Search Results - "Riddle, Dawn M"

Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons by Guo, Jing L., Covell, Dustin J., Daniels, Joshua P., Iba, Michiyo, Stieber, Anna, Zhang, Bin, Riddle, Dawn M., Kwong, Linda K., Xu, Yan, Trojanowski, John Q., Lee, Virginia M.Y.

“…Many neurodegenerative diseases are characterized by the accumulation of insoluble protein aggregates, including neurofibrillary tangles comprised of tau…”
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Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death by Volpicelli-Daley, Laura A., Luk, Kelvin C., Patel, Tapan P., Tanik, Selcuk A., Riddle, Dawn M., Stieber, Anna, Meaney, David F., Trojanowski, John Q., Lee, Virginia M.-Y.

“…Inclusions composed of α-synuclein (α-syn), i.e., Lewy bodies (LBs) and Lewy neurites (LNs), define synucleinopathies including Parkinson's disease (PD) and…”
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Human tau pathology transmits glial tau aggregates in the absence of neuronal tau by Narasimhan, Sneha, Changolkar, Lakshmi, Riddle, Dawn M, Kats, Alexandra, Stieber, Anna, Weitzman, Sarah A, Zhang, Bin, Li, Zhiyong, Roberson, Erik D, Trojanowski, John Q, Lee, Virginia M Y

“…Tauopathies are characterized by abnormal accumulation of tau protein in neurons and glia. In Alzheimer's disease (AD), tau aggregates in neurons, while in…”
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Characterization of novel conformation-selective α-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease by Henderson, Michael X., Covell, Dustin J., Chung, Charlotte Hiu-Yan, Pitkin, Rose M., Sandler, Raizel M., Decker, Samantha C., Riddle, Dawn M., Zhang, Bin, Gathagan, Ronald J., James, Michael J., Trojanowski, John Q., Brunden, Kurt R., Lee, Virginia M.Y., Luk, Kelvin C.

“…Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are progressive neurodegenerative diseases for which there is no disease-modifying treatment. PD…”
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Unbiased Proteomics of Early Lewy Body Formation Model Implicates Active Microtubule Affinity-Regulating Kinases (MARKs) in Synucleinopathies by Henderson, Michael X, Chung, Charlotte Hiu-Yan, Riddle, Dawn M, Zhang, Bin, Gathagan, Ronald J, Seeholzer, Steven H, Trojanowski, John Q, Lee, Virginia M Y

“…Parkinson's disease (PD) patients progressively accumulate intracytoplasmic inclusions formed by misfolded α-synuclein known as Lewy bodies (LBs). LBs also…”
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Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimer's disease by Gibbons, Garrett S, Kim, Soo-Jung, Wu, Qihui, Riddle, Dawn M, Leight, Susan N, Changolkar, Lakshmi, Xu, Hong, Meymand, Emily S, O'Reilly, Mia, Zhang, Bin, Brunden, Kurt R, Trojanowski, John Q, Lee, Virginia M Y

“…The spread of tau pathology in Alzheimer's disease (AD) is mediated by cell-to-cell transmission of pathological tau seeds released from neurons that, upon…”
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Inhibition of CK2 mitigates Alzheimer's tau pathology by preventing NR2B synaptic mislocalization by Marshall, Courtney A, McBride, Jennifer D, Changolkar, Lakshmi, Riddle, Dawn M, Trojanowski, John Q, Lee, Virginia M-Y

“…Alzheimer's disease (AD) is a neurodegenerative disorder that exhibits pathological changes in both tau and synaptic function. AD patients display increases in…”
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Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology by Bassil, Fares, Brown, Hannah J., Pattabhiraman, Shankar, Iwasyk, Joe E., Maghames, Chantal M., Meymand, Emily S., Cox, Timothy O., Riddle, Dawn M., Zhang, Bin, Trojanowski, John Q., Lee, Virginia M.-Y.

“…Studies have shown an overlap of Aβ plaques, tau tangles, and α-synuclein (α-syn) pathologies in the brains of Alzheimer’s disease (AD) and Parkinson’s disease…”
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α-Synuclein (αSyn) Preformed Fibrils Induce Endogenous αSyn Aggregation, Compromise Synaptic Activity and Enhance Synapse Loss in Cultured Excitatory Hippocampal Neurons by Wu, Qihui, Takano, Hajime, Riddle, Dawn M, Trojanowski, John Q, Coulter, Douglas A, Lee, Virginia M-Y

“…Synucleinopathies are characterized by the accumulation of insoluble α-synuclein (αSyn). To test whether αSyn aggregates modulate synaptic activity, we used a…”
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Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult by Henderson, Michael X., Sedor, Samantha, McGeary, Ian, Cornblath, Eli J., Peng, Chao, Riddle, Dawn M., Li, Howard L., Zhang, Bin, Brown, Hannah J., Olufemi, Modupe F., Bassett, Danielle S., Trojanowski, John Q., Lee, Virginia M.Y.

“…Mutations in the GBA1 gene are the most common genetic risk factor for Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). GBA1 encodes the lysosomal…”
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Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes by Volpicelli-Daley, Laura A, Gamble, Karen L, Schultheiss, Christine E, Riddle, Dawn M, West, Andrew B, Lee, Virginia M-Y

“…Aggregates of α-synuclein (α-syn) accumulate in neurons in Parkinson's disease and other synucleinopathies. These inclusions predominantly localize to axons…”
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Differential α-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity by Luna, Esteban, Decker, Samantha C., Riddle, Dawn M., Caputo, Anna, Zhang, Bin, Cole, Tracy, Caswell, Carrie, Xie, Sharon X., Lee, Virginia M. Y., Luk, Kelvin C.

“…The accumulation of misfolded α-synuclein (aSyn) and neuron loss define several neurodegenerative disorders including Parkinson’s disease (PD) and dementia…”
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Detection of Alzheimer Disease (AD)-Specific Tau Pathology in AD and NonAD Tauopathies by Immunohistochemistry With Novel Conformation-Selective Tau Antibodies by Gibbons, Garrett S, Banks, Rachel A, Kim, Bumjin, Changolkar, Lakshmi, Riddle, Dawn M, Leight, Susan N, Irwin, David J, Trojanowski, John Q, Lee, Virginia M Y

“…Abstract Aggregation of tau into fibrillar structures within the CNS is a pathological hallmark of a clinically heterogeneous set of neurodegenerative diseases…”
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Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology by Bassil, Fares, Brown, Hannah J, Pattabhiraman, Shankar, Iwasyk, Joe E, Maghames, Chantal M, Meymand, Emily S, Cox, Timothy O, Riddle, Dawn M, Zhang, Bin, Trojanowski, John Q, Lee, Virginia M-Y

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In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics by Xu, Hong, O’Reilly, Mia, Gibbons, Garrett S., Changolkar, Lakshmi, McBride, Jennifer D., Riddle, Dawn M., Zhang, Bin, Stieber, Anna, Nirschl, Jeffrey, Kim, Soo-Jung, Hoxha, Kevt-her, Brunden, Kurt R., Schellenberg, Gerard D., Trojanowski, John Q., Lee, Virginia M.-Y.

“…The microtubule-associated protein tau (tau) forms hyperphosphorylated aggregates in the brains of tauopathy patients that can be pathologically and…”
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GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils by Gibbons, Garrett S, Banks, Rachel A, Kim, Bumjin, Xu, Hong, Changolkar, Lakshmi, Leight, Susan N, Riddle, Dawn M, Li, Chi, Gathagan, Ronald J, Brown, Hannah J, Zhang, Bin, Trojanowski, John Q, Lee, Virginia M-Y

“…Neurodegenerative proteinopathies characterized by intracellular aggregates of tau proteins, termed tauopathies, include Alzheimer's disease (AD),…”
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Novel monoclonal antibodies to normal and pathologically altered human TDP-43 proteins by Kwong, Linda K, Irwin, David J, Walker, Adam K, Xu, Yan, Riddle, Dawn M, Trojanowski, John Q, Lee, Virginia M Y

“…The RNA/DNA-binding protein, TDP-43, is the key component of ubiquitinated inclusions characteristic of amyotrophic lateral sclerosis (ALS) and the majority of…”
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Exogenous [alpha]-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death by Volpicelli-Daley, Laura A, Luk, Kelvin C, Patel, Tapan P, Tanik, Selcuk A, Riddle, Dawn M, Stieber, Anna, Meaney, David F, Trojanowski, John Q, Lee, Virginia M-Y

“…Inclusions composed of α-synuclein (α-syn), i.e., Lewy bodies (LBs) and Lewy neurites (LNs), define synucleinopathies including Parkinson's disease (PD) and…”
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APC +/- alters colonic fibroblast proteome in FAP by Patel, Bhavinkumar B, Li, Xin-Ming, Dixon, Maketa P, Blagoi, Elena L, Nicolas, Emmanuelle, Seeholzer, Steven H, Cheng, David, He, Yin A, Coudry, Renata A, Howard, Sharon D, Riddle, Dawn M, Cooper, Harry C, Boman, Bruce M, Conrad, Peggy, Crowell, James A, Bellacosa, Alfonso, Knudson, Alfred, Yeung, Anthony T, Kopelovich, Levy

“…Here we compared the proteomes of primary fibroblast cultures derived from morphologically normal colonic mucosa of familial adenomatous polyposis (FAP)…”
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Differential [alpha]-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity by Luna, Esteban, Decker, Samantha C, Riddle, Dawn M, Caputo, Anna, Zhang, Bin, Cole, Tracy, Caswell, Carrie

“…The accumulation of misfolded [alpha]-synuclein (aSyn) and neuron loss define several neurodegenerative disorders including Parkinson's disease (PD) and…”
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