Search Results - "Ride, Jonathan P"

Cortisone-reductase deficiency associated with heterozygous mutations in 11β-hydroxysteroid dehydrogenase type 1 by Lawson, Alexander J, Walker, Elizabeth A, Lavery, Gareth G, Bujalska, Iwona J, Hughes, Beverly, Arlt, Wiebke, Stewart, Paul M, Ride, Jonathan P

“…In peripheral target tissues, levels of active glucocorticoid hormones are controlled by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), a dimeric enzyme…”
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Lack of functional and expression homology between human and mouse aldo-keto reductase 1C enzymes: implications for modelling human cancers by Veliça, Pedro, Davies, Nicholas J, Rocha, Pedro P, Schrewe, Heinrich, Ride, Jonathan P, Bunce, Chris M

“…Over recent years, enzymes of the aldo-keto reductase (AKR) 1C subfamily have been implicated in the progression of prostate, breast, endometrial and leukemic…”
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AKR1C Isoforms Represent a Novel Cellular Target for Jasmonates alongside Their Mitochondrial-Mediated Effects by DAVIES, Nicholas J, HAYDEN, Rachel E, SIMPSON, Paul J, BIRTWISTLE, Jane, MAYER, Katarina, RIDE, Jonathan P, BUNCE, Chris M

“…Members of the aldo-keto reductase (AKR) superfamily, particularly the AKR1C subfamily, are emerging as important mediators of the pathology of cancer. Agents…”
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11 beta -Hydroxysteroid Dehydrogenase Type 1 Regulation by Intracellular Glucose 6-Phosphate Provides Evidence for a Novel Link between Glucose Metabolism and Hypothalamo-Pituitary-Adrenal Axis Function by Walker, Elizabeth A, Ahmed, Adeeba, Lavery, Gareth G, Tomlinson, Jeremy W, Kim, So Youn, Cooper, Mark S, Ride, Jonathan P, Hughes, Beverly A, Shackleton, Cedric HL, McKiernan, Patrick, Elias, Elwyn, Chou, Janice Y, Stewart, Paul M

“…Microsomal glucose-6-phosphatase- alpha (G6Pase- alpha ) and glucose 6-phosphate transporter (G6PT) work together to increase blood glucose concentrations by…”
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The aldo-keto reductase AKR1C3 is a novel suppressor of cell differentiation that provides a plausible target for the non-cyclooxygenase-dependent antineoplastic actions of nonsteroidal anti-inflammatory drugs by DESMOND, Julian C, MOUNTFORD, Joanne C, DRAYSON, Mark T, WALKER, Elizabeth A, HEWISON, Martin, RIDE, Jonathan P, LUONG, Quang T, HAYDEN, Rachel E, VANIN, Elio F, BUNCE, Christopher M

“…We and others have demonstrated expression of the aldo-keto reductase AKR1C3 in myeloid leukemia cell lines and that inhibitors of the enzyme, including…”
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Mutations of key hydrophobic surface residues of 11β‐hydroxysteroid dehydrogenase type 1 increase solubility and monodispersity in a bacterial expression system by Lawson, Alexander J., Walker, Elizabeth A., White, Scott A., Dafforn, Timothy R., Stewart, Paul M., Ride, Jonathan P.

“…11β‐Hydroxysteroid dehydrogenase type 1 (11β‐HSD1) is a key enzyme in the conversion of cortisone to the functional glucocorticoid hormone cortisol. This…”
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The aldo-keto reductase AKR1C3 contributes to 7,12-dimethylbenz(a)anthracene-3,4-dihydrodiol mediated oxidative DNA damage in myeloid cells: implications for leukemogenesis by Birtwistle, Jane, Hayden, Rachel E, Khanim, Farhat L, Green, Richard M, Pearce, Claire, Davies, Nicholas J, Wake, Naomi, Schrewe, Heiner, Ride, Jonathan P, Chipman, James K, Bunce, Chris M

“…The aldo-keto reductase AKR1C3, has been shown to regulate myelopoiesis via its ability to metabolise prostaglandin D2 (PGD2). Other studies have demonstrated…”
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Erratum to: Lack of functional and expression homology between human and mouse aldo-keto reductase 1C enzymes: implications for modelling human cancers by Veliça, Pedro, Davies, Nicholas J, Rocha, Pedro P, Schrewe, Heinrich, Ride, Jonathan P, Bunce, Chris M

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Correction: Lack of functional and expression homology between human and mouse aldo-keto reductase 1C enzymes: implications for modelling human cancers by Veliça, Pedro, Davies, Nicholas J, Rocha, Pedro P, Schrewe, Heinrich, Ride, Jonathan P, Bunce, Chris M

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11β-Hydroxysteroid Dehydrogenase Type 1 Regulation by Intracellular Glucose 6-Phosphate Provides Evidence for a Novel Link between Glucose Metabolism and Hypothalamo-Pituitary-Adrenal Axis Function by Walker, Elizabeth A., Ahmed, Adeeba, Lavery, Gareth G., Tomlinson, Jeremy W., Kim, So Youn, Cooper, Mark S., Ride, Jonathan P., Hughes, Beverly A., Shackleton, Cedric H.L., McKiernan, Patrick, Elias, Elwyn, Chou, Janice Y., Stewart, Paul M.

“…Microsomal glucose-6-phosphatase-α (G6Pase-α) and glucose 6-phosphate transporter (G6PT) work together to increase blood glucose concentrations by performing…”
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Cortisone-reductase deficiency associated with heterozygous mutations in 11[Beta]-hydroxysteroid dehydrogenase type 1 by Lawson, Alexander J, Walker, Elizabeth A, Lavery, Gareth G, Bujalska, Iwona J, Hughes, Beverly, Arlt, Wiebke, Stewart, Paul M, Ride, Jonathan P

“…In peripheral target tissues, levels of active glucocorticoid hormones are controlled by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), a dimeric enzyme…”
Get full text

Cortisone-reductase deficiency associated with heterozygous mutations in 11β-hydroxysteroid dehydrogenase type 1 by Lawson, Alexander J, Walker, Elizabeth A, Lavery, Gareth G, Bujalska, Iwona J, Hughes, Beverly, Arlt, Wiebke, Stewart, Paul M, Ride, Jonathan P

“…In peripheral target tissues, levels of active glucocorticoid hormones are controlled by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), a dimeric enzyme…”
Get full text

Mutations of key hydrophobic surface residues of 11[beta]-hydroxysteroid dehydrogenase type 1 increase solubility and monodispersity in a bacterial expression system by Lawson, Alexander J, Walker, Elizabeth A, White, Scott A, Dafforn, Timothy R, Stewart, Paul M, Ride, Jonathan P

“…11[beta]-Hydroxysteroid dehydrogenase type 1 (11[beta]-HSD1) is a key enzyme in the conversion of cortisone to the functional glucocorticoid hormone cortisol…”
Get full text

11β-Hydroxysteroid Dehydrogenase Type 1 Regulation by Intracellular Glucose 6-Phosphate Provides Evidence for a Novel Link between Glucose Metabolism and Hypothalamo-Pituitary-Adrenal Axis Function by Elizabeth A. Walker, Adeeba Ahmed, Gareth G. Lavery, Jeremy W. Tomlinson, So Youn Kim, Mark S. Cooper, Jonathan P. Ride, Beverly A. Hughes, Cedric H. L. Shackleton, Patrick McKiernan, Elwyn Elias, Janice Y. Chou, Paul M. Stewart

“…Microsomal glucose-6-phosphatase-α (G6Pase-α) and glucose 6-phosphate transporter (G6PT) work together to increase blood glucose concentrations by performing…”
Get full text

11beta-Hydroxysteroid Dehydrogenase Type 1 Regulation by Intracellular Glucose 6-Phosphate Provides Evidence for a Novel Link between Glucose Metabolism and Hypothalamo-Pituitary-Adrenal Axis Function by Walker, Elizabeth A, Ahmed, Adeeba, Lavery, Gareth G, Tomlinson, Jeremy W, Kim, So Youn, Cooper, Mark S, Ride, Jonathan P, Hughes, Beverly A, Shackleton, Cedric H L, McKiernan, Patrick, Elias, Elwyn, Chou, Janice Y, Stewart, Paul M

“…Microsomal glucose-6-phosphatase-alpha (G6Pase-alpha) and glucose 6-phosphate transporter (G6PT) work together to increase blood glucose concentrations by…”
Get full text

Cortisone-reductase deficiency associated with heterozygous mutations in 11beta-hydroxysteroid dehydrogenase type 1 by Lawson, Alexander J, Walker, Elizabeth A, Lavery, Gareth G, Bujalska, Iwona J, Hughes, Beverly, Arlt, Wiebke, Stewart, Paul M, Ride, Jonathan P

“…In peripheral target tissues, levels of active glucocorticoid hormones are controlled by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), a dimeric enzyme…”
Get full text