Search Results - "Richman, D D"

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy by Archin, N. M., Liberty, A. L., Kashuba, A. D., Choudhary, S. K., Kuruc, J. D., Crooks, A. M., Parker, D. C., Anderson, E. M., Kearney, M. F., Strain, M. C., Richman, D. D., Hudgens, M. G., Bosch, R. J., Coffin, J. M., Eron, J. J., Hazuda, D. J., Margolis, D. M.

“…The latent HIV-1 reservoir represents a major barrier to curing patients with HIV-1 infection, and now in vivo evidence is presented that vorinostat can…”
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Highly precise measurement of HIV DNA by droplet digital PCR by Strain, Matthew C, Lada, Steven M, Luong, Tiffany, Rought, Steffney E, Gianella, Sara, Terry, Valeri H, Spina, Celsa A, Woelk, Christopher H, Richman, Douglas D

“…Deoxyribonucleic acid (DNA) of the human immunodeficiency virus (HIV) provides the most sensitive measurement of residual infection in patients on effective…”
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HIV chemotherapy by Richman, Douglas D

“…The use of chemotherapy to suppress replication of the human immunodeficiency virus (HIV) has transformed the face of AIDS in the developed world. Pronounced…”
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Clinical-Grade Detection of Microsatellite Instability in Colorectal Tumors by Deep Learning by Echle, Amelie, Grabsch, Heike Irmgard, Quirke, Philip, van den Brandt, Piet A., West, Nicholas P., Hutchins, Gordon G.A., Heij, Lara R., Tan, Xiuxiang, Richman, Susan D., Krause, Jeremias, Alwers, Elizabeth, Jenniskens, Josien, Offermans, Kelly, Gray, Richard, Brenner, Hermann, Chang-Claude, Jenny, Trautwein, Christian, Pearson, Alexander T., Boor, Peter, Luedde, Tom, Gaisa, Nadine Therese, Hoffmeister, Michael, Kather, Jakob Nikolas

“…Microsatellite instability (MSI) and mismatch-repair deficiency (dMMR) in colorectal tumors are used to select treatment for patients. Deep learning can detect…”
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Antiviral Drug Discovery To Address the COVID-19 Pandemic by Richman, Douglas D

“…The magnitude of the morbidity and mortality inflicted upon the global population in less than 1 year has driven the inescapable conclusion that the discovery…”
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HIV persistence in tissue macrophages of humanized myeloid-only mice during antiretroviral therapy by Honeycutt, Jenna B, Thayer, William O, Baker, Caroline E, Ribeiro, Ruy M, Lada, Steven M, Cao, Youfang, Cleary, Rachel A, Hudgens, Michael G, Richman, Douglas D, Garcia, J Victor

“…Persistence of HIV is attributed primarily to latent infection of CD4 + T cells. Honeycutt et al . report that in humanized mice lacking T cells HIV can…”
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Mismatch repair status and BRAF mutation status in metastatic colorectal cancer patients: a pooled analysis of the CAIRO, CAIRO2, COIN, and FOCUS studies by Venderbosch, Sabine, Nagtegaal, Iris D, Maughan, Tim S, Smith, Christopher G, Cheadle, Jeremy P, Fisher, David, Kaplan, Richard, Quirke, Philip, Seymour, Matthew T, Richman, Susan D, Meijer, Gerrit A, Ylstra, Bauke, Heideman, Danielle A M, de Haan, Anton F J, Punt, Cornelis J A, Koopman, Miriam

“…To determine the prevalence and prognostic value of mismatch repair (MMR) status and its relation to BRAF mutation (BRAF(MT)) status in metastatic colorectal…”
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Rapid Evolution of the Neutralizing Antibody Response to HIV Type 1 Infection by Richman, Douglas D., Wrin, Terri, Little, Susan J., Petropoulos, Christos J.

“…A recombinant virus assay was used to characterize in detail neutralizing antibody responses directed at circulating autologous HIV in plasma. Examining serial…”
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Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs by Katlama, Christine, Prof, Deeks, Steven G, MD, Autran, Brigitte, Prof, Martinez-Picado, Javier, Prof, van Lunzen, Jan, Prof, Rouzioux, Christine, Prof, Miller, Michael, PhD, Vella, Stefano, MD, Schmitz, Joern E, Prof, Ahlers, Jeffrey, PhD, Richman, Douglas D, MD, Sekaly, Rafick P, Dr

“…Summary Antiretroviral therapy for HIV infection needs lifelong access and strict adherence to regimens that are both expensive and associated with toxic…”
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Antiretroviral Drug Resistance Testing in Adult HIV-1 Infection: 2008 Recommendations of an International AIDS Society-USA Panel by Hirsch, Martin S., Günthard, Huldrych F., Schapiro, Jonathan M., Vézinet, Françoise Brun, Clotet, Bonaventura, Hammer, Scott M., Johnson, Victoria A., Kuritzkes, Daniel R., Mellors, John W., Pillay, Deenan, Yeni, Patrick G., Jacobsen, Donna M., Richman, Douglas D.

“…Resistance to antiretroviral drugs remains an important limitation to successful human immunodeficiency virus type 1 (HIV-1) therapy. Resistance testing can…”
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Challenge of Finding a Cure for HIV Infection by Richman, Douglas D, Margolis, David M, Delaney, Martin, Greene, Warner C, Hazuda, Daria, Pomerantz, Roger J

“…Although combination therapy for HIV infection represents a triumph for modern medicine, chronic suppressive therapy is required to contain persistent…”
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Rates of emergence of HIV drug resistance in resource-limited settings: a systematic review by Stadeli, Kathryn M, Richman, Douglas D

“…The increasing availability of antiretroviral therapy (ART) has improved survival and quality of life for many infected with HIV, but can also engender drug…”
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KRAS and BRAF Mutations in Advanced Colorectal Cancer Are Associated With Poor Prognosis but Do Not Preclude Benefit From Oxaliplatin or Irinotecan: Results From the MRC FOCUS Trial by Richman, Susan D, Seymour, Matthew T, Chambers, Philip, Elliott, Faye, Daly, Catherine L, Meade, Angela M, Taylor, Graham, Barrett, Jennifer H, Quirke, Philip

“…Activating mutation of the KRAS oncogene is an established predictive biomarker for resistance to anti-epidermal growth factor receptor (anti-EGFR) therapies…”
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Lipoprotein-like receptor 4 antibodies in myasthenia gravis: pathogenic or protective by Richman, D. P.

“…Click here to view the accompanying paper in this issue…”
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HIV-1 Expression Within Resting CD4⁺ T Cells After Multiple Doses of Vorinostat by Archin, Nancy M., Bateson, Rosalie, Tripathy, Manoj K., Crooks, Amanda M., Yang, Kuo-Hsiung, Dahl, Noelle P., Kearney, Mary F., Anderson, Elizabeth M., Coffin, John M., Strain, Matthew, Richman, Douglas D., Robertson, Kevin R., Kashuba, Angela D., Bosch, Ronald J., Hazuda, Daria J., Kuruc, Joann D., Eron, Joseph J., Margolis, David M.

“…Background. A single dose of the histone deacetylase inhibitor vorinostat (VOR) up-regulates HIV RNA expression within resting CD4⁺ T cells of treated,…”
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Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies by Eriksson, Susanne, Graf, Erin H, Dahl, Viktor, Strain, Matthew C, Yukl, Steven A, Lysenko, Elena S, Bosch, Ronald J, Lai, Jun, Chioma, Stanley, Emad, Fatemeh, Abdel-Mohsen, Mohamed, Hoh, Rebecca, Hecht, Frederick, Hunt, Peter, Somsouk, Ma, Wong, Joseph, Johnston, Rowena, Siliciano, Robert F, Richman, Douglas D, O'Doherty, Una, Palmer, Sarah, Deeks, Steven G, Siliciano, Janet D

“…HIV-1 reservoirs preclude virus eradication in patients receiving highly active antiretroviral therapy (HAART). The best characterized reservoir is a small,…”
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An international, phase III, randomized trial of mycophenolate mofetil in myasthenia gravis by SANDERS, D. B, HART, I. K, MANTEGAZZA, R, SHUKLA, S. S, SIDDIQI, Z. A, DE BAETS, M. H. V, MELMS, A, NICOLLE, M. W, SOLOMONS, N, RICHMAN, D. P

“…This prospective, randomized, double-blind, placebo-controlled, phase III trial assessed the efficacy, safety, and tolerability of mycophenolate mofetil (MMF)…”
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The prevalence of antiretroviral drug resistance in the United States by RICHMAN, Douglas D, MORTON, Sally C, WRIN, Terri, HELLMANN, Nicholas, BERRY, Sandra, SHAPIRO, Martin F, BOZZETTE, Samuel A

“…Antiretroviral therapy has dramatically reduced the morbidity and mortality of infection due to HIV. The emergence of drug-resistant virus has limited the…”
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HIV Type 1 (HIV-1) Proviral Reservoirs Decay Continuously Under Sustained Virologic Control in HIV-1-Infected Children Who Received Early Treatment by LUZURIAGA, Katherine, TABAK, Barbara, CUNNINGHAM, Coleen K, PERSAUD, Deborah, GARBER, Manuel, YA HUI CHEN, ZIEMNIAK, Carrie, MCMANUS, Margaret M, MURRAY, Danielle, STRAIN, Matthew C, RICHMAN, Douglas D, CHUN, Tae-Wook

“…Early initiation of combination antiretroviral therapy (cART) to human immunodeficiency virus type 1 (HIV-1)-infected infants controls HIV-1 replication and…”
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A robust multiplex immunofluorescence and digital pathology workflow for the characterisation of the tumour immune microenvironment by Viratham Pulsawatdi, Amélie, Craig, Stephanie G., Bingham, Victoria, McCombe, Kris, Humphries, Matthew P., Senevirathne, Seedevi, Richman, Susan D., Quirke, Phil, Campo, Leticia, Domingo, Enric, Maughan, Timothy S., James, Jacqueline A., Salto‐Tellez, Manuel

“…Optimisation and validation of a multiplex immunofluorescence (mIF) workflow, from staining to digital image analysis (DIA), ensure assay robustness…”
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