Search Results - "Richey, Tina"

Preclinical evaluation of Tc-99m p5+14 peptide for SPECT detection of cardiac amyloidosis by Kennel, Stephen J, Jackson, Joseph W, Stuckey, Alan, Richey, Tina, Foster, James S, Wall, Jonathan S

“…Amyloid deposition is a cause of restrictive cardiomyopathy. Patients who present with cardiac disease can be evaluated for transthyretin (TTR)-associated…”
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AL amyloid imaging and therapy with a monoclonal antibody to a cryptic epitope on amyloid fibrils by Wall, Jonathan S, Kennel, Stephen J, Williams, Angela, Richey, Tina, Stuckey, Alan, Huang, Ying, Macy, Sallie, Donnell, Robert, Barbour, Robin, Seubert, Peter, Schenk, Dale

“…The monoclonal antibody 2A4 binds an epitope derived from a cleavage site of serum amyloid protein A (sAA) containing a -Glu-Asp- amino acid pairing. In…”
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Development and characterization of a prototypic pan-amyloid clearing agent – a novel murine peptide-immunoglobulin fusion by Foster, James S., Balachandran, Manasi, Hancock, Trevor J., Martin, Emily B., Macy, Sallie, Wooliver, Craig, Richey, Tina, Stuckey, Alan, Williams, Angela D., Jackson, Joseph W., Kennel, Stephen J., Wall, Jonathan S.

“…Introduction Systemic amyloidosis is a progressive disorder characterized by the extracellular deposition of amyloid fibrils and accessory proteins in visceral…”
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Macrophage-Mediated Phagocytosis and Dissolution of Amyloid-Like Fibrils in Mice, Monitored by Optical Imaging by Richey, Tina, Foster, James S., Williams, Angela D., Williams, Anna B., Stroh, Alexa, Macy, Sallie, Wooliver, Craig, Heidel, R. Eric, Varanasi, Siva K., Ergen, Elizabeth N., Trent, Dianne J., Kania, Stephen A., Kennel, Stephen J., Martin, Emily B., Wall, Jonathan S.

“…Light chain–associated amyloidosis is characterized by the extracellular deposition of amyloid fibrils in abdominothoracic organs, skin, soft tissue, and…”
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In vivo molecular imaging of peripheral amyloidosis using heparin-binding peptides by Wall, Jonathan S, Richey, Tina, Stuckey, Alan, Donnell, Robert, Macy, Sallie, Martin, Emily B, Williams, Angela, Higuchi, Keiichi, Kennel, Stephen J

“…Heparan sulfate proteoglycans (HSPGs) are ubiquitous components of pathologic amyloid deposits in the organs of patients with disorders such as Alzheimer's…”
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Amyloidogenic potential of foie gras by Solomon, Alan, Richey, Tina, Murphy, Charles L, Weiss, Deborah T, Wall, Jonathan S, Westermark, Gunilla T, Westermark, Per

“…The human cerebral and systemic amyloidoses and prion-associated spongiform encephalopathies are acquired or inherited protein folding disorders in which…”
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Evaluation of the effect of D-amino acid incorporation into amyloid-reactive peptides by Martin, Emily B, Williams, Angela, Richey, Tina, Wooliver, Craig, Stuckey, Alan, Foster, James S, Kennel, Stephen J, Wall, Jonathan S

“…Systemic amyloidoses comprise diseases characterized by the deposition of proteinaceous material known as amyloid. Currently, without performing multiple…”
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Preclinical Validation of the Heparin-Reactive Peptide p5+14 as a Molecular Imaging Agent for Visceral Amyloidosis by Wall, Jonathan S, Martin, Emily B, Richey, Tina, Stuckey, Alan C, Macy, Sallie, Wooliver, Craig, Williams, Angela, Foster, James S, McWilliams-Koeppen, Penney, Uberbacher, Ed, Cheng, Xiaolin, Kennel, Stephen J

“…Amyloid is a complex pathologic matrix comprised principally of paracrystalline protein fibrils and heparan sulfate proteoglycans. Systemic amyloid diseases…”
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Characterization of X-ray Dose in Murine Animals Using microCT, a New Low-Dose Detector and nanoDot Dosimeters by Osborne, Dustin R, Yan, Shikui, Stuckey, Alan, Pryer, Lindy, Richey, Tina, Wall, Jonathan S

“…Dose continues to be an area of concern in preclinical imaging studies, especially for those imaging disease progression in longitudinal studies. To our…”
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A binding-site barrier affects imaging efficiency of high affinity amyloid-reactive peptide radiotracers in vivo by Wall, Jonathan S, Williams, Angela, Richey, Tina, Stuckey, Alan, Huang, Ying, Wooliver, Craig, Macy, Sallie, Heidel, Eric, Gupta, Neil, Lee, Angela, Rader, Brianna, Martin, Emily B, Kennel, Stephen J

“…Amyloid is a complex pathology associated with a growing number of diseases including Alzheimer's disease, type 2 diabetes, rheumatoid arthritis, and myeloma…”
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A Peptide-Fc Opsonin with Pan-Amyloid Reactivity by Foster, James S, Williams, Angela D, Macy, Sallie, Richey, Tina, Stuckey, Alan, Wooliver, Daniel Craig, Koul-Tiwari, Richa, Martin, Emily B, Kennel, Stephen J, Wall, Jonathan S

“…There is a continuing need for therapeutic interventions for patients with the protein misfolding disorders that result in systemic amyloidosis. Recently,…”
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Phagocyte depletion inhibits AA amyloid accumulation in AEF-induced huIL-6 transgenic mice by Kennel, Stephen J., Macy, Sally, Wooliver, Craig, Huang, Ying, Richey, Tina, Heidel, Eric, Wall, Jonathan S.

“…Abstract Objective: Determine the role of phagocytosis in the deposition of acute phase SAA protein in peripheral organs as AA amyloid. Methods: AA amyloidosis…”
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Early Development and Pre-Clinical Evaluation of a Fluorine-18 Labeled Peptide p5+14 for PET/CT Imaging of Cardiac Amyloidosis by Webster, Eric, Kennel, Stephen J., Stuckey, Alan, Richey, Tina, Raj, Renju, Martin, Emily B, Wall, Jonathan S.

“…Background:Systemic amyloidosis is a rare protein misfolding disorder, where patients can present with varied symptoms due to the diverse organ involvement…”
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The Peptide Fusion Immunoglobulin, AT-02, Exhibits Highly Potent Pan-Amyloid Reactivity And Immunomodulation by Wall, Jonathan, Klein, Michael, Guthrie, Spencer, Foster, James S., Williams, Angela, Richey, Tina, Balachandran, Manasi, Jackson, Joseph, Hancock, Trevor, Stuckey, Alan, Martin, Emily, Kennel, Stephen

“…Cardiac amyloidosis is an ominous manifestation of -systemic amyloidosis, notably in AL and ATTR-associated types, resulting in a restrictive hypertrophic…”
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Discrete binding patterns of two heparin-reactive proteins, basic fibroblast growth factor and peptide p5R, in amyloid-laden and healthy mice by Martin, Emily B., Donnell, Robert, Richey, Tina, Stuckey, Alan, Kennel, Stephen J., Wall, Jonathan S.

“…Peptide p5R is a synthetic, polybasic, heparin-binding peptide that preferentially reacts with amyloid deposits in vivo and in tissue sections. Basic…”
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Cardiac Amyloid Detection by PET/CT Imaging of Iodine (124I) Evuzamitide (124I-p5+14) by Wall, Jonathan S., Martin, Emily B., Lands, Ronald, Ramchandren, Radhakrishnan, Stuckey, Alan, Heidel, R. Eric, Whittle, Bryan, Powell, Dustin, Richey, Tina, Williams, Angela D., Foster, James S., Guthrie, Spencer, Kennel, Stephen J.

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Cardiac Amyloid Detection by PET/CT Imaging of Iodine ( 124 I) Evuzamitide ( 124 I-p5+14): A Phase 1/2 Study by Wall, Jonathan S, Martin, Emily B, Lands, Ronald, Ramchandren, Radhakrishnan, Stuckey, Alan, Heidel, R Eric, Whittle, Bryan, Powell, Dustin, Richey, Tina, Williams, Angela D, Foster, James S, Guthrie, Spencer, Kennel, Stephen J

“…The noninvasive detection of cardiac amyloid, as well as deposits in other vital organs, is critical for early diagnosis and quantitative disease monitoring…”
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Preliminary pharmacokinetic study of a bispecific peptide for pretargeting immunotherapy of amyloidosis using PreClinical SPECT/CT by Stuckey, Alan, Williams, Angela, Richey, Tina, Macy, Sallie, Wooliver, Craig, Kennel, Steve, Wall, Jonathan

“…Objectives: Preliminary pharmacokinetic study of a bispecific peptide for pretargeting immunotherapy of amyloidosis using PreClinical SPECT/CT Amyloid…”
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Phase I IND-enabling studies for the amyloid-imaging peptide p5+14 (Api1832) - a novel agent for the detection of systemic amyloidosis by Stuckey, Alan, Williams, Angela, Richey, Tina, Moody, Carmella, Kennel, Steve, Wall, Jonathan

“…Objectives: here are approximately 4,500 new cases each year of systemic amyloidosis in the US. Despite decades of active research that have increased our…”
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Detection of Systemic AL Amyloidosis and Differentiation of AL from Attr Using 124I-p5+14 PET Imaging by Wall, Jonathan S., Heidel, R. Eric, Stuckey, Alan, Martin, Emily B., Richey, Tina, Williams, Angela, Foster, James S., Whittle, Bryan, Fu, Yitong, Powell, Dustin, Lands, Ronald H., Guthrie, Spencer, Kennel, Stephen J.

“…Background: Systemic immunoglobulin light chain-associated amyloidosis (AL) is a rare disorder associated with the production of monoclonal free light chain…”
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