Search Results - "Rideout, Elizabeth J"

Developmental mechanisms of sex differences: from cells to organisms by Mank, Judith E, Rideout, Elizabeth J

“…Male-female differences in many developmental mechanisms lead to the formation of two morphologically and physiologically distinct sexes. Although this is…”
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Control of sexual differentiation and behavior by the doublesex gene in Drosophila melanogaster by Rideout, Elizabeth J, Dornan, Anthony J, Eadie, Suzanne, Neville, Megan C, Goodwin, Stephen F

“…This study defines the roles of the doublesex gene in male and female flies' courtship circuitry and behaviors. Doublesex proteins, which are part of the…”
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The Sex Determination Gene transformer Regulates Male-Female Differences in Drosophila Body Size by Rideout, Elizabeth J, Narsaiya, Marcus S, Grewal, Savraj S

“…Almost all animals show sex differences in body size. For example, in Drosophila, females are larger than males. Although Drosophila is widely used as a model…”
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A role for triglyceride lipase brummer in the regulation of sex differences in Drosophila fat storage and breakdown by Wat, Lianna W, Chao, Charlotte, Bartlett, Rachael, Buchanan, Justin L, Millington, Jason W, Chih, Hui Ju, Chowdhury, Zahid S, Biswas, Puja, Huang, Vivian, Shin, Leah J, Wang, Lin Chuan, Gauthier, Marie-Pierre L, Barone, Maria C, Montooth, Kristi L, Welte, Michael A, Rideout, Elizabeth J

“…Triglycerides are the major form of stored fat in all animals. One important determinant of whole-body fat storage is whether an animal is male or female…”
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Drosophila RNA polymerase III repressor Maf1 controls body size and developmental timing by modulating tRNAiMet synthesis and systemic insulin signaling by Rideout, Elizabeth J, Marshall, Lynne, Grewal, Savraj S

“…The target-of-rapamycin pathway couples nutrient availability with tissue and organismal growth in metazoans. The key effectors underlying this growth are,…”
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Female-biased upregulation of insulin pathway activity mediates the sex difference in Drosophila body size plasticity by Millington, Jason W, Brownrigg, George P, Chao, Charlotte, Sun, Ziwei, Basner-Collins, Paige J, Wat, Lianna W, Hudry, Bruno, Miguel-Aliaga, Irene, Rideout, Elizabeth J

“…Nutrient-dependent body size plasticity differs between the sexes in most species, including mammals. Previous work in showed that body size plasticity was…”
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Sex determination gene transformer regulates the male-female difference in Drosophila fat storage via the adipokinetic hormone pathway by Wat, Lianna W, Chowdhury, Zahid S, Millington, Jason W, Biswas, Puja, Rideout, Elizabeth J

“…Sex differences in whole-body fat storage exist in many species. For example, females store more fat than males. Yet, the mechanisms underlying this sex…”
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The Sex-Determination Genes fruitless and doublesex Specify a Neural Substrate Required for Courtship Song by Rideout, Elizabeth J., Billeter, Jean-Christophe, Goodwin, Stephen F.

“…Courtship song is a critical component of male courtship behavior in Drosophila, making the female more receptive to copulation and communicating…”
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Sex differences in islet stress responses support female β cell resilience by Brownrigg, George P., Xia, Yi Han, Chu, Chieh Min Jamie, Wang, Su, Chao, Charlotte, Zhang, Jiashuo Aaron, Skovsø, Søs, Panzhinskiy, Evgeniy, Hu, Xiaoke, Johnson, James D., Rideout, Elizabeth J.

“…Pancreatic β cells play a key role in maintaining glucose homeostasis; dysfunction of this critical cell type causes type 2 diabetes (T2D). Emerging evidence…”
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TIF-IA-dependent regulation of ribosome synthesis in drosophila muscle is required to maintain systemic insulin signaling and larval growth by Ghosh, Abhishek, Rideout, Elizabeth J, Grewal, Savraj S

“…The conserved TOR kinase signaling network links nutrient availability to cell, tissue and body growth in animals. One important growth-regulatory target of…”
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Consideration of sex as a biological variable in diabetes research across twenty years by Cherian, Celena M, Reeves, Hayley R, De Silva, Duneesha, Tsao, Serena, Marshall, Katie E, Rideout, Elizabeth J

“…Sex differences exist in the risk of developing type 1 and type 2 diabetes, and in the risk of developing diabetes-associated complications. Sex differences in…”
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Genetic manipulation of insulin/insulin-like growth factor signaling pathway activity has sex-biased effects on Drosophila body size by Millington, Jason W, Brownrigg, George P, Basner-Collins, Paige J, Sun, Ziwei, Rideout, Elizabeth J

“…Abstract In Drosophila raised in nutrient-rich conditions, female body size is approximately 30% larger than male body size due to an increased rate of growth…”
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Control of Male Sexual Behavior in Drosophila by the Sex Determination Pathway by Billeter, Jean-Christophe, Rideout, Elizabeth J., Dornan, Anthony J., Goodwin, Stephen F.

“…Understanding how genes influence behavior, including sexuality, is one of biology's greatest challenges. Much of the recent progress in understanding how…”
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Effects of hyperinsulinemia on pancreatic cancer development and the immune microenvironment revealed through single-cell transcriptomics by Zhang, Anni M Y, Chu, Ken H, Daly, Brian F, Ruiter, Titine, Dou, Yan, Yang, Jenny C C, de Winter, Twan J J, Chhuor, Justin, Wang, Su, Flibotte, Stephane, Zhao, Yiwei Bernie, Hu, Xiaoke, Li, Hong, Rideout, Elizabeth J, Schaeffer, David F, Johnson, James D, Kopp, Janel L

“…Hyperinsulinemia is independently associated with increased risk and mortality of pancreatic cancer. We recently reported that genetically reduced insulin…”
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Sexual Dimorphism: Ecdysone Modulates Sex Differences in the Gut by Millington, Jason W, Rideout, Elizabeth J

“…Sex differences in the Drosophila gut were discovered only recently. Recent work significantly extends our understanding of how steroid hormones specify these…”
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Nutrient/TOR-dependent regulation of RNA polymerase III controls tissue and organismal growth in Drosophila by Marshall, Lynne, Rideout, Elizabeth J, Grewal, Savraj S

“…The nutrient/target‐of‐rapamycin (TOR) pathway has emerged as a key regulator of tissue and organismal growth in metazoans. The signalling components of the…”
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Characterization of two distinct binding modes between syntaxin 4 and Munc18c by Aran, Veronica, Brandie, Fiona M, Boyd, Alasdair R, Kantidakis, Theodoros, Rideout, Elizabeth J, Kelly, Sharon M, Gould, Gwyn W, Bryant, Nia J

“…Interaction of SM (Sec1/Munc18) proteins with their cognate syntaxins represents an important regulatory mechanism of SNARE (soluble N-ethylmaleimide-sensitive…”
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Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and inflammation by Zhang, Anni M Y, Xia, Yi Han, Lin, Jeffrey S H, Chu, Ken H, Wang, Wei Chuan K, Ruiter, Titine J J, Yang, Jenny C C, Chen, Nan, Chhuor, Justin, Patil, Shilpa, Cen, Haoning Howard, Rideout, Elizabeth J, Richard, Vincent R, Schaeffer, David F, Zahedi, Rene P, Borchers, Christoph H, Johnson, James D, Kopp, Janel L

“…The rising pancreatic cancer incidence due to obesity and type 2 diabetes is closely tied to hyperinsulinemia, an independent cancer risk factor. Previous…”
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Sex differences in Drosophila development and physiology by Millington, Jason W, Rideout, Elizabeth J

“…•Sex differences in intestinal stem cell proliferation impact gut homeostasis.•Sex-specific regulation of cell signaling pathways affects growth and body…”
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A low-sugar diet enhances Drosophila body size in males and females via sex-specific mechanisms by Millington, Jason W, Biswas, Puja, Chao, Charlotte, Xia, Yi Han, Wat, Lianna W, Brownrigg, George P, Sun, Ziwei, Basner-Collins, Paige J, Klein Geltink, Ramon I, Rideout, Elizabeth J

“…In Drosophila, changes to dietary protein elicit different body size responses between the sexes. Whether these differential body size effects extend to other…”
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