Search Results - "Richter, Wiltrud"

Regulation of WNT5A and WNT11 during MSC in vitro chondrogenesis: WNT inhibition lowers BMP and hedgehog activity, and reduces hypertrophy by Diederichs, Solvig, Tonnier, Veronika, März, Melanie, Dreher, Simon I., Geisbüsch, Andreas, Richter, Wiltrud

“…Re-directing mesenchymal stromal cell (MSC) chondrogenesis towards a non-hypertrophic articular chondrocyte-(AC)-like phenotype is important for improving…”
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Proliferation as a requirement for in vitro chondrogenesis of human mesenchymal stem cells by Dexheimer, Verena, Frank, Sebastian, Richter, Wiltrud

“…During embryonic cartilage development, proliferation and differentiation are tightly linked with a transient cell cycle arrest observed during determination…”
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Reduced reactivation from dormancy but maintained lineage choice of human mesenchymal stem cells with donor age by Dexheimer, Verena, Mueller, Sebastian, Braatz, Frank, Richter, Wiltrud

“…Mesenchymal stem cells (MSC) are promising for cell-based regeneration therapies but up to date it is still controversial whether their function is maintained…”
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Impact of c-MYC expression on proliferation, differentiation, and risk of neoplastic transformation of human mesenchymal stromal cells by Melnik, Svitlana, Werth, Nadine, Boeuf, Stephane, Hahn, Eva-Maria, Gotterbarm, Tobias, Anton, Martina, Richter, Wiltrud

“…Mesenchymal stromal cells isolated from bone marrow (MSC) represent an attractive source of adult stem cells for regenerative medicine. However, thorough…”
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Role of PTHrP(1-34) Pulse Frequency Versus Pulse Duration to Enhance Mesenchymal Stromal Cell Chondrogenesis by Fischer, Jennifer, Ortel, Marlen, Hagmann, Sebastien, Hoeflich, Andreas, Richter, Wiltrud

“…Generation of phenotypically stable, articular chondrocytes from mesenchymal stromal cells (MSCs) is still an unaccomplished task, with formation of abundant,…”
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Comparison of mesenchymal stem cells from bone marrow and adipose tissue for bone regeneration in a critical size defect of the sheep tibia and the influence of platelet-rich plasma by Niemeyer, Philipp, Fechner, Katharina, Milz, Stefan, Richter, Wiltrud, Suedkamp, Norbert P, Mehlhorn, Alexander T, Pearce, Simon, Kasten, Philip

“…Abstract Aim of the present study was to compare the osteogenic potential of bone marrow derived mesenchymal stem cells (BMSC) and adipose-tissue derived stem…”
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The Role of Extracellular Matrix Expression, ERK1/2 Signaling and Cell Cohesiveness for Cartilage Yield from iPSCs by Buchert, Justyna, Diederichs, Solvig, Kreuser, Ursula, Merle, Christian, Richter, Wiltrud

“…Current therapies involving chondrocytes or mesenchymal stromal cells (MSCs) remain inefficient in restoring cartilage properties upon injury. The induced…”
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Calcification or dedifferentiation: Requirement to lock mesenchymal stem cells in a desired differentiation stage by Dickhut, Andrea, Pelttari, Karoliina, Janicki, Patricia, Wagner, Wolfgang, Eckstein, Volker, Egermann, Marcus, Richter, Wiltrud

“…A current challenge in mesenchymal stem cell (MSC)‐based cartilage repair is to solve donor and tissue‐dependent variability of MSC cultures and to prevent…”
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Application of VEGFA and FGF-9 enhances angiogenesis, osteogenesis and bone remodeling in type 2 diabetic long bone regeneration by Wallner, Christoph, Schira, Jessica, Wagner, Johannes Maximilian, Schulte, Matthias, Fischer, Sebastian, Hirsch, Tobias, Richter, Wiltrud, Abraham, Stephanie, Kneser, Ulrich, Lehnhardt, Marcus, Behr, Björn

“…Although bone regeneration is typically a reliable process, type 2 diabetes is associated with impaired or delayed healing processes. In addition,…”
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Heparan Sulfate Deficiency in Cartilage: Enhanced BMP-Sensitivity, Proteoglycan Production and an Anti-Apoptotic Expression Signature after Loading by Gerstner, Matthias, Severmann, Ann-Christine, Chasan, Safak, Vortkamp, Andrea, Richter, Wiltrud

“…Osteoarthritis (OA) represents one major cause of disability worldwide still evading efficient pharmacological or cellular therapies. Severe degeneration of…”
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Mesenchymal stromal cell implantation for stimulation of long bone healing aggravates Staphylococcus aureus induced osteomyelitis by Seebach, Elisabeth, Holschbach, Jeannine, Buchta, Nicole, Bitsch, Rudi Georg, Kleinschmidt, Kerstin, Richter, Wiltrud

“…[Display omitted] Large bone defects requiring long-term osteosynthetic stabilization or repeated surgeries show a considerable rate of infection. Mesenchymal…”
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NFκB inhibition to lift the mechano-competence of mesenchymal stromal cell-derived neocartilage toward articular chondrocyte levels by Lückgen, Janine, Raqué, Elisabeth, Reiner, Tobias, Diederichs, Solvig, Richter, Wiltrud

“…Fully functional regeneration of skeletal defects by multipotent progenitor cells requires that differentiating cells gain the specific mechano-competence…”
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Mesenchymal stromal cell chondrogenesis under ALK1/2/3-specific BMP inhibition: a revision of the prohypertrophic signalling network concept by Diederichs, Solvig, Dreher, Simon I, Nüesch, Sarah Anna, Schmidt, Sven, Merle, Christian, Richter, Wiltrud

“…In vitro chondrogenesis of mesenchymal stromal cells (MSCs) driven by the essential chondro-inducer transforming growth factor (TGF)-β is instable and yields…”
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Chondral Differentiation of Induced Pluripotent Stem Cells Without Progression Into the Endochondral Pathway by Diederichs, Solvig, Klampfleuthner, Felicia A. M., Moradi, Babak, Richter, Wiltrud

“…A major problem with chondrocytes derived in vitro from stem cells is undesired hypertrophic degeneration, to which articular chondrocytes (ACs) are resistant…”
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Enhanced reconstruction of long bone architecture by a growth factor mutant combining positive features of GDF-5 and BMP-2 by Kleinschmidt, Kerstin, Ploeger, Frank, Nickel, Joachim, Glockenmeier, Julia, Kunz, Pierre, Richter, Wiltrud

“…Abstract Non healing bone defects remain a worldwide health problem and still only few osteoinductive growth factors are available for clinical use in bone…”
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Vascular Endothelial Growth Factor Gene‐Activated Matrix (VEGF165‐GAM) Enhances Osteogenesis and Angiogenesis in Large Segmental Bone Defects by Geiger, Florian, Bertram, Helge, Berger, Irina, Lorenz, Helga, Wall, Olga, Eckhardt, Christina, Simank, Hans‐Georg, Richter, Wiltrud

“…Healing of fractures is dependent on vascularization of bone, which is in turn promoted by VEGF. It was shown that 0.1 and 1 mg of pVEGF165‐GAM led to a…”
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Different culture media affect growth characteristics, surface marker distribution and chondrogenic differentiation of human bone marrow-derived mesenchymal stromal cells by Hagmann, Sebastien, Moradi, Babak, Frank, Sebastian, Dreher, Thomas, Kämmerer, Peer Wolfgang, Richter, Wiltrud, Gotterbarm, Tobias

“…Bone marrow-derived mesenchymal stromal cells (BM-MSCs) play an important role in modern tissue engineering, while distinct variations of culture media…”
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Treatment of Focal Cartilage Defects in Minipigs with Zonal Chondrocyte/Mesenchymal Progenitor Cell Constructs by Bothe, Friederike, Deubel, Anne-Kathrin, Hesse, Eliane, Lotz, Benedict, Groll, Jürgen, Werner, Carsten, Richter, Wiltrud, Hagmann, Sebastien

“…Despite advances in cartilage repair strategies, treatment of focal chondral lesions remains an important challenge to prevent osteoarthritis. Articular…”
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Inverse Regulation of Cartilage Neogenesis at Physiologically Relevant Calcium Conditions by Human Articular Chondrocytes and Mesenchymal Stromal Cells by Hammersen, Tim, Buchert, Justyna, Zietzschmann, Severin, Diederichs, Solvig, Richter, Wiltrud

“…Elaborate bioreactor cultivation or expensive growth factor supplementation can enhance extracellular matrix production in engineered neocartilage to provide…”
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Initial WNT/β-Catenin Activation Enhanced Mesoderm Commitment, Extracellular Matrix Expression, Cell Aggregation and Cartilage Tissue Yield From Induced Pluripotent Stem Cells by Kreuser, Ursula, Buchert, Justyna, Haase, Alexandra, Richter, Wiltrud, Diederichs, Solvig

“…Mesodermal differentiation of induced pluripotent stem cells (iPSCs) in vitro and subsequent specification into mesodermal derivatives like chondrocytes is…”
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