Search Results - "Richman, Douglas D."

Highly precise measurement of HIV DNA by droplet digital PCR by Strain, Matthew C, Lada, Steven M, Luong, Tiffany, Rought, Steffney E, Gianella, Sara, Terry, Valeri H, Spina, Celsa A, Woelk, Christopher H, Richman, Douglas D

“…Deoxyribonucleic acid (DNA) of the human immunodeficiency virus (HIV) provides the most sensitive measurement of residual infection in patients on effective…”
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Antiviral Drug Discovery To Address the COVID-19 Pandemic by Richman, Douglas D

“…The magnitude of the morbidity and mortality inflicted upon the global population in less than 1 year has driven the inescapable conclusion that the discovery…”
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HIV persistence in tissue macrophages of humanized myeloid-only mice during antiretroviral therapy by Honeycutt, Jenna B, Thayer, William O, Baker, Caroline E, Ribeiro, Ruy M, Lada, Steven M, Cao, Youfang, Cleary, Rachel A, Hudgens, Michael G, Richman, Douglas D, Garcia, J Victor

“…Persistence of HIV is attributed primarily to latent infection of CD4 + T cells. Honeycutt et al . report that in humanized mice lacking T cells HIV can…”
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Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs by Katlama, Christine, Prof, Deeks, Steven G, MD, Autran, Brigitte, Prof, Martinez-Picado, Javier, Prof, van Lunzen, Jan, Prof, Rouzioux, Christine, Prof, Miller, Michael, PhD, Vella, Stefano, MD, Schmitz, Joern E, Prof, Ahlers, Jeffrey, PhD, Richman, Douglas D, MD, Sekaly, Rafick P, Dr

“…Summary Antiretroviral therapy for HIV infection needs lifelong access and strict adherence to regimens that are both expensive and associated with toxic…”
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Challenge of Finding a Cure for HIV Infection by Richman, Douglas D, Margolis, David M, Delaney, Martin, Greene, Warner C, Hazuda, Daria, Pomerantz, Roger J

“…Although combination therapy for HIV infection represents a triumph for modern medicine, chronic suppressive therapy is required to contain persistent…”
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Rates of emergence of HIV drug resistance in resource-limited settings: a systematic review by Stadeli, Kathryn M, Richman, Douglas D

“…The increasing availability of antiretroviral therapy (ART) has improved survival and quality of life for many infected with HIV, but can also engender drug…”
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Minority Variants of Drug-Resistant HIV by Gianella, Sara, Richman, Douglas D.

“…Minor drug-resistant variants exist in every patient infected with human immunodeficiency virus (HIV). Because these minority variants are usually present at…”
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HIV Type 1 (HIV-1) Proviral Reservoirs Decay Continuously Under Sustained Virologic Control in HIV-1-Infected Children Who Received Early Treatment by LUZURIAGA, Katherine, TABAK, Barbara, CUNNINGHAM, Coleen K, PERSAUD, Deborah, GARBER, Manuel, YA HUI CHEN, ZIEMNIAK, Carrie, MCMANUS, Margaret M, MURRAY, Danielle, STRAIN, Matthew C, RICHMAN, Douglas D, CHUN, Tae-Wook

“…Early initiation of combination antiretroviral therapy (cART) to human immunodeficiency virus type 1 (HIV-1)-infected infants controls HIV-1 replication and…”
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Antiretroviral Drug Resistance Testing in Adult HIV-1 Infection: 2008 Recommendations of an International AIDS Society-USA Panel by Hirsch, Martin S., Günthard, Huldrych F., Schapiro, Jonathan M., Vézinet, Françoise Brun, Clotet, Bonaventura, Hammer, Scott M., Johnson, Victoria A., Kuritzkes, Daniel R., Mellors, John W., Pillay, Deenan, Yeni, Patrick G., Jacobsen, Donna M., Richman, Douglas D.

“…Resistance to antiretroviral drugs remains an important limitation to successful human immunodeficiency virus type 1 (HIV-1) therapy. Resistance testing can…”
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Virological suppression and clinical management in response to viremia in South African HIV treatment program: A multicenter cohort study by Hermans, Lucas E, Carmona, Sergio, Nijhuis, Monique, Tempelman, Hugo A, Richman, Douglas D, Moorhouse, Michelle, Grobbee, Diederick E, Venter, Willem D F, Wensing, Annemarie M J

“…Uptake of antiretroviral treatment (ART) is expanding rapidly in low- and middle-income countries (LMIC). Monitoring of virological suppression is recommended…”
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Human APOBEC3 induced mutation of human immunodeficiency virus type-1 contributes to adaptation and evolution in natural infection by Kim, Eun-Young, Lorenzo-Redondo, Ramon, Little, Susan J, Chung, Yoon-Seok, Phalora, Prabhjeet K, Maljkovic Berry, Irina, Archer, John, Penugonda, Sudhir, Fischer, Will, Richman, Douglas D, Bhattacharya, Tanmoy, Malim, Michael H, Wolinsky, Steven M

“…Human APOBEC3 proteins are cytidine deaminases that contribute broadly to innate immunity through the control of exogenous retrovirus replication and…”
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Temporal variation in HIV-specific IgG subclass antibodies during acute infection differentiates spontaneous controllers from chronic progressors by Sadanand, Saheli, Das, Jishnu, Chung, Amy W, Schoen, Matthew K, Lane, Sophie, Suscovich, Todd J, Streeck, Hendrik, Smith, Davey M, Little, Susan J, Lauffenburger, Douglas A, Richman, Douglas D, Alter, Galit

“…OBJECTIVE:Given the emerging appreciation for the role of antibody-dependent effector functions and IgG subclass distribution among spontaneous controllers of…”
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COVID-19 vaccines: implementation, limitations and opportunities by Richman, Douglas D.

“…The speed of development and the magnitude of efficacy of recently developed vaccines directed against SARS-CoV-2 has been truly remarkable. This editorial…”
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A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals by Procopio, Francesco Andrea, Fromentin, Rémi, Kulpa, Deanna A., Brehm, Jessica H., Bebin, Anne-Gaelle, Strain, Matthew C., Richman, Douglas D., O'Doherty, Una, Palmer, Sarah, Hecht, Frederick M., Hoh, Rebecca, Barnard, Richard J.O., Miller, Michael D., Hazuda, Daria J., Deeks, Steven G., Sékaly, Rafick-Pierre, Chomont, Nicolas

“…Quantifying latently infected cells is critical to evaluate the efficacy of therapeutic strategies aimed at reducing the size of the long-lived viral…”
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Rapid Evolution of the Neutralizing Antibody Response to HIV Type 1 Infection by Richman, Douglas D., Wrin, Terri, Little, Susan J., Petropoulos, Christos J.

“…A recombinant virus assay was used to characterize in detail neutralizing antibody responses directed at circulating autologous HIV in plasma. Examining serial…”
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CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells by Cockerham, Leslie R, Siliciano, Janet D, Sinclair, Elizabeth, O'Doherty, Una, Palmer, Sarah, Yukl, Steven A, Strain, Matt C, Chomont, Nicolas, Hecht, Frederick M, Siliciano, Robert F, Richman, Douglas D, Deeks, Steven G

“…The association between the host immune environment and the size of the HIV reservoir during effective antiretroviral therapy is not clear. Progress has also…”
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Virologic Monitoring of Hepatitis B Virus Therapy in Clinical Trials and Practice: Recommendations for a Standardized Approach by Pawlotsky, Jean–Michel, Dusheiko, Geoffrey, Hatzakis, Angelos, Lau, Daryl, Lau, George, Liang, T. Jake, Locarnini, Stephen, Martin, Paul, Richman, Douglas D, Zoulim, Fabien

“…Treatment of chronic hepatitis B virus (HBV) infection is aimed at suppressing viral replication to the lowest possible level, and thereby to halt the…”
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Persistence of Transmitted Drug Resistance among Subjects with Primary Human Immunodeficiency Virus Infection by LITTLE, Susan J, FROST, Simon D. W, WONG, Joseph K, SMITH, Davey M, KOSAKOVSKY POND, Sergei L, IGNACIO, Caroline C, PARKIN, Neil T, PETROPOULOS, Christos J, RICHMAN, Douglas D

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Detection of Minority Resistance during Early HIV-1 Infection: Natural Variation and Spurious Detection rather than Transmission and Evolution of Multiple Viral Variants by Gianella, Sara, Delport, Wayne, Pacold, Mary E, Young, Jason A, Choi, Jun Yong, Little, Susan J, Richman, Douglas D, Kosakovsky Pond, Sergei L, Smith, Davey M

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Depletion of latent HIV-1 infection in vivo: a proof-of-concept study by Lehrman, Ginger, Hogue, Ian B, Palmer, Sarah, Jennings, Cheryl, Spina, Celsa A, Wiegand, Ann, Landay, Alan L, Coombs, Robert W, Richman, Douglas D, Mellors, John W, Coffin, John M, Bosch, Ronald J, Margolis, David M

“…Persistent infection in resting CD4+ T cells prevents eradication of HIV-1. Since the chromatin remodeling enzyme histone deacetylase 1 (HDAC1) maintains…”
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