Search Results - "Richmond, Graham"

AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer by Cross, Darren A E, Ashton, Susan E, Ghiorghiu, Serban, Eberlein, Cath, Nebhan, Caroline A, Spitzler, Paula J, Orme, Jonathon P, Finlay, M Raymond V, Ward, Richard A, Mellor, Martine J, Hughes, Gareth, Rahi, Amar, Jacobs, Vivien N, Red Brewer, Monica, Ichihara, Eiki, Sun, Jing, Jin, Hailing, Ballard, Peter, Al-Kadhimi, Katherine, Rowlinson, Rachel, Klinowska, Teresa, Richmond, Graham H P, Cantarini, Mireille, Kim, Dong-Wan, Ranson, Malcolm R, Pao, William

“…First-generation EGFR tyrosine kinase inhibitors (EGFR TKI) provide significant clinical benefit in patients with advanced EGFR-mutant (EGFRm(+)) non-small…”
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AZD2171 : A highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer by WEDGE, Stephen R, KENDREW, Jane, CHESTER, Rosemary, JACKSON, Janet A, BOFFEY, Sarah J, KILBURN, Lyndsey L, BARNETT, Sharon, RICHMOND, Graham H. P, WADSWORTH, Peter F, WALKER, Mike, BIGLEY, Alison L, TAYLOR, Sian T, HENNEQUIN, Laurent F, COOPER, Lee, BECK, Sarah, JÜRGENSMEIER, Juliane M, OGILVIE, Donald J, VALENTINE, Paula J, BARRY, Simon T, BRAVE, Sandra R, SMITH, Neil R, JAMES, Neil H, DUKES, Michael, CURWEN, Jon O

“…Inhibition of vascular endothelial growth factor-A (VEGF) signaling is a promising therapeutic approach that aims to stabilize the progression of solid…”
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PDGFR Inhibition Results in Pericyte Depletion and Hemorrhage into the Corpus Luteum of the Rat Ovary by Hall, Anthony P., Ashton, Susan, Horner, Judith, Wilson, Zena, Reens, Jaimini, Richmond, Graham H. P., Barry, Simon T., Wedge, Steve R.

“…The growth plate, ovary, adrenal gland, and rodent incisor tooth are sentinel organs for antiangiogenic effects since they respond reliably, quantitatively,…”
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ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration by WEDGE, Stephen R, OGILVIE, Donald J, GRAHAM, George A, HUGHES, Gareth D, THOMAS, Andrew P, STOKES, Elaine S. E, CURRY, Brenda, RICHMOND, Graham H. P, WADSWORTH, Peter F, BIGLEY, Alison L, HENNEQUIN, Laurent F, DUKES, Michael, KENDREW, Jane, CHESTER, Rosemary, JACKSON, Janet A, BOFFEY, Sarah J, VALENTINE, Paula J, CURWEN, Jon O, MUSGROVE, Helen L

“…ZD6474 [N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine]is a potent, p.o. active, low molecular weight inhibitor of…”
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Development of in-airway laser absorption spectroscopy for respiratory based measurements of cardiac output by Smith, Nicholas M. J., Couper, John, Richmond, Graham, Sandhu, Dominic, Hancock, Gus, Robbins, Peter A., Ritchie, Grant A. D.

“…Respiratory approaches to determining cardiac output in humans are securely rooted in mass balance and therefore potentially highly accurate. To address…”
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Portable Device for Measuring Breath Acetone Based on Sample Preconcentration and Cavity Enhanced Spectroscopy by Blaikie, Thomas P. J, Couper, John, Hancock, Gus, Hurst, Philip L, Peverall, Robert, Richmond, Graham, Ritchie, Grant A. D, Taylor, David, Valentine, Kevin

“…A portable and compact device is demonstrated for measuring acetone in breath samples. The device features a 7 cm long high finesse optical cavity as an…”
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Inhibition of Vascular Endothelial Growth Factor-A Signaling Induces Hypertension: Examining the Effect of Cediranib (Recentin; AZD2171) Treatment on Blood Pressure in Rat and the Use of Concomitant Antihypertensive Therapy by Curwen, Jon O, Musgrove, Helen L, Kendrew, Jane, Richmond, Graham H P, Ogilvie, Donald J, Wedge, Stephen R

“…Purpose: Inhibition of vascular endothelial growth factor-A (VEGF) signaling is a key therapeutic approach in oncology given the role of VEGF in angiogenesis…”
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The Lognormal Lung: A new approach to quantifying lung inhomogeneity in COPD by Smith, Nicholas M. J., Magor-Elliott, Snapper R. M., Fullerton, Christopher J., Couper, John H., Richmond, Graham, Hancock, Gus, Ritchie, Grant A. D., Robbins, Peter A., Talbot, Nick P., Petousi, Nayia

“…Early diagnosis and disease phenotyping in COPD are currently limited by the use of spirometry, which may remain normal despite significant small-airways…”
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Novel measure of lung function for assessing disease activity in asthma by Smith, Nicholas M J, Couper, John, Fullerton, Christopher J, Richmond, Graham, Talbot, Nick P, Hancock, Gus, Pavord, Ian, Ritchie, Grant A D, Robbins, Peter A, Petousi, Nayia

“…IntroductionIn asthma, lung function measures are often discordant with clinical features such as disease activity or control.MethodsWe investigated a novel…”
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ZD4190 : An orally active inhibitor of vascular endothelial growth factor signaling with broad-spectrum antitumor efficacy by WEDGE, S. R, OGILVIE, D. J, WADSWORTH, P. F, DUKES, M, KENDREW, J, CURWEN, J. O, HENNEQUIN, L. F, THOMAS, A. P, STOKES, E. S. E, CURRY, B, RICHMOND, G. H. P

“…There is evidence that vascular endothelial growth factor (VEGF) contributes to solid tumor growth through the promotion of both angiogenesis and tumor…”
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Frequency modulated circular dichroism spectroscopy: application to ICN photolysis by Hancock, Gus, Richmond, Graham, Ritchie, Grant A.D., Taylor, Sarah, Costen, Matthew L., Hall, Gregory E.

“…CN photofragments produced in the 248 nm photolysis of ICN are characterised by frequency-modulated absorption spectroscopy in the red A 2 Π ← X 2 Σ + system…”
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Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor by Finlay, M. Raymond V, Anderton, Mark, Ashton, Susan, Ballard, Peter, Bethel, Paul A, Box, Matthew R, Bradbury, Robert H, Brown, Simon J, Butterworth, Sam, Campbell, Andrew, Chorley, Christopher, Colclough, Nicola, Cross, Darren A. E, Currie, Gordon S, Grist, Matthew, Hassall, Lorraine, Hill, George B, James, Daniel, James, Michael, Kemmitt, Paul, Klinowska, Teresa, Lamont, Gillian, Lamont, Scott G, Martin, Nathaniel, McFarland, Heather L, Mellor, Martine J, Orme, Jonathon P, Perkins, David, Perkins, Paula, Richmond, Graham, Smith, Peter, Ward, Richard A, Waring, Michael J, Whittaker, David, Wells, Stuart, Wrigley, Gail L

“…Epidermal growth factor receptor (EGFR) inhibitors have been used clinically in the treatment of non-small-cell lung cancer (NSCLC) patients harboring…”
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AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models by Weir, Hazel M, Bradbury, Robert H, Lawson, Mandy, Rabow, Alfred A, Buttar, David, Callis, Rowena J, Curwen, Jon O, de Almeida, Camila, Ballard, Peter, Hulse, Michael, Donald, Craig S, Feron, Lyman J L, Karoutchi, Galith, MacFaul, Philip, Moss, Thomas, Norman, Richard A, Pearson, Stuart E, Tonge, Michael, Davies, Gareth, Walker, Graeme E, Wilson, Zena, Rowlinson, Rachel, Powell, Steve, Sadler, Claire, Richmond, Graham, Ladd, Brendon, Pazolli, Ermira, Mazzola, Anne Marie, D'Cruz, Celina, De Savi, Chris

“…Fulvestrant is an estrogen receptor (ER) antagonist administered to breast cancer patients by monthly intramuscular injection. Given its present limitations of…”
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Inhibition of fat accumulation, lipid dysmetabolism, cardiac inflammation, and improved nitric oxide signalling mediate the protective effects of lycopene against cardio-metabolic disorder in obese female rats by Ugwor, Emmanuel Ifeanyichukwu, Ugbaja, Regina Ngozi, James, Adewale Segun, Dosumu, Oluwatosin Adebisi, Thomas, Funmilola Clara, Ezenandu, Emmanuel Obinna, Graham, Richmond Emeka

“…Obesity, hallmarked by excessive lipid accumulation and dysregulation, continues to escalate the prevalence of cardiometabolic diseases, and is a foremost…”
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Exhaled Breath Isoprene Rises During Hypoglycemia in Type 1 Diabetes by Neupane, Sankalpa, Peverall, Robert, Richmond, Graham, Blaikie, Tom P J, Taylor, David, Hancock, Gus, Evans, Mark L

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Computed Cardiopulmonography for the Detection of Early Smoking-Related Changes in the Lungs of Young Individuals Who Smoke by Redmond, Jennifer L., Kendall, Fiona, Smith, Nicholas M.J., Magor-Elliott, Snapper R.M., Hallifax, Rob J., Fullerton, Christopher J., Richmond, Graham, Couper, John H., Ritchie, Grant A.D., Robbins, Peter A., Petousi, Nayia, Talbot, Nick P.

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Computed cardiopulmonography and the idealized lung clearance index, iLCI 2.5 , in early-stage cystic fibrosis by Sandhu, Dominic, Redmond, Jennifer L, Smith, Nicholas M J, Short, Christopher, Saunders, Clare J, Couper, John H, Fullerton, Christopher J, Richmond, Graham, Talbot, Nick P, Davies, Jane C, Ritchie, Grant A D, Robbins, Peter A

“…This study explored the use of computed cardiopulmonography (CCP) to assess lung function in early-stage cystic fibrosis (CF). CCP has two components. The…”
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Computed cardiopulmonography and the idealized lung clearance index, iLCI2.5, in early-stage cystic fibrosis by Sandhu, Dominic, Redmond, Jennifer L, Smith, Nicholas M J, Short, Christopher, Saunders, Clare J, Couper, John H, Fullerton, Christopher J, Richmond, Graham, Talbot, Nick P, Davies, Jane C, Ritchie, Grant A D, Robbins, Peter A

“…This study explored the use of computed cardiopulmonography (CCP) to assess lung function in early-stage cystic fibrosis (CF). CCP has two components. The…”
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The correlation between breath acetone and blood betahydroxybutyrate in individuals with type 1 diabetes by Hancock, Gus, Sharma, Shrinivas, Galpin, Martin, Lunn, Daniel, Megson, Clare, Peverall, Rob, Richmond, Graham, Ritchie, Grant A D, Owen, Katharine R

“…Ketone testing is an important element of the self-management of illness in type 1 diabetes. The aim of the present study was to see if a breath test for…”
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A dynamic model of the body gas stores for carbon dioxide, oxygen, and inert gases that incorporates circulatory transport delays to and from the lung by Magor-Elliott, Snapper R M, Fullerton, Christopher J, Richmond, Graham, Ritchie, Grant A D, Robbins, Peter A

“…Many models of the body's gas stores have been generated for specific purposes. Here, we seek to produce a more general purpose model that: ) is relevant for…”
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