Search Results - "Rico, Alice"

Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF by Shao, Wenlin, Mishina, Yuji M, Feng, Yun, Caponigro, Giordano, Cooke, Vesselina G, Rivera, Stacy, Wang, Yingyun, Shen, Fang, Korn, Joshua M, Mathews Griner, Lesley A, Nishiguchi, Gisele, Rico, Alice, Tellew, John, Haling, Jacob R, Aversa, Robert, Polyakov, Valery, Zang, Richard, Hekmat-Nejad, Mohammad, Amiri, Payman, Singh, Mallika, Keen, Nicholas, Dillon, Michael P, Lees, Emma, Ramurthy, Savithri, Sellers, William R, Stuart, Darrin D

“…Resistance to the RAF inhibitor vemurafenib arises commonly in melanomas driven by the activated BRAF oncogene. Here, we report antitumor properties of RAF709,…”
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Discovery of 2-pyrimidyl-5-amidothiophenes as potent inhibitors for AKT: Synthesis and SAR studies by Lin, Xiaodong, Murray, Jeremy M., Rico, Alice C., Wang, Michael X., Chu, Daniel T., Zhou, Yasheen, Rosario, Merci Del, Kaufman, Susan, Ma, Sylvia, Fang, Eric, Crawford, Kenneth, Jefferson, A.B.

“…A series of 2-pyrimidyl-5-amidothiophenes has been synthesized and evaluated for AKT inhibition. Compound 2aa is a potent AKT inhibitor and showed cellular…”
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Synthesis and Antibacterial Activity of Novel C12 Vinyl Ketolides by Burger, Matthew T, Lin, Xiaodong, Chu, Daniel T, Hiebert, Christy, Rico, Alice C, Seid, Mehran, Carroll, Georgia L, Barker, Lynn, Huh, Kay, Langhorne, Mike, Shawar, Ribhi, Kidney, Jolene, Young, Kelly, Anderson, Scott, Desai, Manoj C, Plattner, Jacob J

“…A novel series of C12 vinyl erythromycin derivatives have been discovered which exhibit in vitro and in vivo potency against key respiratory pathogens. The C12…”
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Synthesis and antibacterial activity of C12 des-methyl ketolides by XIAODONG LIN, RICO, Alice C, CHU, Daniel T, CARROLL, Georgia L, BARKER, Lynn, SHAWAR, Ribhi, DESAI, Manoj C, PLATTNER, Jacob J

“…Synthesis of C(12) des-methyl ketolide is developed featuring an intramolecular epoxide formation/elimination process to establish the C(12) stereocenter…”
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Antihydrophobic Solvent Effects:  An Experimental Probe for the Hydrophobic Contribution to Enzyme−Inhibitor Binding by Bartlett, Paul A, Yusuff, Naeem, Rico, Alice C, Lindvall, Mika K

“…The hydrophobic component to the binding affinities of one acyclic phosphinate (4) and three macrocyclic phosphonamidate inhibitors (1−3) to the zinc peptidase…”
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Design and Discovery of N‑(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic by Ramurthy, Savithri, Taft, Benjamin R, Aversa, Robert J, Barsanti, Paul A, Burger, Matthew T, Lou, Yan, Nishiguchi, Gisele A, Rico, Alice, Setti, Lina, Smith, Aaron, Subramanian, Sharadha, Tamez, Victoriano, Tanner, Huw, Wan, Lifeng, Hu, Cheng, Appleton, Brent A, Mamo, Mulugeta, Tandeske, Laura, Tellew, John E, Huang, Shenlin, Yue, Qin, Chaudhary, Apurva, Tian, Hung, Iyer, Raman, Hassan, A. Quamrul, Mathews Griner, Lesley A, La Bonte, Laura R, Cooke, Vesselina G, Van Abbema, Anne, Merritt, Hanne, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Mishina, Yuji, Wang, Yingyun, Haling, Jacob R, Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Sellers, William R, Lees, Emma, Shao, Wenlin, Dillon, Michael P, Stuart, Darrin D

“…Direct pharmacological inhibition of RAS has remained elusive, and efforts to target CRAF have been challenging due to the complex nature of RAF signaling,…”
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Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria by Skepper, Colin K, Armstrong, Duncan, Balibar, Carl J, Bauer, Daniel, Bellamacina, Cornelia, Benton, Bret M, Bussiere, Dirksen, De Pascale, Gianfranco, De Vicente, Javier, Dean, Charles R, Dhumale, Bhavesh, Fisher, L. Mark, Fuller, John, Fulsunder, Mangesh, Holder, Lauren M, Hu, Cheng, Kantariya, Bhavin, Lapointe, Guillaume, Leeds, Jennifer A, Li, Xiaolin, Lu, Peichao, Lvov, Anatoli, Ma, Sylvia, Madhavan, Shravanthi, Malekar, Swapnil, McKenney, David, Mergo, Wosenu, Metzger, Louis, Moser, Heinz E, Mutnick, Daniel, Noeske, Jonas, Osborne, Colin, Patel, Ashish, Patel, Darshit, Patel, Tushar, Prajapati, Krunal, Prosen, Katherine R, Reck, Folkert, Richie, Daryl L, Rico, Alice, Sanderson, Mark R, Satasia, Shailesh, Sawyer, William S, Selvarajah, Jogitha, Shah, Nirav, Shanghavi, Kartik, Shu, Wei, Thompson, Katherine V, Traebert, Martin, Vala, Anand, Vala, Lakhan, Veselkov, Dennis A, Vo, Jason, Wang, Michael, Widya, Marcella, Williams, Sarah L, Xu, Yongjin, Yue, Qin, Zang, Richard, Zhou, Bo, Rivkin, Alexey

“…Since their discovery over 5 decades ago, quinolone antibiotics have found enormous success as broad spectrum agents that exert their activity through dual…”
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Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline by Lee, Patrick S, Lapointe, Guillaume, Madera, Ann Marie, Simmons, Robert L, Xu, Wenjian, Yifru, Aregahegn, Tjandra, Meiliana, Karur, Subramanian, Rico, Alice, Thompson, Katherine, Bojkovic, Jade, Xie, Lili, Uehara, Kyoko, Liu, Amy, Shu, Wei, Bellamacina, Cornelia, McKenney, David, Morris, Laura, Tonn, George R, Osborne, Colin, Benton, Bret M, McDowell, Laura, Fu, Jiping, Sweeney, Zachary K

“…This report summarizes the identification and synthesis of novel LpxC inhibitors aided by computational methods that leveraged numerous crystal structures…”
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Synthesis and Structure–Activity Relationship of Tetra-Substituted Cyclohexyl Diol Inhibitors of Proviral Insertion of Moloney Virus (PIM) Kinases by Han, Wooseok, Ding, Yu, Chen, Zheng, Langowski, John L, Bellamacina, Cornelia, Rico, Alice, Nishiguchi, Gisele A, Lan, Jiong, Atallah, Gordana, Lindvall, Mika, Lin, Song, Zang, Richard, Feucht, Paul, Zavorotinskaya, Tatiana, Dai, Yumin, Garcia, Pablo, Burger, Matthew T

“…Overexpression of PIM 1, 2, and 3 kinases is frequently observed in many malignancies. Previously, we discovered a potent and selective pan-PIM kinase…”
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Design and Discovery of N‑(2-Methyl-5′-morpholino-6′-((tetrahydro‑2H‑pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers by Nishiguchi, Gisele A, Rico, Alice, Tanner, Huw, Aversa, Robert J, Taft, Benjamin R, Subramanian, Sharadha, Setti, Lina, Burger, Matthew T, Wan, Lifeng, Tamez, Victoriano, Smith, Aaron, Lou, Yan, Barsanti, Paul A, Appleton, Brent A, Mamo, Mulugeta, Tandeske, Laura, Dix, Ina, Tellew, John E, Huang, Shenlin, Mathews Griner, Lesley A, Cooke, Vesselina G, Van Abbema, Anne, Merritt, Hanne, Ma, Sylvia, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Wang, Yingyun, Haling, Jacob R, Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Jansen, Johanna M, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Lees, Emma, Shao, Wenlin, Stuart, Darrin D, Dillon, Michael P, Ramurthy, Savithri

“…RAS oncogenes have been implicated in >30% of human cancers, all representing high unmet medical need. The exquisite dependency on CRAF kinase in KRAS mutant…”
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Abstract DDT01-04: Pharmacological profile and anti-tumor properties of LXH254, a highly selective RAF kinase inhibitor by Stuart, Darrin D., Shao, Wenlin, Mishina, Yuji, Feng, Yun, Caponigro, Giordano, Cooke, Vesselina G., Rivera, Stacey, Shen, Fang, Korn, Joshua, Griner, Lesley A. Mathews, Nishiguchi, Giselle, Taft, Benjamin, Wan, Lifeng, Subramanian, Sharadha, Lou, Yan, Setti, Lina, Burger, Matthew, Tamez, Victor, Rico, Alice, Aversa, Robert, Tellew, John, Haling, Jacob R., Polyakov, Valery, Lambert, Amy, Zang, Richard, Abbema, Ann Van, Hekmat-Nejad, Mohamad, Amiri, Payman, Singh, Mallika, Keen, Nicholas, Dillon, Michael P., Lees, Emma, Sellers, William R., Ramurthy, Savithri

“…Abstract The mitogen-activated protein kinase (MAPK) signaling pathway is frequently activated in human cancers due to genetic alterations that can occur at…”
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Abstract 330: Development of a highly selective BCRAF kinase inhibitor that exhibits antitumor activities in RAS and BRAF mutant tumors with minimal paradoxical activation by Shao, Wenlin, Mishina, Yuji, Feng, Yun, Caponigro, Giordano, Ramurthy, Savithri, Cooke, Vesselina, Griner, Lesley, Nishiguchi, Gisele, Rico, Alice, Taft, Ben, Burger, Matthew, Tanner, Huw, Polyakov, Valery, Appleton, Brent, Tellew, John, Zang, Richard, Hekmat-Nejad, Mohammad, Amiri, Payman, Singh, Mallika, Stuart, Darrin

“…The mitogen-activated protein kinase (MAPK) signaling pathway is frequently activated in human cancers due to genetic alterations that can occur at multiple…”
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Abstract 330: Development of a highly selective B/CRAF kinase inhibitor that exhibits antitumor activities in RAS and BRAF mutant tumors with minimal paradoxical activation by Shao, Wenlin, Mishina, Yuji, Feng, Yun, Caponigro, Giordano, Ramurthy, Savithri, Cooke, Vesselina, Griner, Lesley, Nishiguchi, Gisele, Rico, Alice, Taft, Ben, Burger, Matthew, Tanner, Huw, Polyakov, Valery, Appleton, Brent, Tellew, John, Zang, Richard, Hekmat-Nejad, Mohammad, Amiri, Payman, Singh, Mallika, Stuart, Darrin

“…Abstract The mitogen-activated protein kinase (MAPK) signaling pathway is frequently activated in human cancers due to genetic alterations that can occur at…”
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Design, Structure–Activity Relationship, and in Vivo Characterization of the Development Candidate NVP-HSP990 by McBride, Christopher M, Levine, Barry, Xia, Yi, Bellamacina, Cornelia, Machajewski, Timothy, Gao, Zhenhai, Renhowe, Paul, Antonios-McCrea, William, Barsanti, Paul, Brinner, Kristin, Costales, Abran, Doughan, Brandon, Lin, Xiaodong, Louie, Alicia, McKenna, Maureen, Mendenhall, Kris, Poon, Daniel, Rico, Alice, Wang, Michael, Williams, Teresa E, Abrams, Tinya, Fong, Susan, Hendrickson, Thomas, Lei, Dachuan, Lin, Julie, Menezes, Daniel, Pryer, Nancy, Taverna, Pietro, Xu, Yongjin, Zhou, Yasheen, Shafer, Cynthia M

“…Utilizing structure-based drug design, a novel dihydropyridopyrimidinone series which exhibited potent Hsp90 inhibition, good pharmacokinetics upon oral…”
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Synthesis and antibacterial activity of C 12 des-methyl ketolides by Lin, Xiaodong, Rico, Alice C., Chu, Daniel T., Carroll, Georgia L., Barker, Lynn, Shawar, Ribhi, Desai, Manoj C., Plattner, Jacob J.

“…Synthesis of C 12 des-methyl ketolides is developed featuring an intramolecular epoxide formation/elimination process to establish the C 12 stereocenter. These…”
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Synthesis and Antibacterial Activity of Novel C 12 Vinyl Ketolides by Burger, Matthew T., Lin, Xiaodong, Chu, Daniel T., Hiebert, Christy, Rico, Alice C., Seid, Mehran, Carroll, Georgia L., Barker, Lynn, Huh, Kay, Langhorne, Mike, Shawar, Ribhi, Kidney, Jolene, Young, Kelly, Anderson, Scott, Desai, Manoj C., Plattner, Jacob J.

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Synthesis and antibacterial activity of C sub(12) des-methyl ketolides by Lin, Xiaodong, Rico, Alice C, Chu, Daniel T, Carroll, Georgia L, Barker, Lynn, Shawar, Ribhi, Desai, Manoj C, Plattner, Jacob J

“…Synthesis of C sub(12) des-methyl ketolide is developed featuring an intramolecular epoxide formation/elimination process to establish the C sub(12)…”
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