Search Results - "Richardson, Jennifer H."

Tumor-specific activation of an EGFR-targeting probody enhances therapeutic index by Desnoyers, Luc R, Vasiljeva, Olga, Richardson, Jennifer H, Yang, Annie, Menendez, Elizabeth E M, Liang, Tony W, Wong, Chihunt, Bessette, Paul H, Kamath, Kathy, Moore, Stephen J, Sagert, Jason G, Hostetter, Daniel R, Han, Fei, Gee, Jason, Flandez, Jeanne, Markham, Kate, Nguyen, Margaret, Krimm, Michael, Wong, Kenneth R, Liu, Shouchun, Daugherty, Patrick S, West, James W, Lowman, Henry B

“…Target-mediated toxicity constitutes a major limitation for the development of therapeutic antibodies. To redirect the activity of antibodies recognizing…”
Get more information

Conditional PD-1/PD-L1 Probody Therapeutics Induce Comparable Antitumor Immunity but Reduced Systemic Toxicity Compared with Traditional Anti-PD-1/PD-L1 Agents by Assi, Hikmat H, Wong, Chihunt, Tipton, Kimberly A, Mei, Li, Wong, Ken, Razo, Jennifer, Chan, Chanty, Howng, Bruce, Sagert, Jason, Krimm, Michael, Diep, Linnea, Jang, Andrew, Nguyen, Margaret T, Lapuyade, Nicole, Singson, Victoria, Villanueva, Ruth, Paidhungat, Madan, Liu, Shouchun, Rangan, Vangipuram, Vasiljeva, Olga, West, James W, Richardson, Jennifer H, Irving, Bryan, Daniel, Dylan, Belvin, Marcia, Kavanaugh, W Michael

“…Immune-checkpoint blockade has revolutionized cancer treatment. However, most patients do not respond to single-agent therapy. Combining checkpoint inhibitors…”
Get more information

Abstract 3211: PD-1-targeted Probody therapeutics provide anti-tumor efficacy and a 10-fold dose protection against systemic autoimmunity in preclinical studies by Tipton, Kimberly A., Chan, Chanty, Wong, Kenneth R., Singson, Victoria, Richardson, Jennifer H., Kavanaugh, W Michael, Irving, Bryan A., West, James W.

“…Abstract Immuno-oncology approaches have transformed the treatment of advanced melanoma, NSCLC and an increasing number of other cancers. Antibodies targeting…”
Get full text

Phenotypic Knockout of the High-Affinity Human Interleukin 2 Receptor by Intracellular Single-Chain Antibodies Against the α Subunit of the Receptor by Richardson, Jennifer H., Sodroski, Joseph G., Waldmann, Thomas A., Marasco, Wayne A.

“…The experimental manipulation of peptide growth hormones and their cellular receptors is central to understanding the pathways governing cellular signaling and…”
Get full text

Abstract A164: EGFR-CD3 bispecific Probody™ therapeutic induces tumor regressions and increases maximum tolerated dose >60-fold in preclinical studies by Boustany, Leila M., Wong, Laurie, White, Clayton W., Diep, Linnea, Huang, Yuanhui, Liu, Shouchun, Richardson, Jennifer H., Kavanaugh, W. Michael, Irving, Bryan A.

“…Abstract T cell-engaging bispecific antibodies (TCBs) are highly potent therapeutics that direct the activity of cytotoxic T cells to tumors. TCBs have shown…”
Get full text

Virus inactivation in a proportion of human T-cell leukaemia virus type I-infected T-cell clones arises through naturally occurring mutations by Rose, Nicola J, Richardson, Jennifer H, Desselberger, Ulrich, Lever, Andrew M. L

“…University of Cambridge Department of Medicine, Level 5, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UK 1 Clinical Microbiology and Public Health…”
Get full text

Abstract A203: CD3-EGFR bispecific Probody™ therapeutics induced tumor regressions and increased therapeutic window in preclinical studies by LaPorte, Sherry L., Hostetter, Daniel R., Wong, Laurie, Razo, Jennifer, Diep, Linnea, White, Clayton W., Richardson, Jennifer H., Kavanaugh, W. Michael, Irving, Bryan A.

“…Abstract T cell-engaging bispecific antibodies (TCBs) represent a highly potent modality to direct the activity of cytotoxic T cells to tumors. TCBs are…”
Get full text

Intracellular antibodies: development and therapeutic potential by Richardson, Jennifer H., Marasco, Wayne A.

“…Single-chain antibodies, synthesized by the cell and targeted to a particular cellular compartment, can be used to interfere in a highly specific manner with…”
Get full text

Generation of a Fully Human High Affinity Neutralizing Antibody Against MT-SP1/Matriptase and Its Potential Role for the Treatment of B Cell Lymphoma by Foltz, Ian N., Morkowski, Stan K., Scatena, Caroline D., Ling, Peter, Li, Hao, Liu, Ying, King, Chadwick T., Kang, Jaspal, Manchulenko, Kathy, Perkins, Lisa, Kang, Sukhbir, Chen, Minchao, Godfrey, Wayne, Keyt, Bruce, Richardson, Jennifer H.

“…Membrane-type serine protease 1 (MT-SP1)/Matriptase is a type II transmembrane serine protease that is primarily expressed in epithelial cells and is…”
Get full text

Packaging of human immunodeficiency virus type 1 RNA requires cis-acting sequences outside the 5' leader region by RICHARDSON, J. H, CHILD, L. A, LEVER, A. M. L

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

cis-acting sequences involved in human immunodeficiency virus type 1 RNA packaging by Kaye, J F, Richardson, J H, Lever, A M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Intracellular antibodies against HIV-1 envelope protein for AIDS gene therapy by Marasco, W A, Chen, S, Richardson, J H, Ramstedt, U, Jones, S D

Get more information

T-Cell Activation by Autologous Human T-Cell Leukemia Virus Type I-Infected T-Cell Clones by Wucherpfennig, Kai W., Hollsberg, Per, Richardson, Jennifer H., Benjamin, Deborah, Hafler, David A.

“…A unique feature of both human T-cell leukemia virus type I (HTLV-I) carriers and subjects with HTLV-I-associated myelopathy/tropical spastic paraparesis…”
Get full text

Inducible Knockout of the Interleukin-2 Receptor α Chain: Expression of the High-Affinity IL-2 Receptor Is Not Required for thein VitroGrowth of HTLV-I-Transformed Cell Lines by Richardson, Jennifer H., Waldmann, Thomas A., Sodroski, Joseph G., Marasco, Wayne A.

“…Adult T cell leukemia (ATL) is an aggressive malignancy that is associated with HTLV-I infection and characterized by constitutive expression of the…”
Get full text

Inducible knockout of the interleukin-2 receptor alpha chain: expression of the high-affinity IL-2 receptor is not required for the in vitro growth of HTLV-I-transformed cell lines by Richardson, J H, Waldmann, T A, Sodroski, J G, Marasco, W A

“…Adult T cell leukemia (ATL) is an aggressive malignancy that is associated with HTLV-I infection and characterized by constitutive expression of the…”
Get full text

Helper virus-free transfer of human immunodeficiency virus type 1 vectors by Richardson, Jennifer H, Kaye, Jane F, Child, Lisa A, Lever, Andrew M. L

“…University of Cambridge Department of Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK Recombinant vectors based on the type 1 human…”
Get full text

PCR Analysis of DNA from Multiple Sclerosis Patients for the Presence of HTLV-I by Bangham, Charles R. M., Nightingale, Simon, Cruickshank, J. K., Daenke, Susan

Get full text

PCR Analysis of DNA from Multiple Sclerosis Patients for the Presence of HTLV-I by Charles R. M. Bangham, Nightingale, Simon, Cruickshank, J. K., Daenke, Susan, Richardson, Jennifer H., Wucherpfennig, Kai W., Endo, N., Rudge, Peter, Dalgleish, Angus G., Hafler, David A.

“…A comment and response is presented on a 1985 study of multiple sclerosis patients and the disease's similarity to TPS, also related to infection by HTLV-1…”
Get full text

CaMV gene expression: The analysis of two CaMV promoters in yeast and higher plants by Richardson, Jennifer H

“…The aim of this study was to assess the feasibility of using the budding yeast Saccharomyces cerevisiae as a system in which to analyse plant promoters. The…”
Get full text