Search Results - "Rider, S. Dean"
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Draft genome of the scabies mite
Published in Parasites & vectors (10-11-2015)“…The disease scabies, caused by the ectoparasitic mite, Sarcoptes scabiei, causes significant morbidity in humans and other mammals worldwide. However, there is…”
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Replication stress at microsatellites causes DNA double-strand breaks and break-induced replication
Published in The Journal of biological chemistry (06-11-2020)“…Short tandemly repeated DNA sequences, termed microsatellites, are abundant in the human genome. These microsatellites exhibit length instability and…”
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3
Allergen homologs in the Euroglyphus maynei draft genome
Published in PloS one (22-08-2017)“…Euroglyphus maynei is a house dust mite commonly found in homes worldwide and is the source of allergens that sensitize and induce allergic reactions in…”
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4
Stable G-quadruplex DNA structures promote replication-dependent genome instability
Published in The Journal of biological chemistry (01-06-2022)“…G-quadruplex (G4)–prone structures are abundant in mammalian genomes, where they have been shown to influence DNA replication, transcription, and genome…”
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Identification of antigenic Sarcoptes scabiei proteins for use in a diagnostic test and of non-antigenic proteins that may be immunomodulatory
Published in PLoS neglected tropical diseases (12-06-2017)“…Scabies, caused by the mite, Sarcoptes scabiei, infects millions of humans, and many wild and domestic mammals. Scabies mites burrow in the lower stratum…”
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Fatty acid binding profile of the liver X receptor α
Published in Journal of lipid research (01-02-2017)“…Liver X receptor (LXR)α is a nuclear receptor that responds to oxysterols and cholesterol overload by stimulating cholesterol efflux, transport, conversion to…”
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Amelioration of Cryptosporidium parvum Infection In Vitro and In Vivo by Targeting Parasite Fatty Acyl-Coenzyme A Synthetases
Published in The Journal of infectious diseases (15-04-2014)“…Background. Cryptosporidium is emerging as 1 of the 4 leading diarrheal pathogens in children in developing countries. Its infections in patients with AIDS can…”
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Are dust mite allergens more abundant and/or more stable than other Dermatophagoides pteronyssinus proteins?
Published in Journal of allergy and clinical immunology (01-03-2017)“…[...]many are outliers in the quartile analysis of the DP transcriptome. Other influences on sensitization include additional environmental exposures,…”
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MAGI-1 PDZ2 Domain Blockade Averts Adenovirus Infection via Enhanced Proteolysis of the Apical Coxsackievirus and Adenovirus Receptor
Published in Journal of virology (10-06-2021)“…Adenoviruses (AdVs) are etiological agents of gastrointestinal, heart, eye, and respiratory tract infections that can be lethal for immunosuppressed people…”
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A Draft Genome of Euroglyphus Maynei with Predicted Allergens
Published in Journal of allergy and clinical immunology (01-02-2017)“…Rationale The house dust mite, Euroglyphus maynei, occurs in homes in some geographical areas of the world and in some homes it is the predominant species…”
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Sarcoptes scabiei: genomics to proteomics to biology
Published in Parasites & vectors (01-07-2016)“…The common scabies mite, Sarcoptes scabiei is a cosmopolitan parasite of humans and other mammals. An annotated genome of Sarcoptes scabiei var. canis has been…”
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12
A Proteomic Analysis of Sarcoptes scabiei (Acari: Sarcoptidae)
Published in Journal of medical entomology (01-05-2016)“…The pruritic skin disease scabies is caused by the burrowing of the itch mite Sarcoptes scabiei (De Geer). It is difficult to diagnose this disease because its…”
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Ligand-Regulated Heterodimerization of Peroxisome Proliferator-Activated Receptor α with Liver X Receptor α
Published in Biochemistry (Easton) (29-04-2014)“…Peroxisome proliferator-activated receptor α (PPARα) and liver X receptor α (LXRα) are members of the nuclear receptor superfamily that function to regulate…”
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The apicomplexan Cryptosporidium parvum possesses a single mitochondrial‐type ferredoxin and ferredoxin:NADP+ reductase system
Published in Protein science (01-11-2010)“…We have successfully expressed recombinant mitochondrial‐type ferredoxin (mtFd) and ferredoxin:NADP+ reductase (mtFNR) from Cryptosporidium parvum and…”
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rearrangement of the Z chromosome topology influences the sex-linked gene display in the European corn borer, Ostrinia nubilalis
Published in Molecular genetics and genomics : MGG (01-07-2011)“…Males are homogametic (ZZ) and females are heterogametic (WZ) with respect to the sex chromosomes in many species of butterflies and moths (insect order…”
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Microsatellite break-induced replication generates highly mutagenized extrachromosomal circular DNAs
Published in NAR cancer (08-06-2024)“…Extrachromosomal circular DNAs (eccDNAs) are produced from all regions of the eucaryotic genome. We used inverse PCR of non-B microsatellites capable of…”
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Divergence between human and murine peroxisome proliferator-activated receptor alpha ligand specificities
Published in Journal of lipid research (01-09-2013)“…Peroxisome proliferator-activated receptor α (PPARα) belongs to the family of ligand-dependent nuclear transcription factors that regulate energy metabolism…”
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An apicomplexan ankyrin-repeat histone deacetylase with relatives in photosynthetic eukaryotes
Published in International journal for parasitology (01-06-2009)“…Cryptosporidium parvum is a member of the Apicomplexa that lacks a plastid and associated nuclear-encoded genes, which has hampered its use in evolutionary…”
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A single amino acid change humanizes long-chain fatty acid binding and activation of mouse peroxisome proliferator-activated receptor α
Published in Journal of molecular graphics & modelling (01-06-2014)“…•Mechanisms underlying divergence in endogenous ligand binding affinities of human and mouse PPARα were examined.•The size and shape of the PPARα ligand…”
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The Protozoan Parasite Cryptosporidium parvum Possesses Two Functionally and Evolutionarily Divergent Replication Protein A Large Subunits
Published in The Journal of biological chemistry (09-09-2005)“…Very little is known about protozoan replication protein A (RPA), a heterotrimeric complex critical for DNA replication and repair. We have discovered that in…”
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