Search Results - "Ridley, A.J."

RhoA, RhoB and RhoC have different roles in cancer cell migration by RIDLEY, A.J.

“…Summary Rho GTPases are well known to regulate cell motility through activation of a variety of downstream effector proteins, including enzymes, adaptor…”
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Regulation of macrophage adhesion and migration by Rho GTP-binding proteins by RIDLEY, A.J

“…The Rho family proteins Rac and Rho are believed to be key regulators of cell migration through their effects on the cytoskeleton and cell adhesion. However,…”
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Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages by Allen, W E, Jones, G E, Pollard, J W, Ridley, A J

“…Rho family proteins are known to regulate actin organization in fibroblasts, but their functions in cells of haematopoietic origin have not been studied in…”
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A model of localised Rac1 activation in endothelial cells due to fluid flow by Allen, R.J., Bogle, I.D.L., Ridley, A.J.

“…Endothelial cells respond to fluid flow by elongating in the direction of flow. Cytoskeletal changes and activation of signalling molecules have been…”
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The magnetospheric and ionospheric response to a very strong interplanetary shock and coronal mass ejection by Ridley, A.J., De Zeeuw, D.L., Manchester, W.B., Hansen, K.C.

“…We present results from a coupled magnetospheric and ionospheric simulation of a very strong solar wind shock and coronal mass ejection (CME). The solar wind…”
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GIT1 Mediates Thrombin Signaling in Endothelial Cells: Role in Turnover of RhoA-Type Focal Adhesions by van Nieuw Amerongen, Geerten P, Natarajan, Kanchana, Yin, Guoyong, Hoefen, Ryan J, Osawa, M, Haendeler, Judith, Ridley, A.J, Fujiwara, K, van Hinsbergh, Victor W.M, Berk, Bradford C

“…ABSTRACT—Thrombin mediates changes in endothelial barrier function and increases endothelial permeability. A feature of thrombin-enhanced endothelial…”
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Modeling the Sun-to-Earth propagation of a very fast CME by Manchester, W.B., Ridley, A.J., Gombosi, T.I., DeZeeuw, D.L.

“…We present a three-dimensional (3-D) numerical ideal magnetohydrodynamics (MHD) model describing the time-dependent propagation of a CME from the solar corona…”
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Estimations of the uncertainty in timing the relationship between magnetospheric and solar wind processes by Ridley, A.J.

“…We present here a statistical study quantifying the errors associated with the most commonly used methods for propagating discontinuities in the interplanetary…”
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Solution-adaptive magnetohydrodynamics for space plasmas: Sun-to-Earth simulations by Gombosi, T.I., Powell, K.G., De Zeeuw, D.L., Clauer, C.R., Hansen, K.C., Manchester, W.B., Ridley, A.J., Roussev, I.I., Sokolov, I.V., Stout, Q.F., Toth, G.

“…Space-environment simulations, particularly those involving space plasma, present significant computational challenges. Global computational models based on…”
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rho family GTPase activating proteins p190, bcr and rhoGAP show distinct specificities in vitro and in vivo by Ridley, A.J., Self, A.J., Kasmi, F., Paterson, H.F., Hall, A., Marshall, C.J., Ellis, C.

“…rho family GTPases link extracellular signals to changes in the organization of cytoskeletal actin. Serum stimulation of quiescent Swiss 3T3 fibroblasts leads…”
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The global ionosphere–thermosphere model by Ridley, A.J., Deng, Y., Tóth, G.

“…The recently created global ionosphere–thermosphere model (GITM) is presented. GITM uses a three-dimensional spherical grid that can be stretched in both…”
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3BP‐1, an SH3 domain binding protein, has GAP activity for Rac and inhibits growth factor‐induced membrane ruffling in fibroblasts by Cicchetti, P., Ridley, A.J., Zheng, Y., Cerione, R.A., Baltimore, D.

“…The SH3 binding protein, 3BP‐1, was originally cloned as a partial cDNA from an expression library using the Abl SH3 domain as a probe. In addition to an SH3…”
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Analysis of Rho GTPase expression in T-ALL identifies RhoU as a target for Notch involved in T-ALL cell migration by Bhavsar, P J, Infante, E, Khwaja, A, Ridley, A J

“…NOTCH1 is frequently mutated in T-cell acute lymphoblastic leukaemia (T-ALL), and can stimulate T-ALL cell survival and proliferation. Here we explore the…”
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Correction of the photoelectron heating efficiency within the global ionosphere‐thermosphere model using Retrospective Cost Model Refinement by Burrell, A.G., Goel, A., Ridley, A.J., Bernstein, D.S.

“…Many physics-based models are used to study and monitor the terrestrial upper atmosphere. Each of these models has internal parameterizations that introduce…”
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Phosphorylation of the WASP-VCA Domain Increases Its Affinity for the Arp2/3 Complex and Enhances Actin Polymerization by WASP by Cory, Giles O.C., Cramer, Rainer, Blanchoin, Laurent, Ridley, Anne J.

“…Wiskott-Aldrich syndrome protein (WASP) and neural (N)-WASP regulate dynamic actin structures through the ability of their VCA domains to bind to and stimulate…”
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Signal transduction pathways regulating Rho‐mediated stress fibre formation: requirement for a tyrosine kinase by Ridley, A.J., Hall, A.

“…Lysophosphatidic acid (LPA) and bombesin rapidly stimulate the formation of focal adhesions and actin stress fibres in serum‐starved Swiss 3T3 fibroblasts, a…”
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The telling tail of L-selectin by Ivetic, A, Ridley, A J

“…L-selectin is constitutively expressed on the surface of most leucocytes and is important for tethering and subsequent rolling of leucocytes on endothelial…”
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Reduced-rank unscented Kalman filtering using Cholesky-based decomposition by Chandrasekar, J., Kim, I.S., Bernstein, D.S., Ridley, A.J.

“…We consider a reduced-rank square-root unscented Kalman filter based on the Cholesky decomposition of the state-error covariance. The performance of this…”
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The GTP-binding protein Rho by Ridley, A.J.

“…RhoA, RhoB and RhoC are three closely related proteins, and are members of the Ras superfamily of small GTP-binding proteins. They bind and hydrolyse GTP, and…”
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Differential Effects of Immunosuppressive Drugs on T‐Cell Motility by Datta, A., David, R., Glennie, S., Scott, D., Cernuda‐Morollon, E., Lechler, R. I., Ridley, A. J., Marelli‐Berg, F. M.

“…The best‐characterized mechanism of the action of immunosuppressive drugs is to prevent T‐cell clonal expansion, thus containing the magnitude of the ensuing…”
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