Search Results - "Riching, Andrew S."

3D Collagen Alignment Limits Protrusions to Enhance Breast Cancer Cell Persistence by Riching, Kristin M., Cox, Benjamin L., Salick, Max R., Pehlke, Carolyn, Riching, Andrew S., Ponik, Susan M., Bass, Benjamin R., Crone, Wendy C., Jiang, Yi, Weaver, Alissa M., Eliceiri, Kevin W., Keely, Patricia J.

“…Patients with mammographically dense breast tissue have a greatly increased risk of developing breast cancer. Dense breast tissue contains more stromal…”
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Lysosomal Abnormalities in Cardiovascular Disease by Chi, Congwu, Riching, Andrew S, Song, Kunhua

“…The lysosome, a key organelle for cellular clearance, is associated with a wide variety of pathological conditions in humans. Lysosome function and its related…”
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Cardiac Regeneration: New Insights Into the Frontier of Ischemic Heart Failure Therapy by Riching, Andrew S, Song, Kunhua

“…Ischemic heart disease is the leading cause of morbidity and mortality in the world. While pharmacological and surgical interventions developed in the late…”
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Interferon hyperactivity impairs cardiogenesis in Down syndrome via downregulation of canonical Wnt signaling by Chi, Congwu, Knight, Walter E., Riching, Andrew S., Zhang, Zhen, Tatavosian, Roubina, Zhuang, Yonghua, Moldovan, Radu, Rachubinski, Angela L., Gao, Dexiang, Xu, Hongyan, Espinosa, Joaquin M., Song, Kunhua

“…Congenital heart defects (CHDs) are frequent in children with Down syndrome (DS), caused by trisomy of chromosome 21. However, the underlying mechanisms are…”
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Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation by Stratton, Matthew S, Bagchi, Rushita A, Felisbino, Marina B, Hirsch, Rachel A, Smith, Harrison E, Riching, Andrew S, Enyart, Blake Y, Koch, Keith A, Cavasin, Maria A, Alexanian, Michael, Song, Kunhua, Qi, Jun, Lemieux, Madeleine E, Srivastava, Deepak, Lam, Maggie P.Y, Haldar, Saptarsi M, Lin, Charles Y, McKinsey, Timothy A

“…RATIONALE:Small molecule inhibitors of the acetyl-histone binding protein BRD4 have been shown to block cardiac fibrosis in preclinical models of heart failure…”
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Cardiomyocyte-Specific Long Noncoding RNA Regulates Alternative Splicing of the Triadin Gene in the Heart by Zhao, Yuanbiao, Riching, Andrew S., Knight, Walter E., Chi, Congwu, Broadwell, Lindsey J., Du, Yanmei, Abdel-Hafiz, Mostafa, Ambardekar, Amrut V., Irwin, David C., Proenza, Catherine, Xu, Hongyan, Leinwand, Leslie A., Walker, Lori A., Woulfe, Kathleen C., Bristow, Michael R., Buttrick, Peter M., Song, Kunhua

“…Abnormalities in Ca homeostasis are associated with cardiac arrhythmias and heart failure. Triadin plays an important role in Ca homeostasis in cardiomyocytes…”
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Suppression of canonical TGF-β signaling enables GATA4 to interact with H3K27me3 demethylase JMJD3 to promote cardiomyogenesis by Riching, Andrew S., Danis, Etienne, Zhao, Yuanbiao, Cao, Yingqiong, Chi, Congwu, Bagchi, Rushita A., Klein, Brianna J., Xu, Hongyan, Kutateladze, Tatiana G., McKinsey, Timothy A., Buttrick, Peter M., Song, Kunhua

“…Direct reprogramming of fibroblasts into cardiomyocytes (CMs) represents a promising strategy to regenerate CMs lost after ischemic heart injury…”
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The Brain–Heart Axis: Alzheimer’s, Diabetes, and Hypertension by Riching, Andrew S, Major, Jennifer L, Londono, Pilar, Bagchi, Rushita A

“…Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder affecting millions worldwide. Currently, there are only four approved treatments for AD,…”
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Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes by Riching, Andrew S, Zhao, Yuanbiao, Cao, Yingqiong, Londono, Pilar, Xu, Hongyan, Song, Kunhua

“…Trans-differentiation of one somatic cell type into another has enormous potential to model and treat human diseases. Previous studies have shown that mouse…”
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A Facile, Transfection-Free Approach to siRNA Delivery in In Vitro 3D Spheroid Models by Riching, Andrew S, Malloy, Allyson, Anderson, Emily M, Sheard, Jonathan, Mikkonen, Piia, van Brabant Smith, Anja, Strezoska, Zaklina, Levenga, Josien

“…Cell culture has long been essential for preclinical modeling of human development and disease. However, conventional two-dimensional (2D) cell culture fails…”
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Cardiomyocyte-Specific Long Noncoding RNA Regulates Alternative Splicing of the Triadin Gene in the Heart by Zhao, Yuanbiao, Riching, Andrew S., Knight, Walter E., Chi, Congwu, Broadwell, Lindsey J., Du, Yanmei, Abdel-Hafiz, Mostafa, Ambardekar, Amrut V., Irwin, David C., Proenza, Catherine, Xu, Hongyan, Leinwand, Leslie A., Walker, Lori A., Woulfe, Kathleen C., Bristow, Michael R., Buttrick, Peter M., Song, Kunhua

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Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes by Riching, Andrew S., Zhao, Yuanbiao, Cao, Yingqiong, Londono, Pilar, Xu, Hongyan, Song, Kunhua

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