Search Results - "Richter, Günther H.S."

EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation by Richter, Günther H.S, Plehm, Stephanie, Fasan, Annette, Rössler, Sabine, Unland, Rebekka, Bennani-Baiti, Idriss M, Hotfilder, Marc, Löwel, Diana, von Luettichau, Irene, Mossbrugger, Ilona, Quintanilla-Martinez, Leticia, Kovar, Heinrich, Staege, Martin S, Müller-Tidow, Carsten, Burdach, Stefan

“…Ewing tumors (ET) are highly malignant, localized in bone or soft tissue, and are molecularly defined by ews/ets translocations. DNA microarray analysis…”
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Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma by Hensel, Tim, Giorgi, Chiara, Schmidt, Oxana, Calzada-Wack, Julia, Neff, Frauke, Buch, Thorsten, Niggli, Felix K, Schäfer, Beat W, Burdach, Stefan, Richter, Günther H S

“…Ewing sarcomas (ES) are highly malignant bone or soft tissue tumors. Genetically, ES are defined by balanced chromosomal EWS/ETS translocations, which give…”
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DKK2 Mediates Osteolysis, Invasiveness, and Metastatic Spread in Ewing Sarcoma by HAUER, Kristina, CALZADA-WACK, Julia, RICHTER, Günther H. S, STEIGER, Katja, GRUNEWALD, Thomas G. P, BAUMHOER, Daniel, PLEHM, Stephanie, BUCH, Thorsten, DA COSTA, Olivia Prazeres, ESPOSITO, Irene, BURDACH, Stefan

“…Ewing sarcoma, an osteolytic malignancy that mainly affects children and young adults, is characterized by early metastasis to lung and bone. In this study, we…”
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Combined Inhibition of Epigenetic Readers and Transcription Initiation Targets the EWS-ETS Transcriptional Program in Ewing Sarcoma by Richter, Günther H S, Hensel, Tim, Schmidt, Oxana, Saratov, Vadim, von Heyking, Kristina, Becker-Dettling, Fiona, Prexler, Carolin, Yen, Hsi-Yu, Steiger, Katja, Fulda, Simone, Dirksen, Uta, Weichert, Wilko, Wang, Shudong, Burdach, Stefan, Schäfer, Beat W

“…Previously, we used inhibitors blocking BET bromodomain binding proteins (BRDs) in Ewing sarcoma (EwS) and observed that long term treatment resulted in the…”
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The endochondral bone protein CHM1 sustains an undifferentiated, invasive phenotype, promoting lung metastasis in Ewing sarcoma by Heyking, Kristina, Calzada‐Wack, Julia, Göllner, Stefanie, Neff, Frauke, Schmidt, Oxana, Hensel, Tim, Schirmer, David, Fasan, Annette, Esposito, Irene, Müller‐Tidow, Carsten, Sorensen, Poul H., Burdach, Stefan, Richter, Günther H. S.

“…Ewing sarcomas (ES) are highly malignant, osteolytic bone or soft tissue tumors, which are characterized by EWS–ETS translocations and early metastasis to lung…”
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Epigenetic maintenance of stemness and malignancy in peripheral neuroectodermal tumors by EZH2 by Burdach, Stefan, Plehm, Stephanie, Unland, Rebekka, Borkhardt, Arndt, Staege, Martin S., Müller-Tidow, Carsten, Richter, Günther H.S.

“…Chromatin modifications are increasingly recognized as a key mechanism in cancer. The histone methyl-transferase Enhancer of Zeste, Drosophila, Homolog 2…”
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MondoA is highly overexpressed in acute lymphoblastic leukemia cells and modulates their metabolism, differentiation and survival by Wernicke, Caroline M, Richter, Günther H.S, Beinvogl, Beate C, Plehm, Stephanie, Schlitter, Anna M, Bandapalli, Obul R, Prazeres da Costa, Olivia, Hattenhorst, Uwe E, Volkmer, Ines, Staege, Martin S, Esposito, Irene, Burdach, Stefan, Grunewald, Thomas G.P

“…Abstract Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. To identify novel candidates for targeted therapy, we performed a…”
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Novel BCOR-MAML3 and ZC3H7B-BCOR Gene Fusions in Undifferentiated Small Blue Round Cell Sarcomas by Specht, Katja, Zhang, Lei, Sung, Yun-Shao, Nucci, Marisa, Dry, Sarah, Vaiyapuri, Sumathi, Richter, Gunther H.S, Fletcher, Christopher D.M, Antonescu, Cristina R

“…Small blue round cell tumors (SBRCTs) are a heterogenous group of tumors that are difficult to diagnose because of overlapping morphologic,…”
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The ENCCA-WP7/EuroSarc/EEC/PROVABES/EURAMOS 3rd European Bone Sarcoma Networking Meeting/Joint Workshop of EU Bone Sarcoma Translational Research Networks; Vienna, Austria, September 24-25, 2015. Workshop Report by Kager, Leo, Whelan, Jeremy, Dirksen, Uta, Hassan, Bass, Anninga, Jakob, Bennister, Lindsey, Bovée, Judith V M G, Brennan, Bernadette, Broto, Javier M, Brugières, Laurence, Cleton-Jansen, Anne-Marie, Copland, Christopher, Dutour, Aurélie, Fagioli, Franca, Ferrari, Stefano, Fiocco, Marta, Fleuren, Emmy, Gaspar, Nathalie, Gelderblom, Hans, Gerrand, Craig, Gerß, Joachim, Gonzato, Ornella, van der Graaf, Winette, Hecker-Nolting, Stefanie, Herrero-Martín, David, Klco-Brosius, Stephanie, Kovar, Heinrich, Ladenstein, Ruth, Lancia, Carlo, LeDeley, Marie-Cecile, McCabe, Martin G, Metzler, Markus, Myklebost, Ola, Nathrath, Michaela, Picci, Piero, Potratz, Jenny, Redini, Françoise, Richter, Günther H S, Reinke, Denise, Rutkowski, Piotr, Scotlandi, Katia, Strauss, Sandra, Thomas, David, Tirado, Oscar M, Tirode, Franck, Vassal, Gilles, Bielack, Stefan S

“…This report summarizes the results of the 3rd Joint ENCCA-WP7, EuroSarc, EEC, PROVABES, and EURAMOS European Bone Sarcoma Network Meeting, which was held at…”
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Distinct transcriptional signature and immunoprofile of CIC-DUX4 fusion-positive round cell tumors compared to EWSR1-rearranged ewing sarcomas: Further evidence toward distinct pathologic entities by Specht, Katja, Sung, Yun-Shao, Zhang, Lei, Richter, Günther H. S., Fletcher, Christopher D., Antonescu, Cristina R.

“…Round cell sarcomas harboring CIC‐DUX4 fusions have recently been described as highly aggressive soft tissue tumors of children and young adults. Due to…”
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On pinning-depinning and microkink-flow in solid state dewetting: Insights by in-situ ESEM on Al thin films by Hieke, Stefan Werner, Willinger, Marc-Georg, Wang, Zhu-Jun, Richter, Gunther, Chatain, Dominique, Dehm, Gerhard, Scheu, Christina

“…The dynamics of solid state dewetting phenomena of a 50 nm thick, mazed bicrystalline Al film on single crystalline α-Al2O3 (sapphire) substrates was studied…”
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Deep Sequencing in Conjunction with Expression and Functional Analyses Reveals Activation of FGFR1 in Ewing Sarcoma by Agelopoulos, Konstantin, Richter, Günther H S, Schmidt, Eva, Dirksen, Uta, von Heyking, Kristina, Moser, Benjamin, Klein, Hans-Ulrich, Kontny, Udo, Dugas, Martin, Poos, Kathrin, Korsching, Eberhard, Buch, Thorsten, Weckesser, Matthias, Schulze, Isabell, Besoke, Regina, Witten, Anika, Stoll, Monika, Köhler, Gabriele, Hartmann, Wolfgang, Wardelmann, Eva, Rossig, Claudia, Baumhoer, Daniel, Jürgens, Heribert, Burdach, Stefan, Berdel, Wolfgang E, Müller-Tidow, Carsten

“…A low mutation rate seems to be a general feature of pediatric cancers, in particular in oncofusion gene-driven tumors. Genetically, Ewing sarcoma is defined…”
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Class I histone deacetylases (HDAC) critically contribute to Ewing sarcoma pathogenesis by Schmidt, Oxana, Nehls, Nadja, Prexler, Carolin, von Heyking, Kristina, Groll, Tanja, Pardon, Katharina, Garcia, Heathcliff D, Hensel, Tim, Gürgen, Dennis, Henssen, Anton G, Eggert, Angelika, Steiger, Katja, Burdach, Stefan, Richter, Günther H S

“…Histone acetylation and deacetylation seem processes involved in the pathogenesis of Ewing sarcoma (EwS). Here histone deacetylases (HDAC) class I were…”
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Abstract PR13: Targeting p-TEFb as well as the EWS-ETS-specific transcriptional program in Ewing sarcoma synergistically blocks tumor growth by Hensel, Tim, Giorgi, Chiara, Schmidt, Oxana, Yen, Hsi-Yu, Steiger, Katja, Fulda, Simone, Niggli, Felix K., Weigert, Wilko, Wang, Shudong, Schäfer, Beat W., Burdach, Stefan, Richter, Günther H.S.

“…Introduction: Ewing sarcomas (EwS) are highly malignant bone or soft tissue tumors. Genetically, EwS are defined by balanced chromosomal EWSR1/ETS…”
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MondoA drives malignancy in B-ALL through enhanced adaptation to metabolic stress by Sipol, Alexandra, Hameister, Erik, Xue, Busheng, Hofstetter, Julia, Barenboim, Maxim, Öllinger, Rupert, Jain, Gaurav, Prexler, Carolin, Rubio, Rebeca Alba, Baldauf, Michaela C., Franchina, Davide G., Petry, Andreas, Schmäh, Juliane, Thiel, Uwe, Görlach, Agnes, Cario, Gunnar, Brenner, Dirk, Richter, Günther H.S., Grünewald, Thomas G.P., Rad, Roland, Wolf, Elmar, Ruland, Jürgen, Sorensen, Poul H., Burdach, Stefan E.G.

“…Cancer cells are in most instances characterized by rapid proliferation and uncontrolled cell division. Hence, they must adapt to proliferation-induced…”
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STEAP1 is associated with the invasive and oxidative stress phenotype of Ewing tumors by Grunewald, Thomas G P, Diebold, Isabel, Esposito, Irene, Plehm, Stephanie, Hauer, Kristina, Thiel, Uwe, da Silva-Buttkus, Patricia, Neff, Frauke, Unland, Rebekka, Müller-Tidow, Carsten, Zobywalski, Colette, Lohrig, Katharina, Lewandrowski, Urs, Sickmann, Albert, Prazeres da Costa, Olivia, Görlach, Agnes, Cossarizza, Andrea, Butt, Elke, Richter, Günther H S, Burdach, Stefan

“…Ewing tumors comprise the second most common type of bone-associated cancer in children and are characterized by oncogenic EWS/FLI1 fusion proteins and early…”
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Abstract B03: The endochondral bone protein CHM1 sustains an undifferentiated, invasive phenotype promoting lung metastasis in Ewing sarcoma by Heyking, Kristina von, Calzada-Wack, Julia, Göllner, Stefanie, Schmidt, Oxana, Hensel, Tim, Schirmer, David, Fasan, Annette, Müller-Tidow, Carsten, Sorensen, Poul, Burdach, Stefan, Richter, Günther H.S.

“…Background: Ewing sarcoma (ES), an osteogenic malignancy that mainly affects children and young adults, is characterized by early metastasis to lung and bone…”
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Matrix mineralization controls gene expression in osteoblastic cells by Wischmann, Johannes, Lenze, Florian, Thiel, Antonia, Bookbinder, Sakina, Querido, William, Schmidt, Oxana, Burgkart, Rainer, von Eisenhart-Rothe, Rüdiger, Richter, Günther H.S., Pleshko, Nancy, Mayer-Kuckuk, Philipp

“…Osteoblasts are adherent cells, and under physiological conditions they attach to both mineralized and non-mineralized osseous surfaces. However, how exactly…”
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Abstract 1421: Overexpression of the pro-glycolytic transcription factor MondoA enhances malignant potential of ALL in vivo by Sipol, Alexandra A., Richter, Günther H.S., Wernicke, Caroline M., Grunewald, Thomas G.P., Burdach, Stefan

“…Introduction. Most cancer cells use glycolysis for energy production regardless of whether they are under normoxic or hypoxic condition (Koppenol et al.,…”
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First identification of Ewing's sarcoma-derived extracellular vesicles and exploration of their biological and potential diagnostic implications by Miller, Isabella V., Raposo, Graca, Welsch, Ulrich, Prazeres da Costa, Olivia, Thiel, Uwe, Lebar, Maria, Maurer, Martina, Bender, Hans-Ulrich, von Luettichau, Irene, Richter, Günther H. S., Burdach, Stefan, Grunewald, Thomas G. P.

“…Background Information Exosomes are small RNA‐ and protein‐containing extracellular vesicles (EVs) that are thought to mediate hetero‐ and homotypic…”
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