Search Results - "Ridgway, Melanie C"

Diverse chemotypes disrupt ion homeostasis in the malaria parasite by Lehane, Adele M., Ridgway, Melanie C., Baker, Eileen, Kirk, Kiaran

“…Summary The antimalarial spiroindolones disrupt Plasmodium falciparum Na+ regulation and induce an alkalinization of the parasite cytosol. It has been proposed…”
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A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin by Qiu, Deyun, Pei, Jinxin V., Rosling, James E. O., Thathy, Vandana, Li, Dongdi, Xue, Yi, Tanner, John D., Penington, Jocelyn Sietsma, Aw, Yi Tong Vincent, Aw, Jessica Yi Han, Xu, Guoyue, Tripathi, Abhai K., Gnadig, Nina F., Yeo, Tomas, Fairhurst, Kate J., Stokes, Barbara H., Murithi, James M., Kümpornsin, Krittikorn, Hasemer, Heath, Dennis, Adelaide S. M., Ridgway, Melanie C., Schmitt, Esther K., Straimer, Judith, Papenfuss, Anthony T., Lee, Marcus C. S., Corry, Ben, Sinnis, Photini, Fidock, David A., van Dooren, Giel G., Kirk, Kiaran, Lehane, Adele M.

“…Diverse compounds target the Plasmodium falciparum Na + pump PfATP4, with cipargamin and (+)-SJ733 the most clinically-advanced. In a recent clinical trial for…”
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Changes in lipid composition during sexual development of the malaria parasite Plasmodium falciparum by Tran, Phuong N, Brown, Simon H J, Rug, Melanie, Ridgway, Melanie C, Mitchell, Todd W, Maier, Alexander G

“…The development of differentiated sexual stages (gametocytes) within human red blood cells is essential for the propagation of the malaria parasite, since only…”
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Novel Method for the Separation of Male and Female Gametocytes of the Malaria Parasite Plasmodium falciparum That Enables Biological and Drug Discovery by Ridgway, Melanie C., Shea, Kwong Sum, Cihalova, Daniela, Maier, Alexander G.

“…We developed a flow-cytometry-based method to separate and collect cocultured male and female Plasmodium falciparum gametocytes responsible for malaria…”
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Human dihydrofolate reductase influences the sensitivity of the malaria parasite Plasmodium falciparum to ketotifen – A cautionary tale in screening transgenic parasites by Tran, Phuong N., Tate, Cameron J., Ridgway, Melanie C., Saliba, Kevin J., Kirk, Kiaran, Maier, Alexander G.

“…Ketotifen has recently been reported to inhibit the growth of both asexual and sexual malaria parasites. A parasite transporter, PfgABCG2, has been implicated…”
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Analysis of sex-specific lipid metabolism of Plasmodium falciparum points to the importance of sphingomyelin for gametocytogenesis by Ridgway, Melanie C, Cihalova, Daniela, Brown, Simon H J, Tran, Phuong, Mitchell, Todd W, Maier, Alexander G

“…Male and female Plasmodium falciparum gametocytes are the parasite lifecycle stage responsible for transmission of malaria from the human host to the mosquito…”
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Biochemical characterization and chemical inhibition of PfATP4-associated Na+-ATPase activity in Plasmodium falciparum membranes by Rosling, James E.O., Ridgway, Melanie C., Summers, Robert L., Kirk, Kiaran, Lehane, Adele M.

“…The antimalarial activity of chemically diverse compounds, including the clinical candidate cipargamin, has been linked to the ATPase PfATP4 in the…”
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Cell Swelling Induced by the Antimalarial KAE609 (Cipargamin) and Other PfATP4-Associated Antimalarials by Dennis, Adelaide S M, Lehane, Adele M, Ridgway, Melanie C, Holleran, John P, Kirk, Kiaran

“…For an increasing number of antimalarial agents identified in high-throughput phenotypic screens, there is evidence that they target PfATP4, a putative Na…”
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Distinct adaptations of a gametocyte ABC transporter to murine and human Plasmodium parasites and its incompatibility in cross-species complementation by Kenthirapalan, Sanketha, Tran, Phuong N., Kooij, Taco W.A., Ridgway, Melanie C., Rauch, Manuel, Brown, Simon H.J., Mitchell, Todd W., Matuschewski, Kai, Maier, Alexander G.

“…[Display omitted] •First bi-directional genetic complementation for Plasmodium falciparum and P. berghei.•Female gametocyte-specific ABCG2 localizes to…”
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Sex-specific Separation of Plasmodium falciparum Gametocyte Populations by Ridgway, Melanie C, Cihalova, Daniela, Maier, Alexander G

“…is a unicellular eukaryotic parasite that causes malaria in humans. The parasite is spread by mosquitoes after ingestion of sexual stage parasites known as…”
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Diverse chemotypes disrupt ion homeostasis in the malaria parasite

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Novel Method for the Separation of Male and Female Gametocytes of the Malaria Parasite italic toggle="yes">Plasmodium falciparum /italic> That Enables Biological and Drug Discovery by Melanie C. Ridgway, Kwong Sum Shea, Daniela Cihalova, Alexander G. Maier

“…ABSTRACT We developed a flow-cytometry-based method to separate and collect cocultured male and female Plasmodium falciparum gametocytes responsible for…”
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