Search Results - "Richett, Michael E."

Acyl Sulfonamide Anti-Proliferatives:  Benzene Substituent Structure−Activity Relationships for a Novel Class of Antitumor Agents by Lobb, Karen L, Hipskind, Philip A, Aikins, James A, Alvarez, Enrique, Cheung, Yiu-Yin, Considine, Eileen L, De Dios, Alfonso, Durst, Gregory L, Ferritto, Rafael, Grossman, Cora Sue, Giera, Deborah D, Hollister, Beth A, Huang, Zhongping, Iversen, Philip W, Law, Kevin L, Li, Tiechao, Lin, Ho-Shen, Lopez, Beatriz, Lopez, Jose E, Cabrejas, Luisa M. Martin, McCann, Denis J, Molero, Victoriano, Reilly, John E, Richett, Michael E, Shih, Chuan, Teicher, Beverly, Wikel, James H, White, Wesley T, Mader, Mary M

“…Two closely related diaryl acylsulfonamides were recently reported as potent antitumor agents against a broad spectrum of human tumor xenografts (colon, lung,…”
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Acyl sulfonamide anti-proliferatives. Part 2: Activity of heterocyclic sulfonamide derivatives by Mader, Mary M., Shih, Chuan, Considine, Eileen, Dios, Alfonso De, Grossman, Cora Sue, Hipskind, Philip A., Lin, Ho-Shen, Lobb, Karen L., Lopez, Beatriz, Lopez, José E., Cabrejas, Luisa M. Martin, Richett, Michael E., White, Wesley T., Cheung, Yiu-Yin, Huang, Zhongping, Reilly, John E., Dinn, Sean R.

“…The cytotoxic and oncolytic activity of heterocyclic and fused bicylic sulfonamide analogs is described. The anti-proliferative activity of acylated…”
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Diamino Benzo[b]thiophene Derivatives as a Novel Class of Active Site Directed Thrombin Inhibitors. 5. Potency, Efficacy, and Pharmacokinetic Properties of Modified C-3 Side Chain Derivatives by Sall, Daniel J, Bailey, Dianna L, Bastian, Jolie A, Buben, John A, Chirgadze, Nickolay Y, Clemens-Smith, Amy C, Denney, Michael L, Fisher, Matthew J, Giera, Deborah D, Gifford-Moore, Donetta S, Harper, Richard W, Johnson, Lea M, Klimkowski, Valentine J, Kohn, Todd J, Lin, Ho-Shen, McCowan, Jefferson R, Palkowitz, Alan D, Richett, Michael E, Smith, Gerald F, Snyder, David W, Takeuchi, Kumiko, Toth, John E, Zhang, Minsheng

“…A systematic investigation of the structure−activity relationships of the C-3 side chain of the screening hit 1a led to the identification of the potent…”
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Synthesis and in vitro biological activity of 4α-(2-propenyl)-5α-cholest-24-en-3α-ol: A 24,25-dehydro analog of the hypocholesterolemic agent 4α-(2-propenyl)-5α-cholestan-3α-ol by Lin, Ho-Shen, Rampersaud, Ashraff A, Richett, Michael E, Harper, Richard W, Beavers, Lisa S, McClure, Don B, Gardner, Anthony J, Eacho, Patrick I, Foxworthy, Patricia S, Gadski, Robert A

“…4α-(2-Propenyl)-5α-cholestan-3α-ol (LY295427) was previously identified from a Chinese hamster ovary (CHO) cell-based low density lipoprotein…”
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Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. Part 6: Further focus on the contracted C4'-side chain analogues by TAKEUCHI, K, KOHN, T. J, HARPER, R. W, LIN, H.-S, GIFFORD-MOORE, D. S, RICHETT, M. E, SALL, D. J, SMITH, G. F, MINSHENG ZHANG

“…Novel benzo[b]thiophene diamine thrombin inhibitors were investigated, focusing on a contracted C4'-side chain series. SAR studies identified compounds with…”
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Dibasic benzo[ b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 2: sidechain optimization and demonstration of in vivo efficacy by Zhang, Minsheng, Bailey, Dianna L., Bastian, Jolie A., Briggs, Stephen L., Chirgadze, Nickolay Y., Clawson, David K., Denney, Michael L., Gifford-Moore, Donetta S., Harper, Richard W., Johnson, Lea M., Klimkowski, Valentine J., Kohn, Todd J., Lin, Ho-Shen, McCowan, Jefferson R., Richett, Michael E., Sall, Daniel J., Smith, Amy J., Smith, Gerald F., Snyder, David W., Takeuchi, Kumiko, Utterback, Barbara G., Yan, Sau-Chi B.

“…Potent, subnanomolar thrombin inhibitors 4, 5, and 6 are developed through side chain optimization of novel, benzo[ b]thiophene-based small organic entities 2…”
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Synthesis of 4α-(2-propenyl)-5,6-secocholestan-3α-ol, a Novel B-ring Seco Analog of the Hypocholesterolemic Agent 4α-(2-propenyl)-5α-cholestan-3α-ol by Lin, Ho-Shen, Rampersaud, Ashraff A., Richett, Michael E., Beavers, Lisa S., McClure, Don B., Gadski, Robert A.

“…4α-(2-Propenyl)-5α-cholestan-3α-ol (LY295427) was previously identified from a CHO cell-based assay to be a potent LDL receptor up-regulator and had…”
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