Search Results - "Ridley, Anne"

Rho GTPase signalling in cell migration by Ridley, Anne J

“…Cells migrate in multiple different ways depending on their environment, which includes the extracellular matrix composition, interactions with other cells,…”
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Life at the Leading Edge by Ridley, Anne J.

“…Cell migration requires sustained forward movement of the plasma membrane at the cell's front or “leading edge.” To date, researchers have uncovered four…”
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Endothelial cell-cell adhesion and signaling by Cerutti, Camilla, Ridley, Anne J.

“…Endothelial cells line blood vessels and provide a dynamic interface between the blood and tissues. They remodel to allow leukocytes, fluid and small molecules…”
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Rho GTPase signaling complexes in cell migration and invasion by Lawson, Campbell D, Ridley, Anne J

“…Cell migration is dependent on the dynamic formation and disassembly of actin filament-based structures, including lamellipodia, filopodia, invadopodia, and…”
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Regulating Rho GTPases and their regulators by Hodge, Richard G., Ridley, Anne J.

“…Key Points Rho GTPases regulate a wide range of cellular responses, including changes to the cytoskeleton and cell adhesion. Their activity therefore needs to…”
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Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking by Ridley, Anne J.

“…Rho GTPases are well known to regulate actin dynamics. They activate two types of actin nucleators, WASP/WAVE proteins and Diaphanous-related formins (DRFs),…”
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Crossing the endothelial barrier during metastasis by Reymond, Nicolas, d'Água, Bárbara Borda, Ridley, Anne J.

“…Key Points To form metastases, cancer cells twice cross the endothelial cells that line blood vessels (once during intravasation and once during…”
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The Function of Rho-Associated Kinases ROCK1 and ROCK2 in the Pathogenesis of Cardiovascular Disease by Hartmann, Svenja, Ridley, Anne J, Lutz, Susanne

“…Rho-associated kinases ROCK1 and ROCK2 are serine/threonine kinases that are downstream targets of the small GTPases RhoA, RhoB, and RhoC. ROCKs are involved…”
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Rho GTPases: Regulation and roles in cancer cell biology by Haga, Raquel B., Ridley, Anne J.

“…Rho GTPases are well known for their roles in regulating cell migration, and also contribute to a variety of other cellular responses. They are subdivided into…”
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Mammalian Rho GTPases: new insights into their functions from in vivo studies by Heasman, Sarah J, Ridley, Anne J

“…Key Points There are 20 members of the Rho GTPase family in mammals; all eukaryotes have several Rho GTPases. Rho GTPases regulate cytoskeletal dynamics, cell…”
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Targeting Rho GTPase Signaling Networks in Cancer by Clayton, Natasha S, Ridley, Anne J

“…As key regulators of cytoskeletal dynamics, Rho GTPases coordinate a wide range of cellular processes, including cell polarity, cell migration, and cell cycle…”
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Proneural Transcription Factors Regulate Different Steps of Cortical Neuron Migration through Rnd-Mediated Inhibition of RhoA Signaling by Pacary, Emilie, Heng, Julian, Azzarelli, Roberta, Riou, Philippe, Castro, Diogo, Lebel-Potter, Mélanie, Parras, Carlos, Bell, Donald M., Ridley, Anne J., Parsons, Maddy, Guillemot, François

“…Little is known of the intracellular machinery that controls the motility of newborn neurons. We have previously shown that the proneural protein Neurog2…”
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Rho GTPases in cancer cell biology by Vega, Francisco M., Ridley, Anne J.

“…Rho GTPases contribute to multiple cellular processes that could affect cancer progression, including cytoskeletal dynamics, cell cycle progression,…”
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RhoA and RhoC have distinct roles in migration and invasion by acting through different targets by Vega, Francisco M, Fruhwirth, Gilbert, Ng, Tony, Ridley, Anne J

“…Several studies suggest that RhoA and RhoC, despite their sequence similarity, have different roles in cell migration and invasion, but the molecular basis for…”
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Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2 by Lucotti, Serena, Cerutti, Camilla, Soyer, Magali, Gil-Bernabé, Ana M, Gomes, Ana L, Allen, Philip D, Smart, Sean, Markelc, Bostjan, Watson, Karla, Armstrong, Paul C, Mitchell, Jane A, Warner, Timothy D, Ridley, Anne J, Muschel, Ruth J

“…Because metastasis is associated with the majority of cancer-related deaths, its prevention is a clinical aspiration. Prostanoids are a large family of…”
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Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane [A.sub.2] by Lucotti, Serena, Cerutti, Camilla, Soyer, Magali, Gil-Bernabe, Ana M, Gomes, Ana L, Allen, Philip D, Smart, Sean, Markelc, Bostjan, Watson, Karla, Armstrong, Paul C, Mitchell, Jane A, Warner, Timothy D, Ridley, Anne J, Muschel, Ruth J

“…Because metastasis is associated with the majority of cancer-related deaths, its prevention is a clinical aspiration. Prostanoids are a large family of…”
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Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration by Bai, Siau Wei, Herrera-Abreu, Maria Teresa, Rohn, Jennifer L, Racine, Victor, Tajadura, Virginia, Suryavanshi, Narendra, Bechtel, Stephanie, Wiemann, Stefan, Baum, Buzz, Ridley, Anne J

“…Cell migration is essential during development and in human disease progression including cancer. Most cell migration studies concentrate on known or predicted…”
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The RhoB small GTPase in physiology and disease by Vega, Francisco M., Ridley, Anne J.

“…RhoB is a Rho family GTPase that is highly similar to RhoA and RhoC, yet has distinct functions in cells. Its unique C-terminal region is subject to specific…”
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Microtubules regulate migratory polarity through Rho/ROCK signaling in T cells by Takesono, Aya, Heasman, Sarah J, Wojciak-Stothard, Beata, Garg, Ritu, Ridley, Anne J

“…Migrating leukocytes normally have a polarized morphology with an actin-rich lamellipodium at the front and a uropod at the rear. Microtubules (MTs) are…”
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ROCKs: multifunctional kinases in cell behaviour by Riento, Kirsi, Ridley, Anne J

“…ROCKs, or Rho kinases, are serine/threonine kinases that are involved in many aspects of cell motility, from smooth-muscle contraction to cell migration and…”
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