Search Results - "Richfield, Eric K."

Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis by Stumpo, Deborah J., Broxmeyer, Hal E., Ward, Toni, Cooper, Scott, Hangoc, Giao, Chung, Yang Jo, Shelley, William C., Richfield, Eric K., Ray, Manas K., Yoder, Mervin C., Aplan, Peter D., Blackshear, Perry J.

“…Members of the tristetraprolin family of tandem CCCH finger proteins can bind to AU-rich elements in the 3′-untranslated region of mRNAs, leading to their…”
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Overexpression of Superoxide Dismutase or Glutathione Peroxidase Protects against the Paraquat + Maneb-induced Parkinson Disease Phenotype by Thiruchelvam, Mona, Prokopenko, Olga, Cory-Slechta, Deborah A., Richfield, Eric K., Buckley, Brian, Mirochnitchenko, Oleg

“…Oxidative stress has been implicated in the pathogenesis of Parkinson disease based on its role in the cascade of biochemical changes that lead to dopaminergic…”
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Prolonged Toxicokinetics and Toxicodynamics of Paraquat in Mouse Brain by Kavita Prasad, Bozena Winnik, Mona J. Thiruchelvam, Buckley, Brian, Mirochnitchenko, Oleg, Richfield, Eric K.

“…Background: Paraquat (PQ) has been implicated as a risk factor for the Parkinson disease phenotype (PDP) in humans and mice using epidemiologic or experimental…”
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Proteasome dysfunction in aged human α-synuclein transgenic mice by Chen, Li, Thiruchelvam, Mona J., Madura, Kiran, Richfield, Eric K.

“…A deficit in proteasome function in Parkinson's disease has been speculated. We characterized the ubiquitin–proteasome system in three regions of brain from…”
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The Nigrostriatal Dopaminergic System as a Preferential Target of Repeated Exposures to Combined Paraquat and Maneb: Implications for Parkinson's Disease by Thiruchelvam, Mona, Richfield, Eric K, Baggs, Raymond B, Tank, Arnold W, Cory-Slechta, Deborah A

“…Experimental evidence supporting 1,1'-dimethyl-4,4'-bipyridinium [paraquat (PQ)] as a risk factor for Parkinson's disease (PD) is equivocal. Other agricultural…”
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Age-related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotype by Thiruchelvam, Mona, McCormack, Alison, Richfield, Eric K., Baggs, Raymond B., Tank, A. William, Di Monte, Donato A., Cory-Slechta, Deborah A.

“…While advancing age is the only unequivocally accepted risk factor for idiopathic Parkinson's disease, it has been postulated that exposure to environmental…”
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Sporadic midbrain dopamine neuron abnormalities in laboratory mice by Prasad, Kavita, Richfield, Eric K

“…Abstract We report an anatomical abnormality of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and ventral tegmental area (VTA) in different…”
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Neuronal migration defect of the developing cerebellar vermis in substrains of C57BL/6 mice: cytoarchitecture and prevalence of molecular layer heterotopia by Mangaru, Zareema, Salem, Elsaid, Sherman, Matthew, Van Dine, Sarah E, Bhambri, Ankur, Brumberg, Joshua C, Richfield, Eric K, Gabel, Lisa A, Ramos, Raddy L

“…Abnormal development of the cerebellum is often associated with disorders of movement, postural control, and motor learning. Rodent models are widely used to…”
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Zfp36l3, a Rodent X Chromosome Gene Encoding a Placenta-Specific Member of the Tristetraprolin Family of CCCH Tandem Zinc Finger Proteins by Blackshear, Perry J, Phillips, Ruth S, Ghosh, Sanjukta, Ramos, Silvia V. B, Richfield, Eric K, Lai, Wi S

“…Members of the tristetraprolin (TTP) family of CCCH tandem zinc finger (TZF) proteins can bind directly to AU-rich elements (ARE) in mRNA, causing…”
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Increased synaptosomal dopamine content and brain concentration of paraquat produced by selective dithiocarbamates by Barlow, Brian K., Thiruchelvam, Mona J., Bennice, Lisa, Cory‐Slechta, Deborah A., Ballatori, Nazzareno, Richfield, Eric K.

“…Exposure to pesticides may be a risk factor for Parkinson's disease based on epidemiologic data in humans, animal models and in vitro studies. Different…”
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Critical Role of Truncated α-Synuclein and Aggregates in Parkinson's Disease and Incidental Lewy Body Disease by Prasad, Kavita, Beach, Thomas G., Hedreen, John, Richfield, Eric K.

“…The role of Lewy bodies, Lewy neurites and α‐synuclein (αSYN) in the pathophysiology and diagnosis of Parkinson's disease (PD) is unclear. We used postmortem…”
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Number and nuclear morphology of TH+ and TH− neurons in the mouse ventral midbrain using epifluorescence stereology by Prasad, Kavita, Richfield, Eric K.

“…The accurate and reliable counting of tyrosine hydroxylase positive (TH+) and tyrosine hydroxylase negative (TH−) neurons in the ventral midbrain is an…”
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Toxicokinetics and toxicodynamics of paraquat accumulation in mouse brain by Prasad, Kavita, Tarasewicz, Elizabeth, Mathew, Jason, Strickland, Pamela A. Ohman, Buckley, Brian, Richardson, Jason R., Richfield, Eric K.

“…Paraquat (PQ) is a potential human neurotoxicant and is used in models of oxidative stress. We determined the toxicokinetics (TK) and toxicodynamics (TD) of PQ…”
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The gestational environment and Parkinson's disease: Evidence for neurodevelopmental origins of a neurodegenerative disorder by Barlow, Brian K., Cory-Slechta, Deborah A., Richfield, Eric K., Thiruchelvam, Mona

“…Parkinson's Disease (PD) is a degenerative neurological disorder that typically manifests symptoms in late adulthood, after loss of dopaminergic neurons in the…”
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Quantification of Paraquat, MPTP, and MPP⁺ in brain tissue using microwave-assisted solvent extraction (MASE) and high-performance liquid chromatography-mass spectrometry by Winnik, Bozena, Barr, Dana B, Thiruchelvam, Mona, Montesano, M. Angela, Richfield, Eric K, Buckley, Brian

“…Animal models, consistent with the hypothesis of direct interaction of paraquat (PQ) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) with specific…”
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Developmental Pesticide Models of the Parkinson Disease Phenotype by Cory-Slechta, Deborah A., Thiruchelvam, Mona, Barlow, Brian K., Richfield, Eric K.

“…It has been hypothesized that developmental insults could contribute to Parkinson disease (PD), a neurodegenerative disorder resulting from the loss of the…”
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Behavioral and Neurochemical Effects of Wild-Type and Mutated Human α-Synuclein in Transgenic Mice by Richfield, Eric K., Thiruchelvam, Mona J., Cory-Slechta, Deborah A., Wuertzer, Charles, Gainetdinov, Raul R., Caron, Marc G., Di Monte, Donato A., Federoff, Howard J.

“…Human α-synuclein (hα-SYN) is implicated in the Parkinson's disease phenotype (PDP) based on a variety of studies in man, animal models, and in vitro studies…”
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Genetic-based, differential susceptibility to paraquat neurotoxicity in mice by Yin, Lina, Lu, Lu, Prasad, Kavita, Richfield, Eric K, Unger, Erica L, Xu, Jialin, Jones, Byron C

“…Abstract Paraquat (PQ) is an herbicide used extensively in agriculture. This agent is also suspected to be a risk factor for Parkinson's disease (PD) by…”
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Molecular layer heterotopia of the cerebellar vermis in mutant and transgenic mouse models on a C57BL/6 background by Ramos, Raddy L, Van Dine, Sarah E, George, Elizabeth, Patel, Dhruv, Hoplight, Blair J, Leheste, Joerg R, Richfield, Eric K, Torres, German

“…Highlights • Mutant mice on a C57BL/6 background exhibit cerebellar heterotopia. • Cre-transgenic mice on a C57BL/6 background exhibit cerebellar heterotopia…”
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Neocortical molecular layer heterotopia in substrains of C57BL/6 and C57BL/10 mice by Lipoff, Danielle M, Bhambri, Ankur, Fokas, Georgia J, Sharma, Sanjeev, Gabel, Lisa A, Brumberg, Joshua C, Richfield, Eric K, Ramos, Raddy L

“…Abstract Abnormal development of the neocortex is often associated with cognitive deficits and epilepsy. Rodent models are widely used to study normal and…”
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