly, Lindsey K., Sun, Furong, Takei, Hajime, Nittono, Hiroshi, Daniel, Steven L., Cann, Isaac, Gaskins, H. Rex, Anantharaman, Karthik, Alves, João M. P., Ridlon, Jason M.

“…The gut microbiome of vertebrates is capable of numerous biotransformations of bile acids, which are responsible for intestinal lipid digestion and function as…”
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