Search Results - "Ridgway, Rachel"

MicroRNA-135b Promotes Cancer Progression by Acting as a Downstream Effector of Oncogenic Pathways in Colon Cancer by Valeri, Nicola, Braconi, Chiara, Gasparini, Pierluigi, Murgia, Claudio, Lampis, Andrea, Paulus-Hock, Viola, Hart, Jonathan R., Ueno, Lynn, Grivennikov, Sergei I., Lovat, Francesca, Paone, Alessio, Cascione, Luciano, Sumani, Khlea M., Veronese, Angelo, Fabbri, Muller, Carasi, Stefania, Alder, Hansjuerg, Lanza, Giovanni, Gafa’, Roberta, Moyer, Mary P., Ridgway, Rachel A., Cordero, Julia, Nuovo, Gerard J., Frankel, Wendy L., Rugge, Massimo, Fassan, Matteo, Groden, Joanna, Vogt, Peter K., Karin, Michael, Sansom, Owen J., Croce, Carlo M.

“…MicroRNA deregulation is frequent in human colorectal cancers (CRCs), but little is known as to whether it represents a bystander event or actually drives…”
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Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy by Tajan, Mylène, Hennequart, Marc, Cheung, Eric C., Zani, Fabio, Hock, Andreas K., Legrave, Nathalie, Maddocks, Oliver D. K., Ridgway, Rachel A., Athineos, Dimitris, Suárez-Bonnet, Alejandro, Ludwig, Robert L., Novellasdemunt, Laura, Angelis, Nikolaos, Li, Vivian S. W., Vlachogiannis, Georgios, Valeri, Nicola, Mainolfi, Nello, Suri, Vipin, Friedman, Adam, Manfredi, Mark, Blyth, Karen, Sansom, Owen J., Vousden, Karen H.

“…Many tumour cells show dependence on exogenous serine and dietary serine and glycine starvation can inhibit the growth of these cancers and extend survival in…”
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Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis by Jackstadt, Rene, van Hooff, Sander R., Leach, Joshua D., Cortes-Lavaud, Xabier, Lohuis, Jeroen O., Ridgway, Rachel A., Wouters, Valérie M., Roper, Jatin, Kendall, Timothy J., Roxburgh, Campbell S., Horgan, Paul G., Nixon, Colin, Nourse, Craig, Gunzer, Matthias, Clark, William, Hedley, Ann, Yilmaz, Omer H., Rashid, Mamunur, Bailey, Peter, Biankin, Andrew V., Campbell, Andrew D., Adams, David J., Barry, Simon T., Steele, Colin W., Medema, Jan Paul, Sansom, Owen J.

“…The metastatic process of colorectal cancer (CRC) is not fully understood and effective therapies are lacking. We show that activation of NOTCH1 signaling in…”
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ROS Production and NF-κB Activation Triggered by RAC1 Facilitate WNT-Driven Intestinal Stem Cell Proliferation and Colorectal Cancer Initiation by Myant, Kevin B., Cammareri, Patrizia, McGhee, Ewan J., Ridgway, Rachel A., Huels, David J., Cordero, Julia B., Schwitalla, Sarah, Kalna, Gabriela, Ogg, Erinn-Lee, Athineos, Dimitris, Timpson, Paul, Vidal, Marcos, Murray, Graeme I., Greten, Florian R., Anderson, Kurt I., Sansom, Owen J.

“…The Adenomatous Polyposis Coli (APC) gene is mutated in the majority of colorectal cancers (CRCs). Loss of APC leads to constitutively active WNT signaling,…”
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Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease by Boulter, Luke, Govaere, Olivier, Bird, Tom G, Radulescu, Sorina, Ramachandran, Prakash, Pellicoro, Antonella, Ridgway, Rachel A, Seo, Sang Soo, Spee, Bart, Van Rooijen, Nico, Sansom, Owen J, Iredale, John P, Lowell, Sally, Roskams, Tania, Forbes, Stuart J

“…Hepatic precursor cells (HPCs) are known to be bipotent and to give rise to both new hepatocytes and cholangiocytes upon acute liver injury. Stuart J. Forbes…”
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TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis by Cheung, Eric C., Athineos, Dimitris, Lee, Pearl, Ridgway, Rachel A., Lambie, Wendy, Nixon, Colin, Strathdee, Douglas, Blyth, Karen, Sansom, Owen J., Vousden, Karen H.

“…Regulation of metabolic pathways plays an important role in controlling cell growth, proliferation, and survival. TIGAR acts as a fructose-2,6-bisphosphatase,…”
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Crypt stem cells as the cells-of-origin of intestinal cancer by van de Wetering, Marc, van Es, Johan H, Sansom, Owen J, Begthel, Harry, van den Born, Maaike, Barker, Nick, Danenberg, Esther, Clarke, Alan R, Clevers, Hans, Ridgway, Rachel A

“…Intestinal cancer is initiated by Wnt-pathway-activating mutations in genes such as adenomatous polyposis coli (APC). As in most cancers, the cell of origin…”
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Hepatic progenitor cells of biliary origin with liver repopulation capacity by Lu, Wei-Yu, Bird, Thomas G., Boulter, Luke, Tsuchiya, Atsunori, Cole, Alicia M., Hay, Trevor, Guest, Rachel V., Wojtacha, Davina, Man, Tak Yung, Mackinnon, Alison, Ridgway, Rachel A., Kendall, Timothy, Williams, Michael J., Jamieson, Thomas, Raven, Alex, Hay, David C., Iredale, John P., Clarke, Alan R., Sansom, Owen J., Forbes, Stuart J.

“…Hepatocytes and cholangiocytes self-renew following liver injury. Following severe injury hepatocytes are increasingly senescent, but whether hepatic…”
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Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer by Gay, David M., Ridgway, Rachel A., Müller, Miryam, Hodder, Michael C., Hedley, Ann, Clark, William, Leach, Joshua D., Jackstadt, Rene, Nixon, Colin, Huels, David J., Campbell, Andrew D., Bird, Thomas G., Sansom, Owen J.

“…Different thresholds of Wnt signalling are thought to drive stem cell maintenance, regeneration, differentiation and cancer. However, the principle that…”
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Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer by Morton, Jennifer P, Timpson, Paul, Karim, Saadia A, Ridgway, Rachel A, Athineos, Dimitris, Doyle, Brendan, Jamieson, Nigel B, Oien, Karin A, Lowy, Andrew M, Brunton, Valerie G, Frame, Margaret C, Evans, T.R. Jeffry, Sansom, Owen J

“…TP53 mutation occurs in 50-75% of human pancreatic ductal adenocarcinomas (PDAC) following an initiating activating mutation in the KRAS gene. These p53…”
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NOTUM from Apc-mutant cells biases clonal competition to initiate cancer by Flanagan, Dustin J., Pentinmikko, Nalle, Luopajärvi, Kalle, Willis, Nicky J., Gilroy, Kathryn, Raven, Alexander P., Mcgarry, Lynn, Englund, Johanna I., Webb, Anna T., Scharaw, Sandra, Nasreddin, Nadia, Hodder, Michael C., Ridgway, Rachel A., Minnee, Emma, Sphyris, Nathalie, Gilchrist, Ella, Najumudeen, Arafath K., Romagnolo, Beatrice, Perret, Christine, Williams, Ann C., Clevers, Hans, Nummela, Pirjo, Lähde, Marianne, Alitalo, Kari, Hietakangas, Ville, Hedley, Ann, Clark, William, Nixon, Colin, Kirschner, Kristina, Jones, E. Yvonne, Ristimäki, Ari, Leedham, Simon J., Fish, Paul V., Vincent, Jean-Paul, Katajisto, Pekka, Sansom, Owen J.

“…The tumour suppressor APC is the most commonly mutated gene in colorectal cancer. Loss of Apc in intestinal stem cells drives the formation of adenomas in mice…”
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WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited by Boulter, Luke, Guest, Rachel V, Kendall, Timothy J, Wilson, David H, Wojtacha, Davina, Robson, Andrew J, Ridgway, Rachel A, Samuel, Kay, Van Rooijen, Nico, Barry, Simon T, Wigmore, Stephen J, Sansom, Owen J, Forbes, Stuart J

“…Cholangiocarcinoma (CC) is typically diagnosed at an advanced stage and is refractory to surgical intervention and chemotherapy. Despite a global increase in…”
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Genomic and taxonomic evaluation of 38 Treponema prophage sequences by Ridgway, Rachel, Lu, Hanshuo, Blower, Tim R, Evans, Nicholas James, Ainsworth, Stuart

“…Despite Spirochetales being a ubiquitous and medically important order of bacteria infecting both humans and animals, there is extremely limited information…”
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mTORC1-mediated translational elongation limits intestinal tumour initiation and growth by Faller, William J., Jackson, Thomas J., Knight, John R. P., Ridgway, Rachel A., Jamieson, Thomas, Karim, Saadia A., Jones, Carolyn, Radulescu, Sorina, Huels, David J., Myant, Kevin B., Dudek, Kate M., Casey, Helen A., Scopelliti, Alessandro, Cordero, Julia B., Vidal, Marcos, Pende, Mario, Ryazanov, Alexey G., Sonenberg, Nahum, Meyuhas, Oded, Hall, Michael N., Bushell, Martin, Willis, Anne E., Sansom, Owen J.

“…The mTORC1 complex has been implicated in tumorigenesis owing partially to its ability to increase protein translation; now, mTORC1 activity in the mouse…”
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Wnt and Src signals converge on YAP‐TEAD to drive intestinal regeneration by Guillermin, Oriane, Angelis, Nikolaos, Sidor, Clara M, Ridgway, Rachel, Baulies, Anna, Kucharska, Anna, Antas, Pedro, Rose, Melissa R, Cordero, Julia, Sansom, Owen, Li, Vivian S W, Thompson, Barry J

“…Wnt signalling induces a gradient of stem/progenitor cell proliferation along the crypt‐villus axis of the intestine, which becomes expanded during intestinal…”
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MmCMS: mouse models’ consensus molecular subtypes of colorectal cancer by Amirkhah, Raheleh, Gilroy, Kathryn, Malla, Sudhir B., Lannagan, Tamsin R. M., Byrne, Ryan M., Fisher, Natalie C., Corry, Shania M., Mohamed, Noha-Ehssan, Naderi-Meshkin, Hojjat, Mills, Megan L., Campbell, Andrew D., Ridgway, Rachel A., Ahmaderaghi, Baharak, Murray, Richard, Llergo, Antoni Berenguer, Sanz-Pamplona, Rebeca, Villanueva, Alberto, Batlle, Eduard, Salazar, Ramon, Lawler, Mark, Sansom, Owen J., Dunne, Philip D.

“…Background Colorectal cancer (CRC) primary tumours are molecularly classified into four consensus molecular subtypes (CMS1–4). Genetically engineered mouse…”
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TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence by Bird, Thomas G, Müller, Miryam, Boulter, Luke, Vincent, David F, Ridgway, Rachel A, Lopez-Guadamillas, Elena, Lu, Wei-Yu, Jamieson, Thomas, Govaere, Olivier, Campbell, Andrew D, Ferreira-Gonzalez, Sofía, Cole, Alicia M, Hay, Trevor, Simpson, Kenneth J, Clark, William, Hedley, Ann, Clarke, Mairi, Gentaz, Pauline, Nixon, Colin, Bryce, Steven, Kiourtis, Christos, Sprangers, Joep, Nibbs, Robert J B, Van Rooijen, Nico, Bartholin, Laurent, McGreal, Steven R, Apte, Udayan, Barry, Simon T, Iredale, John P, Clarke, Alan R, Serrano, Manuel, Roskams, Tania A, Sansom, Owen J, Forbes, Stuart J

“…Liver injury results in rapid regeneration through hepatocyte proliferation and hypertrophy. However, after acute severe injury, such as acetaminophen…”
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Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling by Bird, Thomas G., Lu, Wei-Yu, Boulter, Luke, Gordon-Keylock, Sabrina, Ridgway, Rachel A., Williams, Michael J., Taube, Jessica, Thomas, James A., Wojtacha, Davina, Gambardella, Adriana, Sansom, Owen J., Iredale, John P., Forbes, Stuart J.

“…Tissue progenitor cells are an attractive target for regenerative therapy. In various organs, bone marrow cell (BMC) therapy has shown promising preliminary…”
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ADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival by Kanellos, Georgios, Zhou, Jing, Patel, Hitesh, Ridgway, Rachel A., Huels, David, Gurniak, Christine B., Sandilands, Emma, Carragher, Neil O., Sansom, Owen J., Witke, Walter, Brunton, Valerie G., Frame, Margaret C.

“…Genetic co-depletion of the actin-severing proteins ADF and CFL1 triggers catastrophic loss of adult homeostasis in multiple tissues. There is impaired…”
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Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma by Cammareri, Patrizia, Rose, Aidan M., Vincent, David F., Wang, Jun, Nagano, Ai, Libertini, Silvana, Ridgway, Rachel A., Athineos, Dimitris, Coates, Philip J., McHugh, Angela, Pourreyron, Celine, Dayal, Jasbani H. S., Larsson, Jonas, Weidlich, Simone, Spender, Lindsay C., Sapkota, Gopal P., Purdie, Karin J., Proby, Charlotte M., Harwood, Catherine A., Leigh, Irene M., Clevers, Hans, Barker, Nick, Karlsson, Stefan, Pritchard, Catrin, Marais, Richard, Chelala, Claude, South, Andrew P., Sansom, Owen J., Inman, Gareth J.

“…Melanoma patients treated with oncogenic BRAF inhibitors can develop cutaneous squamous cell carcinoma (cSCC) within weeks of treatment, driven by paradoxical…”
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