Saliva versus serum estradiol: Implications for research studies using postmenopausal women

Saliva versus serum estradiol: Implications for research studies using postmenopausal women

The authors investigated saliva as a potentially reliable medium for estradiol (E2) measurements in postmenopausal women. The goal of this study was to determine whether or not saliva could be used in studies of postmenopausal women in place of serum samples. Specifically, the authors wondered wheth...

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Bibliographic Details
Published in:Progress in neuro-psychopharmacology & biological psychiatry Vol. 29; no. 5; pp. 727 - 732
Main Authors: Tivis, Laura J., Richardson, Michelle D., Peddi, Erica, Arjmandi, Bahram
Format: Journal Article
Language:English
Published: England Elsevier Inc 01-06-2005
Subjects:
Aged
Alcohol Drinking - blood
Cognition - physiology
Estradiol
Estradiol - blood
Estradiol - metabolism
Estrogen Replacement Therapy
Estrogen therapy
Ethnic Groups
Female
Humans
Middle Aged
Postmenopausal women
Postmenopause - blood
Postmenopause - metabolism
Reference Values
Saliva
Saliva - chemistry
Serum
Social Class
SES
Serum
Postmenopausal women
Estrogen therapy
E2
Estradiol
Saliva
BMI
ET
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Summary:The authors investigated saliva as a potentially reliable medium for estradiol (E2) measurements in postmenopausal women. The goal of this study was to determine whether or not saliva could be used in studies of postmenopausal women in place of serum samples. Specifically, the authors wondered whether or not saliva and serum E2, obtained simultaneously from samples collected from postmenopausal women, would correlate. Samples of saliva and serum were collected simultaneously from 43 postmenopausal women. 31 were regular users of estrogen therapy (ET), 12 used no ET. Pearson's correlation coefficients were conducted to determine the degree of relationship between saliva and serum samples among ET users and non-users. Among ET users saliva and serum E2 levels were significantly and positively correlated ( r = 0.81, p < 0.0001). The two E2 values were not significantly correlated among ET non-users ( r = 0.32, p < 0.31). These data suggest that saliva E2 may be a fairly robust predictor of serum E2, but only among postmenopausal women who use ET.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0278-5846
1878-4216
DOI:10.1016/j.pnpbp.2005.04.029