An Evaluation of Bone Health Parameters in Regularly Transfused Beta-Thalassemia Major Patients

As beta-thalassemia major patients need regular blood transfusions due to the severe hemoglobin deficiency, the occurrence of related bone defects with simultaneous fluctuations in the biochemical and hematologic parameters is seen. The hospital-based cross-sectional observational study was done to...

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Bibliographic Details
Published in:	Journal of pediatric hematology/oncology Vol. 42; no. 6; pp. 381 - 385
Main Authors:	Kothimira, Vamsi K., Kumar, Arun, Richhele, Lala R., Sood, Neelam, Gulati, Anil
Format:	Journal Article
Language:	English
Published:	United States Lippincott Williams & Wilkins 01-08-2020
Subjects:	beta-Thalassemia - therapy Blood Transfusion - methods Bone Density Child Cross-Sectional Studies Female Follow-Up Studies Humans India - epidemiology Male Osteoporosis - epidemiology Prevalence Prognosis India
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Summary:	As beta-thalassemia major patients need regular blood transfusions due to the severe hemoglobin deficiency, the occurrence of related bone defects with simultaneous fluctuations in the biochemical and hematologic parameters is seen. The hospital-based cross-sectional observational study was done to determine and correlate the bone mineral density (BMD) with biochemical parameters and hematologic parameters in 50 regularly transfused beta-thalassemia major patients of older than 6 years of age. Descriptive statistics were analyzed with SPSS version 20.0 software. A P<0.05 was considered as statistically significant. The prevalence of suboptimal BMD at lumbar spine was 86% and at femur neck was 74%. A statistically significant correlation of BMD was found with mean pretransfusion hemoglobin values, serum calcium levels, and serum vitamin D levels (P<0.05). It was concluded that continuous monitoring of the BMD, biochemical, and hematologic parameters in regularly transfused beta-thalassemia major patients may help assess the ongoing deficiencies; helping to maintain timely and regular blood transfusions with supplementation of calcium, vitamin D to ensure good bone health.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23
ISSN:	1077-4114 1536-3678
DOI:	10.1097/MPH.0000000000001733