Search Results - "Ridings, James E."

Species-specific Inflammatory Responses as a Primary Component for the Development of Glomerular Lesions in Mice and Monkeys Following Chronic Administration of a Second-generation Antisense Oligonucleotide by Frazier, Kendall S., Sobry, Cécile, Derr, Victoria, Adams, Mike J., Besten, Cathaline Den, Kimpe, Sjef De, Francis, Ian, Gales, Tracy L., Haworth, Richard, Maguire, Shaun R., Mirabile, Rosanna C., Mullins, David, Palate, Bernard, Doorten, Yolanda Ponstein-Simarro, Ridings, James E., Scicchitano, Marshall S., Silvano, Jérémy, Woodfine, Jennie

“…Chronic administration of drisapersen, a 2′-OMe phosphorothioate antisense oligonucleotide (AON) to mice and monkeys resulted in renal tubular accumulation,…”
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The thalidomide disaster, lessons from the past by Ridings, James E

“…It is close to 60 years since thalidomide was created by the German company, Chemie-Grünenthal, and launched as "Contergan." This was soon to be followed in…”
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Assessment of CNS safety in juvenile animals by Ridings, James E.

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Prenatal toxicity studies in rats and rabbits with the calcium channel blocker diproteverine by Ridings, James E., Palmer, Anthony K., Davidson, Elizabeth J., Baldwin, John A.

“…In prenatal toxicity studies, diproteverine, a calcium channel blocker with demonstrated antianginal properties, produced an unusual pattern of digital, heart,…”
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A qualitative assessment of developmental toxicity within a series of structurally related dopamine mimetics by Ridings, J E, Baldwin, J A

“…A qualitative assessment of developmental toxicity within a series of 12 structurally related compounds, 11 of which were active dopamine mimetics and one was…”
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Multivariate quantitative structure-toxicity relationships in a series of dopamine mimetics by Ridings, J E, Manallack, D T, Saunders, M R, Baldwin, J A, Livingstone, D J

“…The techniques of principal components analysis and non-linear mapping are routinely used by computer chemists at SmithKline Beecham Pharmaceuticals in the…”
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