Search Results - "Richter, Hans GF"

Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia & diabetes by Richter, Hans G.F., Benson, Gregory M., Blum, Denise, Chaput, Evelyne, Feng, Song, Gardes, Christophe, Grether, Uwe, Hartman, Peter, Kuhn, Bernd, Martin, Rainer E., Plancher, Jean-Marc, Rudolph, Markus G., Schuler, Franz, Taylor, Sven, Bleicher, Konrad H.

“…Herein we describe the synthesis and structure activity relationship of a new class of FXR agonists identified from a high-throughput screening campaign…”
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Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties by Richter, Hans G.F., Benson, G.M., Bleicher, K.H., Blum, D., Chaput, E., Clemann, N., Feng, S., Gardes, C., Grether, U., Hartman, P., Kuhn, B., Martin, R.E., Plancher, J.-M., Rudolph, M.G., Schuler, F., Taylor, S.

“…Structure-guided lead optimization of recently described benzimidazolyl acetamides addressed the key liabilities of the previous lead compound 1. These efforts…”
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Synthesis and biological evaluation of novel hexahydro- pyrido[3',2':4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT sub(2C) receptor agonists by Richter, Hans GF, Adams, DR, Benardeau, A, Bickerdike, MJ, Bentley, J M, Blench, T J, Cliffe, IA, Dourish, C, Hebeisen, P, Kennett, G A, Knight, A R, Malcolm, C S, Mattei, P, Misra, A, Mizrahi, J, Monck, NJT, Plancher, J-M, Roever, S, Roffey, JRA, Taylor, S, Vickers, S P

“…Further lead optimization efforts on previously described 1,2,3,4,10,10a- hexahydro-1H-pyrazino[1,2-a]indoles led to the new class of…”
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