Search Results - "Rickert, Emily L"
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1
Synthesis and Characterization of Fluorescent 4-Hydroxytamoxifen Conjugates with Unique Antiestrogenic Properties
Published in Bioconjugate chemistry (19-05-2010)“…Membrane receptors for steroid hormones are currently a subject of considerable debate. One approach to selectively target these putative receptors has been to…”
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Journal Article -
2
Dissecting rapid estrogen signaling with conjugates
Published in Steroids (01-08-2012)“…[Display omitted] ► Estrogen conjugates are used to study localization of rapid responses. ► Conjugates are useful, but they should be used very carefully. ►…”
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Journal Article -
3
Characterization of molecular and structural determinants of selective estrogen receptor downregulators
Published in Breast cancer research and treatment (01-05-2007)“…Antiestrogens used for breast cancer therapy can be categorized into two classes that differ in their effect on estrogen receptor (ER) alpha stability. The…”
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Journal Article -
4
Synthesis and evaluation of 3- and 7-substituted geranylgeranyl pyrophosphate analogs
Published in Bioorganic & medicinal chemistry (15-03-2008)“…Protein prenyl transferases have been a focus of anti-cancer drug discovery in recent years due to their roles in post-translational modification of small GTP…”
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Journal Article -
5
Synthesis and Characterization of Bioactive Tamoxifen-Conjugated Polymers
Published in Biomacromolecules (01-11-2007)“…Macromolecular conjugates of tamoxifen could perhaps be used to circumvent some of the limitations of the extensively used breast cancer drug. To test the…”
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Journal Article -
6
Effect of caloric restriction on the expression of the Sirtuin Proteins
Published in The FASEB journal (01-04-2012)“…Abstract only SirT1 is a deacetylase whose expression and activity increases during times of caloric restriction (CR). CR has been implicated lifespan…”
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Journal Article -
7
Synthesis and Characterizaton of Fluorescent 4-Hydroxytamoxifen Conjugates with Unique Antiestrogenic Properties
Published in Bioconjugate chemistry (19-05-2010)“…Membrane receptors for steroid hormones are currently a subject of considerable debate. One approach to selectively target these putative receptors has been to…”
Get full text
Journal Article -
8
Synthesis and Characterization of Bioactive Tamoxifen-Conjugated Polymers
Published in Biomacromolecules (01-01-2007)“…Macromolecular conjugates of tamoxifen could perhaps be used to circumvent some of the limitations of the extensively used breast cancer drug. To test the…”
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Journal Article -
9
Synthesis and biological characterization of anti-estrogen conjugates
Published 01-01-2008“…The overall function of estrogen receptor modulators and their role in the signaling of estrogen receptors through non-classical pathways is poorly understood…”
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Dissertation