Search Results - "Richardson, James A."

Transient Regenerative Potential of the Neonatal Mouse Heart by Porrello, Enzo R, Mahmoud, Ahmed I, Simpson, Emma, Hill, Joseph A, Richardson, James A, Olson, Eric N, Sadek, Hesham A

“…Certain fish and amphibians retain a robust capacity for cardiac regeneration throughout life, but the same is not true of the adult mammalian heart. Whether…”
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Hippo pathway effector Yap promotes cardiac regeneration by Xin, Mei, Kim, Yuri, Sutherland, Lillian B., Murakami, Masao, Qi, Xiaoxia, McAnally, John, Porrello, Enzo R., Mahmoud, Ahmed I., Tan, Wei, Shelton, John M., Richardson, James A., Sadek, Hesham A., Bassel-Duby, Rhonda, Olson, Eric N.

“…The adult mammalian heart has limited potential for regeneration. Thus, after injury, cardiomyocytes are permanently lost, and contractility is diminished. In…”
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Control of Stress-Dependent Cardiac Growth and Gene Expression by a MicroRNA by van Rooij, Eva, Sutherland, Lillian B, Qi, Xiaoxia, Richardson, James A, Hill, Joseph, Olson, Eric N

“…The heart responds to diverse forms of stress by hypertrophic growth accompanied by fibrosis and eventual diminution of contractility, which results from…”
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Modulation of K-Ras-Dependent Lung Tumorigenesis by MicroRNA-21 by Hatley, Mark E., Patrick, David M., Garcia, Matthew R., Richardson, James A., Bassel-Duby, Rhonda, van Rooij, Eva, Olson, Eric N.

“…Lung cancer is the leading cause of cancer-related deaths in the world, and non-small-cell lung cancer (NSCLC) accounts for 80% of cases. MicroRNA-21 ( miR-21)…”
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A Family of microRNAs Encoded by Myosin Genes Governs Myosin Expression and Muscle Performance by van Rooij, Eva, Quiat, Daniel, Johnson, Brett A., Sutherland, Lillian B., Qi, Xiaoxia, Richardson, James A., Kelm, Robert J., Olson, Eric N.

“…Myosin is the primary regulator of muscle strength and contractility. Here we show that three myosin genes, Myh6, Myh7, and Myh7b, encode related intronic…”
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The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis by Wang, Shusheng, Aurora, Arin B., Johnson, Brett A., Qi, Xiaoxia, McAnally, John, Hill, Joseph A., Richardson, James A., Bassel-Duby, Rhonda, Olson, Eric N.

“…Endothelial cells play essential roles in maintenance of vascular integrity, angiogenesis, and wound repair. We show that an endothelial cell-restricted…”
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Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size by Xin, Mei, Kim, Yuri, Sutherland, Lillian B, Qi, Xiaoxia, McAnally, John, Schwartz, Robert J, Richardson, James A, Bassel-Duby, Rhonda, Olson, Eric N

“…The Hippo signaling pathway regulates growth of the heart and other tissues. Hippo pathway kinases influence the activity of various targets, including the…”
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MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury by Xin, Mei, Small, Eric M, Sutherland, Lillian B, Qi, Xiaoxia, McAnally, John, Plato, Craig F, Richardson, James A, Bassel-Duby, Rhonda, Olson, Eric N

“…Vascular injury triggers dedifferentiation and cytoskeletal remodeling of smooth muscle cells (SMCs), culminating in vessel occlusion. Serum response factor…”
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microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart by Liu, Ning, Bezprozvannaya, Svetlana, Williams, Andrew H, Qi, Xiaoxia, Richardson, James A, Bassel-Duby, Rhonda, Olson, Eric N

“…MicroRNAs (miRNAs) modulate gene expression by inhibiting mRNA translation and promoting mRNA degradation, but little is known of their potential roles in…”
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Microbial Dormancy Supports Multi‐Species Coexistence Under Resource Fluctuations by Letten, Andrew D., Yamamichi, Masato, Richardson, James A., Ke, Po‐Ju

“…ABSTRACT The ability for microbes to enter dormant states is adaptive under resource fluctuations and has been linked to the maintenance of diversity…”
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Requirement of MEF2A, C, and D for skeletal muscle regeneration by Liu, Ning, Nelson, Benjamin R., Bezprozvannaya, Svetlana, Shelton, John M., Richardson, James A., Bassel-Duby, Rhonda, Olson, Eric N.

“…Regeneration of adult skeletal muscle following injury occurs through the activation of satellite cells, an injury-sensitive muscle stem cell population that…”
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Histone Deacetylases 1 and 2 Control the Progression of Neural Precursors to Neurons during Brain Development by Montgomery, Rusty L., Hsieh, Jenny, Barbosa, Ana C., Richardson, James A., Olson, Eric N.

“…The molecular mechanism by which neural progenitor cells commit to a specified lineage of the central nervous system remains unknown. We show that HDAC1 and…”
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A Signature Pattern of Stress-Responsive MicroRNAs That Can Evoke Cardiac Hypertrophy and Heart Failure by van Rooij, Eva, Sutherland, Lillian B., Liu, Ning, Williams, Andrew H., McAnally, John, Gerard, Robert D., Richardson, James A., Olson, Eric N.

“…Diverse fors of injury and stress evoke a hypertrophic growth response in adult cardiac myocytes, which is characterized by an increase in cell size, enhanced…”
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Cardiac autophagy is a maladaptive response to hemodynamic stress by Zhu, Hongxin, Tannous, Paul, Johnstone, Janet L, Kong, Yongli, Shelton, John M, Richardson, James A, Le, Vien, Levine, Beth, Rothermel, Beverly A, Hill, Joseph A

“…Cardiac hypertrophy is a major predictor of heart failure and a prevalent disorder with high mortality. Little is known, however, regarding mechanisms…”
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Myocardin-Related Transcription Factor-A Controls Myofibroblast Activation and Fibrosis in Response to Myocardial Infarction by Small, Eric M, Thatcher, Jeffrey E, Sutherland, Lillian B, Kinoshita, Hideyuki, Gerard, Robert D, Richardson, James A, DiMaio, J. Michael, Sadek, Hesham, Kuwahara, Koichiro, Olson, Eric N

“…RATIONALE:Myocardial infarction (MI) results in loss of cardiac myocytes in the ischemic zone of the heart, followed by fibrosis and scar formation, which…”
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Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility by Montgomery, Rusty L, Davis, Christopher A, Potthoff, Matthew J, Haberland, Michael, Fielitz, Jens, Qi, Xiaoxia, Hill, Joseph A, Richardson, James A, Olson, Eric N

“…Histone deacetylases (HDACs) tighten chromatin structure and repress gene expression through the removal of acetyl groups from histone tails. The class I…”
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Regulation of PI3-kinase/Akt signaling by muscle-enriched microRNA-486 by Small, Eric M, O'Rourke, Jason R, Moresi, Viviana, Sutherland, Lillian B, McAnally, John, Gerard, Robert D, Richardson, James A, Olson, Eric N

“…microRNAs (miRNAs) play key roles in modulating a variety of cellular processes through repression of mRNA targets. In a screen for miRNAs regulated by…”
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Myogenin and Class II HDACs Control Neurogenic Muscle Atrophy by Inducing E3 Ubiquitin Ligases by Moresi, Viviana, Williams, Andrew H., Meadows, Eric, Flynn, Jesse M., Potthoff, Matthew J., McAnally, John, Shelton, John M., Backs, Johannes, Klein, William H., Richardson, James A., Bassel-Duby, Rhonda, Olson, Eric N.

“…Maintenance of skeletal muscle structure and function requires innervation by motor neurons, such that denervation causes muscle atrophy. We show that…”
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Histone Deacetylase 7 Maintains Vascular Integrity by Repressing Matrix Metalloproteinase 10 by Chang, Shurong, Young, Bryan D., Li, Shijie, Qi, Xiaoxia, Richardson, James A., Olson, Eric N.

“…Development and homeostasis of the cardiovascular system require intimate interactions between endothelial and smooth muscle cells, which form a seamless…”
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The G protein-coupled receptor Gpr161 regulates forelimb formation, limb patterning and skeletal morphogenesis in a primary cilium-dependent manner by Hwang, Sun-Hee, White, Kevin A, Somatilaka, Bandarigoda N, Shelton, John M, Richardson, James A, Mukhopadhyay, Saikat

“…The role of basal suppression of the sonic hedgehog (Shh) pathway and its interaction with Indian hedgehog (Ihh) signaling during limb/skeletal morphogenesis…”
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